Articles

Showing 162 articles

• Original Research

  Published 12 October 2026

  Identification and validation of biomarkers related to oxidative stress in pediatric sepsis utilizing WGCNA and multiple machine learning algorithms

  Yumeng Liu · Gang Luo

  Frontiers in Bioinformatics

  doi 10.3389/fbinf.2026.1745381

• Review

  Published 12 October 2026

  From constitutive killing to microenvironment-activated antimicrobial activity: a critical narrative review of antimicrobial dental materials for caries prevention

  Xiwen Xin · Ziying Tang · Yuejia Deng · Yulong Zhang · Hai Zhang · Bennett T. Amaechi · Andre V. Ritter · Alvin G. Wee · Justin Kaspar · Jing Zhao · Andréa Ferreira Zandoná · Xuelian Huang

  Frontiers in Cellular and Infection Microbiology

  doi 10.3389/fcimb.2026.1983359

• Mini Review

  Published 12 October 2026

  Modulation of Toll-like receptor signaling by intestinal bacteria in colorectal cancer

  Shuang Wang · Dongliang Chen · Dawei Yang · Lei Gao · Yifan Zhang

  Frontiers in Cellular and Infection Microbiology

  doi 10.3389/fcimb.2026.1963456

• Review

  Published 12 October 2026

  Bridging molecular and heterogeneous catalysis: metallolinker-assembled and post-synthetically metalated covalent organic frameworks for photocatalytic CO 2 reduction

  Yuan-Hui Zhong · Lai-Hon Chung

  Frontiers in Chemistry

  doi 10.3389/fchem.2026.1976872

• Review

  Published 12 October 2026

  Plant-derived extracellular nanovesicles in musculoskeletal repair and functional rehabilitation: mitochondrial–immune–metabolic regulation

  Ningning Zhu · Ningrui Wang · NaNa Zhou · Baodong Ye · Jingjing Liu

  Frontiers in Chemistry

  doi 10.3389/fchem.2026.1968520

• Hypothesis and Theory

  Published 12 October 2026

  Influencing the exposome, patient macroenvironment, tumor microenvironment through-line to improve clinical outcomes

  Samuel F. Yanuck · Neil E. Alexis

  Frontiers in Oncology

  doi 10.3389/fonc.2026.1929067

• Review

  Published 12 October 2026

  Spatial architecture shapes programmed cell death-associated immune niches and therapeutic resistance in clear cell renal cell carcinoma

  Yu Yin · Junlong Wang · Dengxiong Li · Dandan Qiu

  Frontiers in Oncology

  doi 10.3389/fonc.2026.1952158

• Review

  Published 12 October 2026

  Personalized in situ bioprinting of skin: designing a blueprint for clinical translation

  Rana Elmaalawy · Abdulrahman Khaled · Mona Marei · Rania Elbackly

  Frontiers in Bioengineering and Biotechnology

  doi 10.3389/fbioe.2026.1895767

• Review

  Published 12 October 2026

  Metabolic sensing in 3D models of pancreatic ductal adenocarcinoma: probing pH, oxygen, and lactate dynamics to decode chemoresistance

  Anna Chiara Siciliano · Stefania Forciniti · Helena Iuele · Federica Carnevali · Giuseppe Gigli · Loretta L. del Mercato

  Frontiers in Bioengineering and Biotechnology

  doi 10.3389/fbioe.2026.1926254

• Systematic Review

  Published 12 October 2026

  The CXCL12/CXCR4 axis in breast cancer-associated fibroblasts: a transcriptome analysis and systematic literature review

  Sergey Vladimirov · David Sergeevichev · Maria Bogachek · Alina Kazakova · Anastasia Leonteva · Vladimir Richter · Anna Nushtaeva

  Frontiers in Bioengineering and Biotechnology

  doi 10.3389/fbioe.2026.1920541

• Hypothesis and Theory

  Published 12 October 2026

  Treating a systemic disease as a local one: failure points of current pancreatic cancer management and a multimodal, biology-guided framework for redesign

