Original Research
Published
Controlled sol-gel nanoassembly of Au 25 (SR) 18 nanoclusters for structural and functional integration
Mahdi Hesari · Marysa Colvin
Frontiers in Chemistry
doi 10.3389/fchem.2026.1982602
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Showing 96 articles
Review
Published
Calcium-dependent conformational transitions and ligand binding regulation of C-reactive protein: a comprehensive review
Bin Cheng · Zhi-Xin Yao · Guo-Qiang Wu
Frontiers in Immunology
doi 10.3389/fimmu.2026.1963529
Original Research
Published
Taxifolin alleviates podocyte injury and macrophage chemotaxis associated with diabetic nephropathy by directly targeting RBP1 identified via multi-omics and machine learning
Zi-Xuan Wang · Wen-Xuan Wang · Qiong-Dan Liang · Ling-Dong Kong
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1933167
Original Research
Published
Resistance to thyroid hormone alpha associated with a novel THRA ligand-binding domain variant: familial clinical, biochemical, skeletal, and exploratory cerebral FDG-PET/CT metabolic findings
Denisse Mata-Salgado · Juan José Morales-Suárez · Alfredo Adolfo Reza-Albarrán · Rodrigo Hernández-Ramírez · Miguel Angel Corza-Ayala · José Antonio Cienfuegos-Alvear · Ana María González-Jaimes · Iván Martínez-Duncker · Carmen Alaez-Verson
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1891019
Hypothesis and Theory
Published
A SynNotch-PiggyBac gene circuit for inflammation-responsive IL-10 delivery in Alzheimer’s disease: a hypothesis and design framework
Suhani Gupta · Ronav Gupta
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1866161
Brief Research Report
Published
Identification of critical sites for glycine- and cesium-dependent activation of the RNA-edited glycine receptor α3L
Yulia Novykova · Steffen Fricke · Jochen C. Meier
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1918246
Original Research
Published
Siderophores and siderophore-associated metabolites from Antarctic Pseudomonas sp. ANT_H12B contribute to iron and phosphorus mobilization in soils with contrasting properties
Xiaomeng Chen · Marcin Musiałowski · Klaudia Dębiec-Andrzejewska · Robert Stasiuk · Luisella Celi · Michela Schiavon · Maria Martin · Silvia Celletti
Frontiers in Soil Science
doi 10.3389/fsoil.2026.1960451
Mini Review
Published
Biomarker-guided immunotherapy in osteosarcoma: from immune microenvironment profiling to patient stratification and combination strategies
Qingqing Li
Frontiers in Medicine
doi 10.3389/fmed.2026.1987146
Case Report
Published
Durable partial response with low-dose, intermittent nivolumab in combination with gemcitabine for high PD-L1 metastatic triple-negative breast cancer: a case report
Po Lin Ooi · Jamin Munchar Elias · Francis Yew Fu Tieng
Frontiers in Oncology
doi 10.3389/fonc.2026.1964934
Original Research
Published
In silico evaluation of potential penicillin-binding protein 2 (PBP2) inhibitors from Borassus flabellifer haustorium against cephalosporin-resistant Neisseria gonorrhoeae
Udhaya Rajasekaran · T. B. Sridharan
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1918221
Original Research
Published
Histopathology-guided spatial transcriptomic analysis identifies an ECM-associated stromal pattern in lacrimal gland adenoid cystic carcinoma with complementary proteomic and functional analyses
Rong Luan · Difei Zuo · Yeqing Wang · Meixia Jiang · Xun Liu · Limin Zhu · Tingting Lin
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1949721
Review
Published
Prostate cancer: advancements in targeted therapies
Ilesha Ewart · Manreet Randhawa
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1924299
Review
Published
Investigating protein conformational ensembles by native mass spectrometry and complementary biophysical techniques—the case of α-synuclein
Stefania Brocca · Erika Ponzini · Carlo Santambrogio · Rita Grandori
Frontiers in Biophysics
doi 10.3389/frbis.2026.1887194
Review
Published
Gut microbiota-derived small molecules, peptides, and proteins in GPCR signaling: current evidence for β-arrestin involvement
Yushan Hu · Yiru Liu · Haiyan Yao · Siteng Wang · Yice Gao · Ruixue Li · Hui Sun
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1979411
Original Research
Published
Nanoprobe XRF analysis reveals the intracellular distribution of organometallic rhenium complexes with different directing ligand
C. Rumancev · S. K. Vellas · A. Gräfenstein · D. Obitz · J. Garrevoet · G. Falkenberg · N. Metzler-Nolte · A. Rosenhahn
Frontiers in Chemical Biology
doi 10.3389/fchbi.2026.1903385
