Review
Published
Application of large language models in early screening of Alzheimer’s disease: a scoping review
Jianan Tian · Weidong Huang · Yongmei Wen · Yifan Liang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1906641
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Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 266 articles
Original Research
Published
A clustering approach based on neuropsychological testing to detect early signs of probable MCI among community-dwelling older adults
Rafael Mauti · Chiraz Chouk · Aymeric Guillot · Arnaud Peronin · Patrick Fargier · Pascal Chabaud
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1926431
Original Research
Published
Camk2d upregulation is associated with postoperative cognitive dysfunction in aged rats: pharmacological inhibition of CaMKII attenuates hippocampal neuroinflammation and neuronal apoptosis
Kaihua Wei · Shiwen Fan · Yujia Zhao · Xiaobin Cai · Xinlei Qin · Jingwen Zhai · Liping Xie
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1975677
Review
Published
Mechanisms and therapeutic prospects of short-chain fatty acids in neonatal hypoxic–ischemic encephalopathy via modulation of mitochondrial dysfunction and endoplasmic reticulum stress
Yinyu Wang · Lingjuan Gao · Yu Xu · Limei Niu · Xuan Tang · Yunxu Zhou · Xianhui Deng · Zhidan Bao
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1875196
Mini Review
Published
SIRT2 in metabolism, aging, and longevity
Menghui Li · Yihuan Dong · Wen Ren · Weixia Dong · Shaoping Ji
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1990670
Original Research
Published
Body weight–normalized resting metabolic rate and its associations with malnutrition and sarcopenia in hospitalized older adults: a cross-sectional study
Shan Jiang · Jie Zhao · Peng Chen · Lehui Chen · Weihong Chen · Zi Lin · Lin Kang · Hailong Li · Xia Zhao · Qiumei Wang
Frontiers in Nutrition
doi 10.3389/fnut.2026.1914763
Original Research
Published
Socioeconomic costs and health-related quality of life associated with oculopharyngeal muscular dystrophy
Ian C. Smith · Alyssa Grant · Lola E. R. Lessard · Homira Osman · Fien Oelbrandt · Hanns Lochmüller · Hugh J. McMillan · Gerald Pfeffer · Lawrence Korngut · Cynthia Gagnon · Stacey Lintern · Katherine A. Selby · Ari Breiner · Kednapa Thavorn · Jodi Warman-Chardon
Frontiers in Public Health
doi 10.3389/fpubh.2026.1918801
Systematic Review
Published
Outcomes of gastrostomy in children with neurological impairment: a systematic review
Mariam Kamel Ibrahim · Hafeeza Jummakhan · Malak Dawood · Mariam Siam · Minat Allah Alhusami · Sara Khan · Jonathan Mokhtar · Hani T. S. Benamer · Mohamed O. E. Babiker
Frontiers in Pediatrics
doi 10.3389/fped.2026.1963093
Review
Published
Gut microbiota, microbial metabolites, and mucosal barrier dysfunction in benign anorectal disorders and ulcerative colitis: shared mechanisms, clinical links, and precision interventions
Hexue Yuan · Maofang Zhao · Yunfen Wang · Chen Shen · Delong Liu · Chunxiao Wang · Jian Liu
Frontiers in Medicine
doi 10.3389/fmed.2026.1979206
Editorial
Published
Editorial: Advances in early detection, pathophysiology, and management of mild cognitive impairment
Edgar Vásquez-Carrasco · Cristian Sandoval-Vásquez · Pablo Valdés-Badilla
Frontiers in Medicine
doi 10.3389/fmed.2026.2007251
Review
Published
Periocular rejuvenation: current concepts and evidence-based management
Alessio Martucci · Flavia Quaranta Leoni · Matteo Di Marino · Enrico Romano
Frontiers in Medicine
doi 10.3389/fmed.2026.1943441
Review
Published
Functional single-cell omics in gynecological cancers immunotherapy: from heterogeneity dissection to clinical translation
Dong-mei Li · Kai-ge Pei · Bo-wen Yang · Ming-rong Qie · Jin-feng Xu · Lan Zhong · Liang Song
Frontiers in Immunology
doi 10.3389/fimmu.2026.1981010
Original Research
Published
Quercetin attenuates polystyrene nanoplastic-induced intestinal barrier injury through modulation of macrophage inflammatory responses
Jian Kang · Heng Yang · Yan Wang · Xin Zhang · Chunyang Zhu · Yanhong Zhou · Yanqin Li
