Review
Published
Application of large language models in early screening of Alzheimer’s disease: a scoping review
Jianan Tian · Weidong Huang · Yongmei Wen · Yifan Liang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1906641
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 97 articles
Case Report
Published
Case Report: Longitudinal evaluation of cerebrospinal fluid Alzheimer’s disease core biomarkers in a case of refractory late-onset epilepsy of unknown etiology
Takafumi Wada · Akira Kuzuya · Kazuma Koda · Sakiho Ueda · Atsushi Shima · Nobukatsu Sawamoto · Akio Ikeda · Ryosuke Takahashi · Riki Matsumoto
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1807027
Original Research
Published
Sex differences in sleep and memory relationships in older adults at risk for Alzheimer’s disease
Negin Sattari · Abhishek Dave · Ivy Y. Chen · Kitty K. Lui · Miranda G. Chappel-Farley · Destiny E. Berisha · Kate E. Sprecher · Brady A. Riedner · Stephanie Jones · Barbara B. Bendlin · Bryce A. Mander · Ruth M. Benca
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1930177
Hypothesis and Theory
Published
A SynNotch-PiggyBac gene circuit for inflammation-responsive IL-10 delivery in Alzheimer’s disease: a hypothesis and design framework
Suhani Gupta · Ronav Gupta
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1866161
Mini Review
Published
Molecular mechanisms underpinning cognitive reserve and resilience
Amber Chen · Sreenithi Bhuvaneshwaran · Yash Akkara · Thomas Burke · Robert Perneczky · Magdalena Sastre
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1957901
Original Research
Published
TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology
Zheng Liu · Yuchen Yu · Yu Wang · Shuohan Ning · Tongshuai Huang · Jingqi Li · Sihan Fan · Chaolong Lu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1920487
Review
Published
Neuromodulatory interventions for Alzheimer’s disease
Ruofan Wang · Botao Zhu · Qingda Guo · Jun Steed Huang · Wandong Zhang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1925914
Original Research
Published
Influenza A (H1N1)pdm infection exacerbates behavioral, cognitive, and synaptic impairments in 5xFAD mice
Anastasiya Rakovskaya · Alexey Lozhkov · Valeria Tverdokhlebova · Yana Zabrodskaya · Egor Vinokurov · Valeria Kirenskaya · Alexander Erofeev · Angelika Garshinina · Valeria Zryacheva · Anna Shtro · Ekaterina Pchitskaya · Olga Vlasova · Ekaterina Elpaeva · Pavel Dav · Ilya Bezprozvanny · Andrey Vasin
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1955816
Review
Published
Noninvasive diagnosis of Alzheimer’s disease: a review of emerging biomarkers and multimodal approaches
Junsheng Zhao · Chenqi Nie · Rong Gao · Zekai Hu · Yajie Lin
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1964029
Review
Published
Advances in artificial intelligence-driven MRI research in Alzheimer’s disease
Lihua Deng · Yan Zeng · Peiling Ou · Suyi Zhou · Yu Gou · Cong Huang
Frontiers in Neurology
doi 10.3389/fneur.2026.1943265
Review
Published
GLP-1 receptor agonists as potential disease-modifying agents in Parkinson’s and Alzheimer’s disease: mechanisms, clinical trial evidence, and the neuroprotection horizon
Mohamed Alsharif · Omran Shrebaty · Mohammad Ammar Aloudah · Mayar Alqahtani · Raghad Saud Aloubili · Marafi Jammaa Ahmed · Bana Albani · Ahmad El Bana
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1969490
Systematic Review
Published
Gait characteristics in people with central nervous system disorders under dual-task experimental paradigms: a scoping review
Haizhe Jin · Jiahao Zhang · Xinyi Meng · Jianing Li · Su Meng · Quanwei Fu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1807030
Review
Published
Pyroptosis: a potential target and research progress of exercise in ameliorating Alzheimer’s disease pathology
Shao Jie · Zhu Lei
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1983962
Original Research
Published
Chronic post-traumatic stress disorder-related behavioral traits develop in female rats exposed to repetitive low-level blast injury and are reversible with (2R,6R)-hydroxynorketamine
Georgina Perez Garcia · Gissel M. Perez · Rita De Gasperi · Miguel A. Gama Sosa · Carolyn W. Zhu · Serena Yeung · Shahrukh Khalique · Carlos A. Toro · Patrick R. Hof · Gregory A. Elder
Frontiers in Neurology
doi 10.3389/fneur.2026.1830745
Original Research
Published
Regional tau burden tracks with lower microglial HLA class II transcription in the human brain
Fan Li · Suqin Jin · Ping Wang · Hui Yang · Xianghua Zhuang · Feifei Feng · Peng Cheng
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1979981
Original Research
Published
Reduced serum LEFTY2 and disease-dependent biomarker associations in Alzheimer’s disease: an exploratory study
