Applied Artificial Intelligence Letters
Rapid communication of methods and applications in machine learning, with emphasis on reproducibility, evaluation standards and responsible deployment in science.
- Editor-in-Chief
- Dr. Priya Raman
- ISSN
- 3051-1004

Journals
Field-leading, community-edited journals spanning the natural, life, health and computational sciences.
Rapid communication of methods and applications in machine learning, with emphasis on reproducibility, evaluation standards and responsible deployment in science.
Theoretical and data-driven approaches to understanding neural computation, including network modelling, neuroimaging analytics and brain-inspired learning systems.
Interdisciplinary research on the physical, chemical and biological processes governing the Earth system, from atmospheric dynamics to cryosphere change and land–ocean interactions.
Translational studies linking molecular mechanisms to clinical outcomes, spanning genomics, immunology, drug discovery and precision therapeutics.
Just published
Recently published peer-reviewed research from across the Frontiersin journal portfolio.
Elena Varga, Rafael Moreno
Arctic sea ice has thinned substantially over the past three decades, yet the relative contributions of individual feedback processes remain debated. We combine a 30-year record of satellite altimetry with an ensemble of coupled model simulations to partition thinning into albedo, cloud and ocean heat transport contributions. Our results indicate that ocean heat convergence explains a larger share of winter thinning than previously estimated, while surface albedo feedback dominates summer losses. These findings refine projections of seasonally ice-free conditions and highlight observational gaps in the Atlantic sector.
Daniel Osei, Lucas Ferreira
Persistent activity has long been proposed as the substrate of working memory, but sustaining it in sparse cortical networks is energetically costly. We show that short-term synaptic facilitation allows information to be held in latent synaptic states, reducing the need for continuous firing. Simulations reproduce the activity-silent dynamics observed in primate prefrontal recordings and predict a characteristic reactivation signature after brief non-specific input.
Mei Chen, Sara Lindgren
Exhausted CD8+ T cells limit the efficacy of checkpoint blockade in many solid tumours. Using single-cell transcriptomics and metabolic flux analysis, we identify a mitochondrial bottleneck that marks terminally exhausted populations. Pharmacological restoration of fatty-acid oxidation rescued effector function ex vivo and improved tumour control in combination with anti-PD-1 therapy in murine models.
Lucas Ferreira
Machine-learning surrogates are increasingly used to accelerate expensive physical simulations, but their predictive uncertainty is frequently miscalibrated. We introduce a conformal ensemble procedure that provides finite-sample coverage guarantees without retraining the base model. Across five benchmark simulation tasks, the method achieves nominal coverage with intervals up to 35% narrower than existing baselines.
Aisha Rahman
Compound marine heatwaves are becoming more frequent, yet long-term recovery dynamics of reefs exposed to repeated events are poorly documented. We report eight years of benthic surveys from 24 reef sites and find that recovery depends strongly on structural complexity and herbivore biomass. Sites with intact grazer communities regained 70% of pre-disturbance coral cover within five years.
Jonas Weber
Sulfide solid electrolytes offer high ionic conductivity but suffer from interfacial degradation against lithium metal. We report an atomic-layer-deposited oxyhalide interlayer that suppresses dendrite nucleation and reduces interfacial resistance by an order of magnitude. Symmetric cells cycled stably for over 2,000 hours at practical current densities.
Collaborative collections
Curated collections led by expert guest editors, bringing together diverse perspectives on emerging scientific questions.

Life Sciences & Computing
Bridging neuroscience and computer engineering through spiking networks, neuromorphic hardware and biologically plausible learning rules.
Engineering & Technology
Materials discovery and device engineering for safer, cheaper and longer-lasting batteries and supercapacitors.
Earth & Environment
How marine ecosystems respond to and recover from overlapping pressures including warming, acidification and overfishing.
Community
Professor of Marine Biology
Coastal Research Station, University of the Gulf, Oman
Senior Research Fellow
Accra Centre for Brain Sciences, Ghana
Governance
Editor-in-Chief · Applied Artificial Intelligence Letters
Centre for Responsible Computing
Editor-in-Chief · Advanced Materials & Energy
Danish Laboratory for Sustainable Materials
Editor-in-Chief · Computational Neuroscience Review
Institute of Neural Computation
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