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Sara Lindgren

Research Scientist

Nordic Genomics Consortium, Sweden

Sara applies population-scale sequencing to map rare variant contributions to cardiometabolic disease.

GenomicsMedicine
ORCID
0000-0000-0000-0007
Publications
2

Publications

Original ResearchMolecular Medicine & Therapeutics

Metabolic reprogramming reverses T-cell exhaustion in solid tumour microenvironments

Mei Chen, Sara Lindgren

Exhausted CD8+ T cells limit the efficacy of checkpoint blockade in many solid tumours. Using single-cell transcriptomics and metabolic flux analysis, we identify a mitochondrial bottleneck that marks terminally exhausted populations. Pharmacological restoration of fatty-acid oxidation rescued effector function ex vivo and improved tumour control in combination with anti-PD-1 therapy in murine models.

Original ResearchMolecular Medicine & Therapeutics

Population-scale sequencing reveals rare-variant burden in early-onset cardiometabolic disease

Sara Lindgren, Mei Chen

Rare coding variants contribute to cardiometabolic risk, but their aggregate burden is difficult to quantify. Whole-exome sequencing of 180,000 participants identified 14 genes with significant rare-variant associations, five of which are novel. Carriers of high-impact variants showed onset of disease on average nine years earlier than non-carriers.