Wei Wuli · Raymond Y. Lo · Horng-Jyh Harn · Tzyy-Wen Chiou · Yue-Xuan Xu · Yuncin Luo · Ivan Wijaya · Shinn-Zong Lin
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1955495
Original Research
Published
Association of statin use with reduced risk of Alzheimer’s disease: findings in UK Biobank
Hui Yang · Can Zhu · Jialu He · Yan Wei · Dongmei Li · Xuan Luo · Ying Wang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1961033
Original Research
Published
Transcriptomic analysis identifies candidate molecular mechanisms underlying SCF+G-CSF-reduced neuropathology in aged APP/PS1 mice
Afua Addo · Bin Li · Sasidhar Murikinati · Robert Gardner · Li-Ru Zhao
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1705436
Review
Published
Epigenetics in Alzheimer’s disease: from molecular mechanisms to emerging novel biomarkers
Elisabetta D’Aversa · Miriana Grisafi · Salvatore Pernagallo · Francesca Salvatori · Ajay V. Singh · Alessia Nucciarone · Veronica Tisato · Donato Gemmati
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1959361
Original Research
Published
Atherosclerotic cardiovascular disease risk is associated with AT(N)V neuroimaging biomarkers and cognitive impairment in the health and aging brain study–health disparities cohort
Kimberly Espejo · Ryan Rulkens · Cellas A. Hayes · Joey A. Contreras
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1874472
Review
Published
Ethical challenges in the clinical translation of anti-amyloid monoclonal antibodies for Alzheimer’s disease: a scoping review
Alexandra Wicker · Amanda Courtright-Lim · Jon Tilburt
Frontiers in Psychiatry
doi 10.3389/fpsyt.2026.1953954
Review
Published
Dexmedetomidine as a potential neuroprotective agent against Alzheimer’s disease: molecular mechanisms and therapeutic perspectives
Jun Kang · Yongbo Duan · Jiaxuan Bi · Jiangping Liu · Wenjun Yan
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1952923
Perspective
Published
Hydrogen gas and olfactory dysfunction in Alzheimer’s disease: the Hydrogen–Olfactory–Limbic hypothesis
Ligao Bao · Dunfu Eer
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1937419
Original Research
Published
Safety of lecanemab in real-world patients with Alzheimer’s disease: a prospective, observational case series supported by FAERS signal analysis
Haixia Ji · Yang Yang · Xingqi Wu · Erhao Bao
Frontiers in Neuroinformatics
doi 10.3389/fninf.2026.1977226
Original Research
Published
Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch
Carlye Frisch · Lauren Baker · Gayathri Srinivasan · Albert E. Mintah · Salma Leyasi · Morgan Pedroza · Brooke Galyon · David A. Brafman
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1856154
Original Research
Published
No evidence that serum metabolite slopes improve held-out prediction of clinical progression in the Alzheimer’s disease neuroimaging initiative
Tia Warrick · Manali Misra · Stephen Kataria · Jahnavi Patel · Bhuvi Ajmera
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1942662
Brief Research Report
Published
Cardiorespiratory fitness is associated with cerebral oxygen extraction in Alzheimer’s disease
Paul J. Kueck · Zachary D. Green · Raechel Camones · Casey S. John · Robyn A. Honea · Jeffrey M. Burns · Eric D. Vidoni · Jill K. Morris
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1943472
Original Research
Published
Network-level restoration of impaired memory function in early Alzheimer’s disease via GluN2B modulation: insights from a hippocampal CA1–CA3 model
Fabio Librizzi · Saana Seppälä · Marja-Leena Linne · Michele Migliore · Ausra Saudargiene
Frontiers in Computational Neuroscience
doi 10.3389/fncom.2026.1953352
Mini Review
Published
The gut-brain axis in Alzheimer’s and Parkinson’s diseases: a comparative perspective
Riddhi Upadhyay · Chandhini C. · Susmita Kar · Sajith Sathyamoorthy · Xavier Pitchaimuthu · Murugan Sevanan
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1942228
Mini Review
Published
Evolution of deep learning for structural magnetic resonance imaging analysis in Alzheimer’s disease: from slice-level classification to brain structure modeling
Yunchen Chen · Tingshan Liu · Guanxun Cheng
Frontiers in Human Neuroscience
doi 10.3389/fnhum.2026.1958462
Perspective
Published
Neuroimmune phenotypes in brain aneurysms and neurodegenerative diseases
Francis J. Lauzier · David C. Lauzier
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1916561
Original Research
Published
Muscle quality index combined with plasma metabolomics: enhancing risk stratification for post-stroke dementia
Zhen Tan · Shuang Li · Tianjiao Li · Lei Liu · Xinrui Xue · Xiaoping Li · Hongqiang Ren
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1837030
Review
Published
New insight into Alzheimer’s disease: small molecule-Aβ in the brain transport and peripheral organ clearance