  Patrick E. Sewell

  Frontiers in Oncology

  doi 10.3389/fonc.2026.1941793

• Review

  Published 12 October 2026

  Obesity-driven inflammation and immune dysregulation in cancer development and progression

  Pritika Pandey · Jeb F. Struder · Erika T. Rezeli · Evan M. Paules · Stephen D. Hursting · Michael F. Coleman · Kristin A. Altwegg

  Frontiers in Oncology

  doi 10.3389/fonc.2026.1947958

• Perspective

  Published 12 October 2026

  From macrofungal polysaccharides to precision microbial immunotherapy: reprogramming the tumor microenvironment through immunometabolic and gene-regulatory pathways

  Kingsley Excel Dunga · Sylvester Chibueze Izah · Ebinyo Rebecca Aseibai · Matthew Chidozie Ogwu · Vivian Ibienebakabobo Promise · Nsikak Godwin Etim · Irene Nneka Ohanusi

  Frontiers in Oncology

  doi 10.3389/fonc.2026.1966586

• Perspective

  Published 12 October 2026

  Resistance in the edges: a relational framework for treatment resistance in genitourinary cancers

  Daniele Silva Lacerda · Rosiane Batista Mastelari · Tiago Veiras Collares

  Frontiers in Oncology

  doi 10.3389/fonc.2026.1974982

• Original Research

  Published 12 October 2026

  Multi-cohort screening of PANoptosis-related genes reveals PARP1 as a key target, and AZD5305 exerts anti-tumor effects in neuroblastoma

  Shujun Shi · Zhaoxia Zhang · Junyi Luo · Zhaoying Wang · Tao Mi · Liming Jin · Xiangpan Kong · Jinkui Wang · Junhong Liu · Li Wang · Dawei He

  Frontiers in Oncology

  doi 10.3389/fonc.2026.1903085

• Mini Review

  Published 12 October 2026

  Autophagy as a potential link between progesterone responsiveness and endometrial immune function in recurrent implantation failure

  Li Guo · Jinghong Xie · Mengyu Wang · Shuang Ma · Xinyan Zhang · Yu Guan

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1990439

• Review

  Published 12 October 2026

  Functional single-cell omics in gynecological cancers immunotherapy: from heterogeneity dissection to clinical translation

  Dong-mei Li · Kai-ge Pei · Bo-wen Yang · Ming-rong Qie · Jin-feng Xu · Lan Zhong · Liang Song

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1981010

• Review

  Published 12 October 2026

  Extracellular vesicles in colorectal cancer: M2 polarization, bidirectional regulation of CAFs, metastasis, and treatment

  Xiaoling Wang · Zhaohua Lai · Hanlu Chen · Mei Yang · Huapei Kang · Fangsheng Wang · Junyun Huang · Yuxin Deng

  Frontiers in Cell and Developmental Biology

  doi 10.3389/fcell.2026.1980961

• Review

  Published 12 October 2026

  Tumor antigens across cancer progression: from immune recognition and selection to precision cancer immunotherapy

  Stanley P. Leong

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1939919

• Review

  Published 12 October 2026

  Halogenated and metallic scaffolds as novel efflux pump inhibitors: mechanistic insight in overcoming antimicrobial and cross-domain resistance

  Manaf AlMatar · Raja Lakhal · Kamaleldin H. Kamaleldin · Arig Ibrahim-Hashim

  Frontiers in Microbiology

  doi 10.3389/fmicb.2026.1923157

• Mini Review

  Published 12 October 2026

  Bioactive small-molecule gas delivery for enhanced bone regeneration: modulation of cellular signaling and remodeling of the regenerative microenvironment