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1973458
Original Research
Published
Depression, anxiety, and cognitive function in patients with ischemic cerebrovascular disease: a cross-sectional study based on the Montreal Cognitive Assessment
Weiwen Chen · Yinan Zhuo
Frontiers in Neurology
doi 10.3389/fneur.2026.1854573
Original Research
Published
Clinical study of isokinetic training with joint control tasks on lower limb function in stroke patients with proprioceptive impairment: a preliminary randomized controlled trial
Zhendong Zhang · Huixian Yu · Ping Li · Na Li · Yumei Zhang
Frontiers in Neurology
doi 10.3389/fneur.2026.1881854
Systematic Review
Published
Efficacy of digital interventions for patients with post-stroke aphasia: a systematic review and network meta-analysis
Junjie Shi · Yue Sun · Jingyi Zhang · Zeyu Yang · Jia Hu · Liang Zhi · Qingfang Zhang · Yulong Wang · Jianjun Long
Frontiers in Neurology
doi 10.3389/fneur.2026.1936067
Original Research
Published
Diagnostic delay length and disease severity are the main predictors of sleep apnea in acromegaly patients
Rosa Pirchio · Renata Simona Auriemma · Stefano Sanduzzi Zamparelli · Paola Bonavolontà · Claudia Merola · Angelo Canora · Claudia Pivonello · Alessandro Sanduzzi Zamparelli · Rosario Pivonello · Annamaria Colao
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1928818
Original Research
Published
Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and post-stroke depression in patients with acute ischemic stroke
Yu Yun · Jie Liu · Yaqiang Li
Frontiers in Psychiatry
doi 10.3389/fpsyt.2026.1882234
Editorial
Published
Editorial: Imaging biomarkers in neurodegenerative diseases: advances and challenges
Francesco Lanfranchi · Andrew R. Bender · Lucas Caldi Gomes
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.2009935
Hypothesis and Theory
Published
A SynNotch-PiggyBac gene circuit for inflammation-responsive IL-10 delivery in Alzheimer’s disease: a hypothesis and design framework
Suhani Gupta · Ronav Gupta
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1866161
Original Research
Published
TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology
Zheng Liu · Yuchen Yu · Yu Wang · Shuohan Ning · Tongshuai Huang · Jingqi Li · Sihan Fan · Chaolong Lu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1920487
Mini Review
Published
Pain, cognition, and culture in dementia research: a critical synthesis of empirical and methodological literature
Rimsha Taqdees · Tom Mercer · Abigail Olubola Taiwo
Frontiers in Pain Research
doi 10.3389/fpain.2026.1797629
Review
Published
Tele-optometry for eye disease screening: a scoping review of context-dependent diagnostic performance and limitations for large-scale implementation
Kingsley Ekemiri · Nigel St Rose · Chioma Ekemiri · Ebere Obinna · Chigozie Ekenze
Frontiers in Digital Health
doi 10.3389/fdgth.2026.1871351
Original Research
Published
Early changes in CT-derived quantitative flow ratio after transcatheter aortic valve replacement: a serial coronary physiological assessment
Lieyou Li · Yonghui Yu · Xinjie Zeng · Lijun Luo · Zhongwei Shi · Linyan Chen · Feng Hu · Lin Fan
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2026.1902728
Study Protocol
Published
Sitting Baduanjin-based rehabilitation programme following endovascular therapy in patients with chronic limb-threatening ischemia: protocol for a WeChat mini program-assisted multicentre randomized controlled trial
Jiayi Song · Li Fu · Xiaomei Fang · Haiyan Chen · Lian Wang · Liang Xing · Huanping Liu · Yun Xu
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2026.1921616
Original Research
Published
Development and external validation of an explainable machine learning model for identifying depressive symptoms in middle-aged and older adults with low haemoglobin: a prediction-model study
Qilong Wang · Juan He · Siheng Ma · Jianpeng Zhao · Jingjing Zong · Dongmei Ma · Sha Liu · Lei Zhang · Xin Qi · Dongrong Zhao
Frontiers in Nutrition