Original Research
Published
Integrating transcriptomic analysis and experimental validation unravels autophagy- and lactylation-related gene signatures in acute myocardial infarction
Jun Peng · Li Chen · Lizhen Liu · Xiangdong Xu · Huiwen Song
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2026.1814910
Review
Published
Context-dependent oxytocin receptor signaling: from molecular architecture to transcript-level receptor engineering
Benjamin Jurek · Julia J. Winter · Daniel S. Quintana
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1938379
Perspective
Published
Advances in enhanced sampling simulations of G-protein-coupled receptors
Keya Joshi · Victor Ayo Adediwura · Yinglong Miao
Frontiers in Chemical Biology
doi 10.3389/fchbi.2026.1943336
Original Research
Published
Development of novel Copper(II)–hydrazone complexes for targeting the inhibition of human osteosarcoma growth
Lucía Santa Maria de la Parra · Olivia Espindola-Moreno · Matías H. Assandri · Gustavo A. Echeverría · Oscar E. Piro · Gonzalo Scalese · Ignacio E. León
Frontiers in Chemistry
doi 10.3389/fchem.2026.1897476
Mini Review
Published
Electrochemical scanning tunneling microscopy as a tool for probing protein function: from electron transfer to molecular recognition and chemosensation
Josep Samitier · Anna Lagunas
Frontiers in Biophysics
doi 10.3389/frbis.2026.1945182
Review
Published
Neu5Gc and beyond: sialylation at the innate immune and thromboinflammatory interface of xenotransplantation
Jae Young Kim
Frontiers in Transplantation
doi 10.3389/frtra.2026.1968710
Review
Published
Mapping dynamics in neuronal activation and molecular connectivity with functional PET
Andreas Hahn · Murray B. Reed · Pia Falb · Matej Murgaš · Christian Milz · Sarah M. Tüchler · Sebastian Klug · Godber M. Godbersen · Rupert Lanzenberger
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1920555
Original Research
Published
Virtual screening of phytochemicals against multiple protein targets of Alzheimer’s disease
Samuel Mesfin · Naamah Bloch · Abraham O. Samson
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1922953
Original Research
Published
Integrated computational investigation of Glycosmis pentaphylla -derived compounds against major venom proteins of Daboia russelii
Sana S. Hussain · Danie J. Kingsley
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1906533
Perspective
Published
Peering beyond the fourth wall: should protein quaternary structure be a state space?
Daniela Diana · Yimon Aye · Marcus J. C. Long
Frontiers in Biophysics
doi 10.3389/frbis.2026.1923311
Perspective
Published
Bioaminergic signaling in parasitic flatworms: a perspective for linking GPCRs to behavior and drug discovery
Erika Bistran · M. Evelyn Carpenter · Daniel J. Sprague
Frontiers in Parasitology
doi 10.3389/fpara.2026.1933406
Original Research
Published
Immunoinformatics-guided design and in silico evaluation of BAFF- and APRIL-adjuvanted multi-epitope vaccine candidates against human metapneumovirus
Reham M. Alahmadi · Maaweya Awadalla · Halah Z. Al-Rawi · Ayman Mubarak · Wafa Ali Eltayb · Mohnad Abdalla · Han Yu · Bandar Alosaimi
Frontiers in Virology
doi 10.3389/fviro.2026.1949694
Original Research
Published
Enzyme-mediated site-specific functionalization of mRNA-containing TMV nanorods produced in yeast
Jerrell Tisnado · Ana Luisa Duran Meza · David Silverio Moreno Gutierrez · Nina M. Harpell · Alyssa Cruz · Charles M. Knobler · William M. Gelbart
Frontiers in Virology
doi 10.3389/fviro.2026.1955107
Review
Published
GPCR signaling systems facilitate precision interventions for multi-oncology therapy
Ashley Del Pozo · Mia Pardo · Tabitha Boeringer · Carter J. Craig · Ramzia Sorathia · Madeline Millican · Stuart Maudsley
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1940022
Original Research
Published
Active targeting towards bone cancer and metastases by pamidronate-bridged dinuclear platinum(II) complexes
Anna Maria Di Cosola · Alessandra Barbanente · Luisa D’Anna · Simona Rubino · Alessio Terenzi · Mauro Niso · Nicola Margiotta
Frontiers in Chemistry
doi 10.3389/fchem.2026.1945537
Review
Published
Next-generation nanomedicine for cancer therapy: advances, challenges, and future perspectives
Biswajit Mohanty · Puja Saikia · Piyush Pandey · Chira R. Bhattacharjee
Frontiers in Chemistry
doi 10.3389/fchem.2026.1920337
Original Research
Published
Exploratory scaffold hopping strategies led to identification of novel histamine H 3 and H 4 receptor ligands
Flávia B. Lopes · Denise Mönnich · Gustavo A. B. Fernandes · Steffen Pockes · João Paulo S. Fernandes
