Review
Published
Application of large language models in early screening of Alzheimer’s disease: a scoping review
Jianan Tian · Weidong Huang · Yongmei Wen · Yifan Liang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1906641
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Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 80 articles
Original Research
Published
A clustering approach based on neuropsychological testing to detect early signs of probable MCI among community-dwelling older adults
Rafael Mauti · Chiraz Chouk · Aymeric Guillot · Arnaud Peronin · Patrick Fargier · Pascal Chabaud
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1926431
Original Research
Published
Camk2d upregulation is associated with postoperative cognitive dysfunction in aged rats: pharmacological inhibition of CaMKII attenuates hippocampal neuroinflammation and neuronal apoptosis
Kaihua Wei · Shiwen Fan · Yujia Zhao · Xiaobin Cai · Xinlei Qin · Jingwen Zhai · Liping Xie
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1975677
Editorial
Published
Editorial: Advances in early detection, pathophysiology, and management of mild cognitive impairment
Edgar Vásquez-Carrasco · Cristian Sandoval-Vásquez · Pablo Valdés-Badilla
Frontiers in Medicine
doi 10.3389/fmed.2026.2007251
Original Research
Published
Depression, anxiety, and cognitive function in patients with ischemic cerebrovascular disease: a cross-sectional study based on the Montreal Cognitive Assessment
Weiwen Chen · Yinan Zhuo
Frontiers in Neurology
doi 10.3389/fneur.2026.1854573
Editorial
Published
Editorial: Imaging biomarkers in neurodegenerative diseases: advances and challenges
Francesco Lanfranchi · Andrew R. Bender · Lucas Caldi Gomes
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.2009935
Original Research
Published
TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology
Zheng Liu · Yuchen Yu · Yu Wang · Shuohan Ning · Tongshuai Huang · Jingqi Li · Sihan Fan · Chaolong Lu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1920487
Mini Review
Published
Pain, cognition, and culture in dementia research: a critical synthesis of empirical and methodological literature
Rimsha Taqdees · Tom Mercer · Abigail Olubola Taiwo
Frontiers in Pain Research
doi 10.3389/fpain.2026.1797629
Original Research
Published
A machine learning model for predicting cognitive improvement after scalp cluster needling therapy in patients with post-stroke mild cognitive impairment
Yican Hao · Xia Wei · Pingli Zhao · Hewei Qin
Frontiers in Neurology
doi 10.3389/fneur.2026.1884682
Original Research
Published
Polysomnographic and nocturnal heart rate correlates of cognitive impairment in Parkinson’s disease: a cross-sectional study
Zhang Linwei · Lv Pu · Wang Lu · Zhang Xiangfei · Wang Kang · Jin Miao
Frontiers in Neurology
doi 10.3389/fneur.2026.1913495
Review
Published
Screen exposure and cognitive outcomes in school-aged children and adolescents: a narrative review through the lens of Cognitive Load Theory
Hiya Al Kalbani · Erin Kitt-Lewis
Frontiers in Developmental Psychology
doi 10.3389/fdpys.2026.1958088
Review
Published
Neuromodulatory interventions for Alzheimer’s disease
Ruofan Wang · Botao Zhu · Qingda Guo · Jun Steed Huang · Wandong Zhang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1925914
Original Research
Published
Immediate anxiety-reducing effects of multisensory virtual reality reminiscence therapy in older adults with a wide range of cognitive functions: a pilot study using electrophysiological measures
Keita Ueno · Kazuyuki Niki · Hiroyuki Tanaka · Takeshi Okuda · Daisuke Iwai · Kosuke Sato · Yasuo Naito · Toshinori Ito · Ryouhei Ishii
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1958403
Original Research
Published
Influenza A (H1N1)pdm infection exacerbates behavioral, cognitive, and synaptic impairments in 5xFAD mice
Anastasiya Rakovskaya · Alexey Lozhkov · Valeria Tverdokhlebova · Yana Zabrodskaya · Egor Vinokurov · Valeria Kirenskaya · Alexander Erofeev · Angelika Garshinina · Valeria Zryacheva · Anna Shtro · Ekaterina Pchitskaya · Olga Vlasova · Ekaterina Elpaeva · Pavel Dav · Ilya Bezprozvanny · Andrey Vasin
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1955816
Original Research
Published
Integrated transcriptomic and proteomic profiling reveals C3-associated hippocampal neuroimmune remodeling in sodium bicarbonate-treated sepsis-associated encephalopathy
Housheng Deng · Hua Ling · Lie Liu · Qiuli He · Hao Wang · Zhiming Zhang
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1954272
Original Research
Published
Atherosclerotic cardiovascular disease risk is associated with AT(N)V neuroimaging biomarkers and cognitive impairment in the health and aging brain study–health disparities cohort
Kimberly Espejo · Ryan Rulkens · Cellas A. Hayes · Joey A. Contreras
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1874472
Systematic Review
Published