doi 10.3389/fnut.2026.1846276
Case Report
Published
Case Report: A severe case of human parechovirus encephalitis in a neonate
A. M. Grimm · A. Heep · Christiaan Peter Sentner · K. M. Fiedler
Frontiers in Pediatrics
doi 10.3389/fped.2026.1889734
Original Research
Published
Factors associated with reduced kidney function in hospitalized children with dehydration
Dovilė Ruzgienė · Georgios Stathoglou · Inga Ivaškevičienė · Augustina Jankauskienė
Frontiers in Pediatrics
doi 10.3389/fped.2026.1917450
Original Research
Published
Caregiver-reported oral health-related quality of life in children with Mowat–Wilson syndrome: a comparative study
Silvia Cirio · Claudia Salerno · Aesha Allam · Giulia Zambon · Araxi Balian · Maria Grazia Cagetti
Frontiers in Dental Medicine
doi 10.3389/fdmed.2026.1953280
Study Protocol
Published
Clinical profiles, referral patterns and low vision aid prescribing across four rehabilitation centres in Ghana: protocol for a multicentre retrospective record review
Kwadwo Owusu Akuffo · Josephine Ampong · Josephine Ampomah Boateng · Caleb Ofosu Yeboah · Lovinger Ato Quansah · Richard Atakora Baafi · Edward Aboagye Yeboah · Isaiah Osei Duah Junior · Sylvia Agyekum · Sylvester Kyeremeh · David Ben Kumah · Albert Kwadjo Amoah Andoh · Emmanuel Tettey Doku · Gabriel Kwaku Agbeshie · Samuel Oteng Brako · Kenneth Bempah Karikari · Nana Akwasi Owusu Mensah · Eldrick Adu Acquah · Ellis Sarpong Mainuh · Maame Abena Kesewah Boaitey · Bright Owusu Prempeh · Louis Oteng-Gyimah · Afua Asantewaa Nkansah · Patience Boatemaa-Twum · Henry Owusu Bota · Josephine Boakye Owusu · Golda Dokuaa Kwapong · Nicholas Sarpong · Hornametor Yao Afake · Werner Eisenbarth
Frontiers in Medicine
doi 10.3389/fmed.2026.1936778
Original Research
Published
Berberine-fluconazole synergy against drug-resistant Candida albicans : association with disruption of the Ire1-mediated UPR pathway
Daifan Yue · Dongming Zheng · Zhen Song · Dongmei Li · Yan Li
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1965937
Study Protocol
Published
Effect of epidural spinal cord stimulation combined with personalized neurorehabilitation in chronic motor-complete spinal cord injury: study protocol for the phase II single-arm feasibility RESTORES (RESToration Of Rehabilitative function with Epidural spinal Stimulation) trial
Kai Rui Wan · Zhi Yan Valerie Ng · Seng Kwee Wee · Fatimah Misbaah · Wen Li Lui · Min Wee Phua · Tegan Plunkett · Neethu Robinson · Aung Aung Phyo Wai · Cuntai Guan · Ananda Sidarta · Rosa Qi Yue So · Brian Premchand · Kezia Susanto · Luca Cocchi · Seyed Ehsan Saffari · Rui Xin Justin Ker · Wai Hoe Ng
Frontiers in Neurology
doi 10.3389/fneur.2026.1967078
Original Research
Published
A machine learning model for predicting cognitive improvement after scalp cluster needling therapy in patients with post-stroke mild cognitive impairment
Yican Hao · Xia Wei · Pingli Zhao · Hewei Qin
Frontiers in Neurology
doi 10.3389/fneur.2026.1884682
Original Research
Published
Polysomnographic and nocturnal heart rate correlates of cognitive impairment in Parkinson’s disease: a cross-sectional study
Zhang Linwei · Lv Pu · Wang Lu · Zhang Xiangfei · Wang Kang · Jin Miao
Frontiers in Neurology
doi 10.3389/fneur.2026.1913495
Study Protocol
Published
Cognitive remediation in schizophrenia: efficacy and role of neuroplasticity in “top-down” and “bottom-up” mechanisms—a randomized, double-blind, treatment-as-usual-controlled study protocol
Juan I. Cifuentes · Constanza Orellana · Diego Tello · Cristian Ramírez · Catalina Prieto · Jessica M. Guasti · Rodrigo R. Nieto
Frontiers in Psychiatry
doi 10.3389/fpsyt.2026.1936475
Mini Review
Published
Exercise for the negative symptoms of schizophrenia: a review
Charles Trevelyan · Hina Mohsin
Frontiers in Psychiatry
doi 10.3389/fpsyt.2026.2001262
Review
Published
Screen exposure and cognitive outcomes in school-aged children and adolescents: a narrative review through the lens of Cognitive Load Theory
Hiya Al Kalbani · Erin Kitt-Lewis
Frontiers in Developmental Psychology
