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Molecular Medicine & Therapeutics

Translational studies linking molecular mechanisms to clinical outcomes, spanning genomics, immunology, drug discovery and precision therapeutics.

MedicineGenomicsImmunology
ISSN
3051-1003
Editor-in-Chief
Prof. Amara Lindqvist
Established
2018
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Published research

Latest articles

Original Research

Metabolic reprogramming reverses T-cell exhaustion in solid tumour microenvironments

Mei Chen, Sara Lindgren

Exhausted CD8+ T cells limit the efficacy of checkpoint blockade in many solid tumours. Using single-cell transcriptomics and metabolic flux analysis, we identify a mitochondrial bottleneck that marks terminally exhausted populations. Pharmacological restoration of fatty-acid oxidation rescued effector function ex vivo and improved tumour control in combination with anti-PD-1 therapy in murine models.

Original Research

Population-scale sequencing reveals rare-variant burden in early-onset cardiometabolic disease

Sara Lindgren, Mei Chen

Rare coding variants contribute to cardiometabolic risk, but their aggregate burden is difficult to quantify. Whole-exome sequencing of 180,000 participants identified 14 genes with significant rare-variant associations, five of which are novel. Carriers of high-impact variants showed onset of disease on average nine years earlier than non-carriers.