Comparative efficacy of non-pharmacological interventions for amnestic mild cognitive impairment: a network meta-analysis
Baofang Zhang · Xuanling Li · Qian Zhao · Shuqun Zhang · Yuquan Bai · Youlin Duan · Caien Yu · Chenlin Sui · Aochen Yang · Lianwei Xu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1878590
Perspective
Published
Hydrogen gas and olfactory dysfunction in Alzheimer’s disease: the Hydrogen–Olfactory–Limbic hypothesis
Ligao Bao · Dunfu Eer
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1937419
Original Research
Published
Longitudinal changes in hand dominance and manual dexterity in normal aging and mild cognitive impairment (MCI): a kinematic study
Olena Vasylenko · Claudia Rodríguez-Aranda
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1921208
Original Research
Published
No evidence that serum metabolite slopes improve held-out prediction of clinical progression in the Alzheimer’s disease neuroimaging initiative
Tia Warrick · Manali Misra · Stephen Kataria · Jahnavi Patel · Bhuvi Ajmera
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1942662
Original Research
Published
Complement C4b and factor B in astrocyte-derived exosomes as novel biomarkers for amnestic mild cognitive impairment
Yu Li · Menglu Zhang · Chao Ying · Chao Han · Qimeng Li · Yanning Cai
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1727449
Original Research
Published
Prediction of cognitive impairment in Parkinson’s disease using TabPFN: an integrative analysis of clinical data, longitudinal trajectories, and lipidomics
Zikai Zhou · Jie Liu · Lijuan Wang · Hong Lv · Wencan Jiang · Ling Huang · Guojun Zhang · Ruimin Ma
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1905374
Original Research
Published
Selective autophagy inhibition alleviates oxidative stress-associated neurodegeneration in an AD+CCH model
Xiaorui Huang · Jufang Chen · Zhicheng Lu · Jie Wang · Xuelian Luo · Qiuyan Qin · Qin Yang · Chongdong Jian · Xuebin Li · Jingwei Shang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1870441
Case Report
Published
Case Report: Value of MR relaxometry and spectroscopy in multimodal imaging characterization of limbic encephalitis in systemic sclerosis
Florian Awin Stolz · Andrei Manzhurtsev · Marlene Bönstrup · Daniel Groener · Nico Melzer · Felix Rosenow · Elke Hattingen · Christophe Théo Arendt
Frontiers in Radiology
doi 10.3389/fradi.2026.1945816
Mini Review
Published
Evolution of deep learning for structural magnetic resonance imaging analysis in Alzheimer’s disease: from slice-level classification to brain structure modeling
Yunchen Chen · Tingshan Liu · Guanxun Cheng
Frontiers in Human Neuroscience
doi 10.3389/fnhum.2026.1958462
Review
Published
Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review
Dina Iskakova · Burcu Yener · Altyngul Kamzanova · Aygul Sitakanova · Rifat Hamoudi · Almira Kustubayeva
Frontiers in Integrative Neuroscience
doi 10.3389/fnint.2026.1904444
Review
Published
Explainable artificial intelligence (XAI) in schizophrenia: enhancing transparency in clinical decision-making
Kshitij Srivastava · Ruby Srivastava
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1898853
Systematic Review
Published
Effects of exercise on cognitive function in older adults: a systematic review and meta-analysis of the mediating role of sleep
Wenhui Zheng · Mian Wu · Yuhe Chen · Shaolan Li · Liying Huang
Frontiers in Human Neuroscience
doi 10.3389/fnhum.2026.1949679
Review
Published
Hyperbaric oxygen therapy in sepsis-associated encephalopathy: pathophysiological rationale, preclinical evidence, and translational challenges
Yikun Xie · Yihao Li · Yujing Li · Shuai Chen · Guanqi Song · Hongyu Wang
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1941147
Original Research
Published
A home-finding task in virtual reality to test entorhinal path integration performance in patients with mild cognitive impairment
Sarah Philippen · Frederik Folkerts · Annika Hanert · Yasmin Fiedler · Kim Lampe · Julius Rave · Younes Adam Tabi · Robby Schönfeld · Oliver Granert · Felix Woelk · Thorsten Bartsch
Frontiers in Virtual Reality
doi 10.3389/frvir.2026.1745650
Original Research
Published
Efficacy of anticoagulation therapy in elderly patients with clinically diagnosed Alzheimer’s disease and atrial fibrillation: a clinical outcomes study
Xinhui Wang · Xinying Yang · Yiman Huang · Peng Qian · Hongyan Duan
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1874032
Systematic Review
Published
Usability evaluation of virtual reality-based cognitive intervention for older people: a systematic review
Tek-Yong Lim · Zhiqiang Luo
Frontiers in Computer Science
doi 10.3389/fcomp.2026.1834304
Original Research
Published
Speech and language pathologists' diagnostic approaches to developmental language disorders in German-speaking children with intellectual disability
Jenny Thillmann · Tina Ghaemi · Anna-Lena Scherger
Frontiers in Rehabilitation Sciences
