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Dr. Claire Dubois

Associate Editor

Institut de Recherche Biomédicale

Claire investigates host–pathogen interactions in chronic viral infection.

VirologyHost–pathogen biology
Reviewer
Active reviewer

Recently published in their journal

Original Research

Metabolic reprogramming reverses T-cell exhaustion in solid tumour microenvironments

Mei Chen, Sara Lindgren

Exhausted CD8+ T cells limit the efficacy of checkpoint blockade in many solid tumours. Using single-cell transcriptomics and metabolic flux analysis, we identify a mitochondrial bottleneck that marks terminally exhausted populations. Pharmacological restoration of fatty-acid oxidation rescued effector function ex vivo and improved tumour control in combination with anti-PD-1 therapy in murine models.

Original Research

Population-scale sequencing reveals rare-variant burden in early-onset cardiometabolic disease

Sara Lindgren, Mei Chen

Rare coding variants contribute to cardiometabolic risk, but their aggregate burden is difficult to quantify. Whole-exome sequencing of 180,000 participants identified 14 genes with significant rare-variant associations, five of which are novel. Carriers of high-impact variants showed onset of disease on average nine years earlier than non-carriers.