doi 10.3389/fdpys.2026.1958088
Review
Published
Neuromodulatory interventions for Alzheimer’s disease
Ruofan Wang · Botao Zhu · Qingda Guo · Jun Steed Huang · Wandong Zhang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1925914
Original Research
Published
Immediate anxiety-reducing effects of multisensory virtual reality reminiscence therapy in older adults with a wide range of cognitive functions: a pilot study using electrophysiological measures
Keita Ueno · Kazuyuki Niki · Hiroyuki Tanaka · Takeshi Okuda · Daisuke Iwai · Kosuke Sato · Yasuo Naito · Toshinori Ito · Ryouhei Ishii
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1958403
Original Research
Published
Welfare assessment in pasture-based and confined dairy farms in São Paulo State, Brazil: a descriptive multi-case study identifying health and hygiene constraints
Ana Luiza Mendonça Pinto · Robson Mateus Freitas Silveira · Ayres Gustavo Dias Nogueira · Iran José Oliveira da Silva
Frontiers in Animal Science
doi 10.3389/fanim.2026.1985819
Original Research
Published
Influenza A (H1N1)pdm infection exacerbates behavioral, cognitive, and synaptic impairments in 5xFAD mice
Anastasiya Rakovskaya · Alexey Lozhkov · Valeria Tverdokhlebova · Yana Zabrodskaya · Egor Vinokurov · Valeria Kirenskaya · Alexander Erofeev · Angelika Garshinina · Valeria Zryacheva · Anna Shtro · Ekaterina Pchitskaya · Olga Vlasova · Ekaterina Elpaeva · Pavel Dav · Ilya Bezprozvanny · Andrey Vasin
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1955816
Case Report
Published
Combined intermittent theta-burst stimulation and functional electrical stimulation as adjuncts to intrathecal baclofen in hereditary spastic paraplegia type 11: a case report
Haodong Zhang · Jie Shen · Yanping Qu
Frontiers in Rehabilitation Sciences
doi 10.3389/fresc.2026.1942850
Case Report
Published
Case Report: Case series: growth hormone replacement for severe growth hormone deficiency during BRAF inhibitor therapy in pediatric low-grade glioma: long-term follow-up
Marta Panciroli · Antonio Verrico · Marco Crocco · Sara Cencioni · Chiara Morreale · Antonia Ramaglia · Valentina Iurilli · Gianluca Piccolo · Claudia Milanaccio · Mohamad Maghnie · Natascia Di Iorgi
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1940850
Original Research
Published
“I feel like I'm in a dream”: a qualitative investigation of the lived experience of Visual Snow Syndrome
Amy Claire Thompson · Georgia F. Caruana · Jacob M. Paul · Olivia Carter · Jason D. Forte
Frontiers in Neurology
doi 10.3389/fneur.2026.1973126
Case Report
Published
Case Report: Beyond chronicity: sustained multidimensional response to spinal cord stimulation three decades after traumatic spinal cord injury
Andrea Blažević · Petar Marčinković · Fadi Almahariq · Sven Krušić · Domagoj Dlaka · Darko Chudy · Marina Raguž · Tonko Marinović
Frontiers in Pain Research
doi 10.3389/fpain.2026.1969355
Perspective
Published
Soil contaminants at the environment-health interface require function-centered risk assessment
Sylvester Chibueze Izah · Ebinyo Rebecca Aseibai · Vivian Ibienebakabobo Promise · Matthew Chidozie Ogwu
Frontiers in Soil Science
doi 10.3389/fsoil.2026.1954312
Original Research
Published
Graded multisensory neurofeedback via the iNems system for comprehensive upper limb recovery after stroke: a multiple baseline study
Takayuki Kodama · Ken Kitai · Yasuhisa Mizomoto · Kaichi Nishigaya · Shoutarou Hashimoto · Riona Hiraga · Satomi Shimizu · Miki Kawabata · Yuumi Hirabayashi · Keita Ikesue · Hazime Kako · Syouta Yasui · Hiroki Ito · Kazuhei Nishimoto · Osamu Katayama · Hideaki Yamaguchi · Hikaru Nagano · Mari Inoue · Shin Murata · Kiichiro Morita
Frontiers in Human Neuroscience
doi 10.3389/fnhum.2026.1938622
Original Research
Published
College mental health and the digital care transition: national trends in distress, help-seeking, and technology-mediated access, 2020–2025
Génesis Carolina Arévalo Guadalupe · Luis Alexander Gamboa Tama · Joaquín Estalín Gamboa Tama
Frontiers in Digital Health
doi 10.3389/fdgth.2026.1963340