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1944403
Original Research
Published
Electroacupuncture alleviates inflammatory pain by modulating the CXCL1/CXCR2 signaling axis in the spinal cord dorsal horn of rats
Xiazhen Xu · Ziyan Fang · Kaihua Song · Yang Shen · Chenxin Jiang · Mengchao Xu · Shouhai Hong
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1880288
Review
Published
Smart biomaterials for precision drug delivery: emerging strategies for site-specific targeting and controlled therapeutic release
Sivakumar Singaravelu · Rajkamal Balu · Chinnaiyan Senthilkumar · Jayabalan Jayaprakash
Frontiers in Biomaterials Science
doi 10.3389/fbiom.2026.1912922
Original Research
Published
Palmitoylation-related lncRNAs link molecular signaling, immune remodeling, and tumor progression in glioma: prognostic modeling and functional validation of LYRM4-AS1
Juan Xu · Chen Zhang · Lingling Pu · Xiaoyang Zhu · Xiaoan Sheng · Juanjuan Dong · Miaomiao Song · Chao Wang
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1901839
Review
Published
Innovative nanomedicine strategies for precision-controlled targeted drug delivery: recent preclinical progress
Ashna Sureshkumar · Prakash Balu
Frontiers in Biomaterials Science
doi 10.3389/fbiom.2026.1916503
Review
Published
Quantum computing in drug discovery
Harshraj Gadbail · Rajendra Rewatkar · Nishant Jumde · Mrinal Manker · Pratik Nagre · Sujal Zade
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1815176
Original Research
Published
Revealing RELL1 signaling relying on the phosphoregulatory network analysis
Pathiyil Sajini Sekhar · Diya Sanjeev · Amal Fahma · Suhail Subair · Athira Perunally Gopalakrishnan · Prathik Basthikoppa Shivamurthy · Rajesh Raju · Sowmya Soman
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1939325
Original Research
Published
Computational insights into synergistic mechanisms of PD-901 and 5-azacitidine targeting PTPN11 (SHP2) E76K mutation in juvenile myelomonocytic leukemia
Abeer M. Al-Subaie · Balu Kamaraj
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1887328
Original Research
Published
Benchmarking protein-ligand co-folding across Nav, Cav and Kv-family channels
Yu Zhu · Taufiq Rahman
Frontiers in Biophysics
doi 10.3389/frbis.2026.1937302
Review
Published
Artificial intelligence across oncologic theranostics: evidence for patient stratification, dosimetry, and adaptive radiopharmaceutical therapy
Mallareddy Banala · Shabbir Ezuddin · Mark Foley · Russ Kuker
Frontiers in Nuclear Medicine
doi 10.3389/fnume.2026.1935247
Review
Published
Decoding RAGE in diabetes: a pathogenic signaling hub modulated by decoy receptors in diabetic complications
Yupa Srithongchai · Ai Harashima · Seiichi Munesue · Kumi Kimura · Yu Oshima · Mariko Tanaka · Hiroya Takahashi · Pathitta Sakulsak · Chisato Uramoto · Nontaphat Leerach · Yasuhiko Yamamoto
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1854214
Hypothesis and Theory
Published
Relative Sertoli-cell FSH hyporesponsiveness as a potential contributor to sperm DNA fragmentation: a hypothesis-driven narrative review and proposal of the FERTILE framework
Hussein Kandil
Frontiers in Urology
doi 10.3389/fruro.2026.1915445
Original Research
Published
Molecular dynamics simulation of the truncated NMDA receptor in a partially restrained active-like state
Xing Liu · Wenjun Zheng
Frontiers in Chemical Biology
doi 10.3389/fchbi.2026.1894245
Original Research
Published
Organometallic complexes with electron rich metal centers promise efficient and selective conversion of methane to methanol: proof of principle computational study
Joseph A. Olaniyan · Daniel Pacheco · Evangelos Miliordos
Frontiers in Catalysis
doi 10.3389/fctls.2026.1881586
Original Research
Published
Waste PET-derived BDC-ZIF-8 as an electrolyte-retaining filler for NPBI-based ion-solvating mixed-matrix membranes in alkaline water electrolysis
Sang Jeong Park · Jongsu Seo · Yu-Ri Lee · Young-Woo Choi · Jungkyu Choi · Jae Hun Lee
Frontiers in Membrane Science and Technology
doi 10.3389/frmst.2026.1892925
Original Research
Published
Spectral analysis and AI/ML-based data-driven approaches for enhanced protein conformation selection and prediction in drug discovery
Shivangi Gupta · Vineetha Menon · Jerome Baudry
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1805731
Review
Published
Beyond the hallmarks of cancer: enabling technologies reshaping cancer diagnosis, prevention, and treatment
Sarfaraz K. Niazi
Oncology Reviews
doi 10.3389/or.2026.1804447