Tianci Ma · Yongyi Li · Yuting Ding · Shijie Liu · Chuanhao Gao · Xiang Li · Zhiqian Tong · Yan Lv
Frontiers in Aging
doi 10.3389/fragi.2026.1921485
Original Research
Published
A pilot study of invasive vagus nerve stimulation in Chinese patients with Alzheimer’s disease: preliminary results on safety, cognition, and biomarkers
Yingchuan Chen · Tenghong Lian · Dongmei Luo · Rujin Wang · Aolan Li · Dongmei Gao · Tingting Du · Qin Xu · Anxin Wang · Fangang Meng · Anchao Yang · Wei Zhang · Jianguo Zhang
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1934496
Original Research
Published
Alzheimer’s disease diagnosis based on gene selection and cross-tissue validation
Xiaolan Zhang · Xiaotong Tang · Qian Bo · Yu Ma · Fang Shi · Hongpeng Hou
Frontiers in Genetics
doi 10.3389/fgene.2026.1890236
Review
Published
Multipath interaction network of annexin A2: multifaceted regulation and translational perspectives in neurological diseases
Yong Guan · Ping Gu · Dachuang Guo · Liqiang Huang · Dongye Lian · Caicai Zhang · Jigao Feng · Hao Peng
Frontiers in Genetics
doi 10.3389/fgene.2026.1916220
Original Research
Published
Virtual screening of phytochemicals against multiple protein targets of Alzheimer’s disease
Samuel Mesfin · Naamah Bloch · Abraham O. Samson
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1922953
Original Research
Published
Neuro-psycho MMSig: multimodal mechanism enrichment platform for neuropsychiatric disorders
Vinay Srinivas Bharadhwaj · Karim S. Shalaby · Sathvik Guru Rao · Bruce Schultz · Jiayuan Zhang · Daniel Domingo-Fernández · Martin Hofmann-Apitius · Alpha Tom Kodamullil
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1898607
Original Research
Published
A home-finding task in virtual reality to test entorhinal path integration performance in patients with mild cognitive impairment
Sarah Philippen · Frederik Folkerts · Annika Hanert · Yasmin Fiedler · Kim Lampe · Julius Rave · Younes Adam Tabi · Robby Schönfeld · Oliver Granert · Felix Woelk · Thorsten Bartsch
Frontiers in Virtual Reality
doi 10.3389/frvir.2026.1745650
Original Research
Published
Efficacy of anticoagulation therapy in elderly patients with clinically diagnosed Alzheimer’s disease and atrial fibrillation: a clinical outcomes study
Xinhui Wang · Xinying Yang · Yiman Huang · Peng Qian · Hongyan Duan
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1874032
Review
Published
Lysosomes as chemical and metabolic organizers of central nervous system injury and repair
Tengfei Zhao · Hanxu Huang · Yifan Wang · Yuliang Zhong · Zhiwei Zhong · Deting Xue · Wei Zhu · Kan Xu
Frontiers in Chemistry
doi 10.3389/fchem.2026.1891677
Systematic Review
Published
Usability evaluation of virtual reality-based cognitive intervention for older people: a systematic review
Tek-Yong Lim · Zhiqiang Luo
Frontiers in Computer Science
doi 10.3389/fcomp.2026.1834304
Review
Published
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
Toshiki Otoda · Hideto Nakajima · Tadateru Takayama
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1892506
Original Research
Published
Explanatory limitations of CSF, plasma, and MRI biomarkers for inflammation and blood–brain barrier disruption in dementia
Azadeh Golduzian · Erik B. Erhardt · Arvind Caprihan · John C. Adair · Janice E. Knoefel · Jill Prestopnik · Sasha Hobson · Sephira Ryman · Andrei Vakhtin · Kiran Bhaskar · Gary A. Rosenberg
Frontiers in Aging
doi 10.3389/fragi.2026.1923046
Original Research
Published
Cognitive-behavioral phenotypes in FMR1 premutation carriers: a cross-population comparison with mild cognitive impairment
Nell Maltman · Jessica Greenlee · Kimberly D. Mueller · Barbara B. Fransway · James T. Shira · Davina Hammann · Sumi Lee · Hyeri Lee · Ali Naderi Malek
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1943587
Original Research
Published
Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum
Andrea Angarita-Rodríguez · Johan H. Largo-González · Julián Pérez-Mejía · Daniel Balcazar · Viviana Vargas-López · Jason A. Papin · Andrés Pinzón · Janneth González
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1897648
Review
Published
Activation of silent synapses driven by emerging technologies: mechanisms, disease associations, and prospects for clinical translation
Yongli Li · Yong Liao · Shouyao Zhang · Chenggui Xu · Ruhua Lan · Pengbin Zhao · Ruilu Liu · Yongli Song · Xinghe Zhang
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1923815
Original Research
Published
Polygenic score for sleep duration in relation to the risk of Alzheimer’s disease: results from the UK biobank
Angel T. Y. Wong · Sarah Floud · Gillian K. Reeves · Michael V. Holmes · Ruth C. Travis · Cornelia M. van Duijn · Aiden Doherty · Karl Smith-Byrne
Frontiers in Dementia
doi 10.3389/frdem.2026.1843867