doi 10.3389/fresc.2026.1925293
Correction
Published
Correction: Cognitive and behavioral benefits of newspaper reading in community‐dwelling older adults: a feasibility randomized controlled trial
Mamoru Sato · Sawako Negoto · Shinya Nakano · Chihoko Urata · Tetsuya Ioji · Hideya Kodama · Emi Yoshimura · Yukinori Tasaki · Shinichiro Goroku · Kiichiro Morita · Yoshihisa Shoji
Frontiers in Aging
doi 10.3389/fragi.2026.1992402
Review
Published
Artificial intelligence for sleep-disordered breathing: a taxonomy of methods, data modalities, and clinical applications
Tai Dinh · Daniil Lisik · Philippe Fournier-Viger · Dat Tran · Philip S. Yu · Huynh Van Hong · Ding Zou
Frontiers in Sleep
doi 10.3389/frsle.2026.1927453
Brief Research Report
Published
Mobile dentistry and digital dentures in aged care placements: dental students’ experiences and perceptions
Archana Pradhan · Zakia Sultana Happy · Rahena Akhter · Arash Rudman · Shilpi Ajwani
Frontiers in Oral Health
doi 10.3389/froh.2026.1923430
Original Research
Published
Association between presbycusis and cognitive function: contributing factors in older adult
Duo Wei · Yuehong Chen · Bin Liu · Zhiqiang Tan
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1820873
Systematic Review
Published
The importance of power in photobiomodulation: a systematic review and meta-analysis of high-intensity laser therapy
William Todd Penberthy · Charles E. Vorwaller
Frontiers in Integrative Neuroscience
doi 10.3389/fnint.2026.1914223
Original Research
Published
Explanatory limitations of CSF, plasma, and MRI biomarkers for inflammation and blood–brain barrier disruption in dementia
Azadeh Golduzian · Erik B. Erhardt · Arvind Caprihan · John C. Adair · Janice E. Knoefel · Jill Prestopnik · Sasha Hobson · Sephira Ryman · Andrei Vakhtin · Kiran Bhaskar · Gary A. Rosenberg
Frontiers in Aging
doi 10.3389/fragi.2026.1923046
Original Research
Published
Cognitive-behavioral phenotypes in FMR1 premutation carriers: a cross-population comparison with mild cognitive impairment
Nell Maltman · Jessica Greenlee · Kimberly D. Mueller · Barbara B. Fransway · James T. Shira · Davina Hammann · Sumi Lee · Hyeri Lee · Ali Naderi Malek
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1943587
Review
Published
Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder
Kazuhiko Yamamuro · Takahira Yamauchi · Manabu Makinodan
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1915506
Methods
Published
Personalized robotic interventions for apathy in dementia: the RAPHAel trial
Claudia Casadio · Vanessa Zanelli · Valentina Bettelli · Francesco Ricci · Lucrezia Grassi · Pietro Benvenuti · Erika Rovini · Giulia Smecca · Sara Isernia · Simone Salemme · Manuela Tondelli · Annalisa Chiari · Francesca Baglio · Filippo Cavallo · Fausta Lui · Francesca Benuzzi · Laura Fiorini · Antonio Sgorbissa · Giovanna Zamboni
Frontiers in Robotics and AI
doi 10.3389/frobt.2026.1913791
Original Research
Published
Association between preoperative cognitive impairment and perioperative neurocognitive disorders within 30 days after surgery in elderly patients: a secondary exploratory retrospective analysis
Keke Song · Ping He · Xiaoqi Zhao · Rongsheng Zhou · Yaomin Zhu · Xiaofei Liu · Xin Zhang
Frontiers in Aging
doi 10.3389/fragi.2026.1835897
Original Research
Published
The association between digital literacy and cognitive function in older adults: the multiple mediating roles of self-efficacy, social participation, and psychological resilience
Rui Ren · Reyisaimu Wumaierjiang · Rui Li · Rui Hou · Kangjia Yang
Frontiers in Aging
doi 10.3389/fragi.2026.1902964
Original Research
Published
Cognitive and behavioral benefits of newspaper reading in community-dwelling older adults: a feasibility randomized controlled trial
Mamoru Sato · Sawako Negoto · Shinya Nakano · Chihoko Urata · Tetsuya Ioji · Hideya Kodama · Emi Yoshimura · Yukinori Tasaki · Shinichiro Goroku · Kiichiro Morita · Yoshihisa Shoji
Frontiers in Aging
doi 10.3389/fragi.2026.1929793
Original Research
Published
Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum
Andrea Angarita-Rodríguez · Johan H. Largo-González · Julián Pérez-Mejía · Daniel Balcazar · Viviana Vargas-López · Jason A. Papin · Andrés Pinzón · Janneth González
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1897648
Original Research
Published
Home-based cognitive telerehabilitation in multiple sclerosis: differential cognitive trajectories according to baseline impairment severity
Gianna Carla Riccitelli · Rosaria Sacco · Francesca Beeching · Giulia Mallucci · Giulio Disanto · Claudio Gobbi · Chiara Zecca
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1894935
Review
Published
The potential of microbiome modulators to improve quality of life in cancer survivors through gut microbiome-immune interactions
Brandi C. Miller · Julia H. Hoover · Hariom Yadav · Shalini Jain
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1815079