  Zhou Zhong · Biao Cao · Xin Duan

  Frontiers in Cell and Developmental Biology

  doi 10.3389/fcell.2026.1992564

• Original Research

  Published 12 October 2026

  Coordination of photosynthetic performance and leaf N:P stoichiometry under fluctuating coastal environmental conditions in Bolboschoenoplectus mariqueter

  Jiayuan Wang · Lianjiang Lyu · Xuexin Shao · Tonggui Wu · Fang Zhou · Long Zhang · Wenwen Yuan

  Frontiers in Plant Science

  doi 10.3389/fpls.2026.1911028

• Review

  Published 12 October 2026

  Glutamine metabolic reprogramming in acute and chronic kidney diseases: mechanistic insights and therapeutic implications

  Ruotong Xu · Jin Zhao · Minna Liu · Yifan Qiao · Xiaoxuan Ning · Shiren Sun

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1939528

• Review

  Published 12 October 2026

  Macrophage functional plasticity in periodontitis: microenvironmental regulation, disease progression, and therapeutic targeting

  Ziqi Gu · Xinyu Li · Gulinur Awuti

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1973755

• Review

  Published 12 October 2026

  Metabolic-epigenetic regulation of the HBV cccDNA reservoir: pathways underpinning viral persistence

  Qing Peng · Liyuan Hao · Shenghao Li · Fei Yu · Na Li · Fanghang Ye · Xiaoyu Hu

  Frontiers in Microbiology

  doi 10.3389/fmicb.2026.1968789

• Review

  Published 12 October 2026

  Nutritional regulation of the tumor immune microenvironment: metabolic mechanisms, immunotherapy response, and nursing implications

  Danwei Zhong · Congjue Li · Zunyao Xiao

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1938564

• Review

  Published 12 October 2026

  Tebentafusp induces systemic immune activation, but tumor immune remodeling remains incompletely validated: a narrative review in metastatic uveal melanoma

  Francesca Rifaldi · Filippo De Braud · Michele Del Vecchio · Lorenza Di Guardo

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1934256

• Mini Review

  Published 12 October 2026

  Spatial heterogeneity in glioblastoma: linking single-cell and spatial multi-omics to vaccine immunotherapy

  Juan Yuan · Yong Liu

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1921816

• Brief Research Report

  Published 12 October 2026

  Distinct spatial immune architectures in tumor and tumor-adjacent tissues of early-stage non-small cell lung cancer

  Isabella Polic · Claudio Arrechedera · Jared K. Slone · Amanda Montoya · Emily Bontekoe · Peixin Jiang · Anika Patel · Tatiana V. Karpinets · Xiaogang Wu · Xingzhi Song · Qianyun Luo · Heladio Ibarguen · Auriole Tamegnon · Mei Jiang · Cara Haymaker · Annikka Weissferdt · Ara A. Vaporciyan · Lydia E. Kavraki · Tina Cascone · Ignacio Wistuba · Luisa Maren Solis Soto · John V. Heymach · Jianjun Zhang · Don L. Gibbons · Alexandre Reuben

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1981839

• Review

  Published 12 October 2026

  Progress in research on gut microbiota regulation of tumorigenesis, progression, and therapeutic response via inflammatory cytokines

  Yan Liu · Dan Zang · Jun Chen

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1922678

• Review

  Published 12 October 2026

  Calcium-dependent conformational transitions and ligand binding regulation of C-reactive protein: a comprehensive review

  Bin Cheng · Zhi-Xin Yao · Guo-Qiang Wu

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1963529

• Original Research

  Published 12 October 2026

  SCD1 inhibition promotes lipid peroxidation and enhances anti-PD-1 response in triple-negative breast cancer

  Quentin Herrera Garfia · Aurélien Azam · Eric Bonneil · Laetitia Montero-Ruiz · Mohsen Momeni · Mohammad Farran · Robin Jehay · Nor Eddine Sounni

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1843935

• Original Research

  Published 12 October 2026

  Tumor-educated macrophages promote ferroptosis inhibition in pancreatic cancer via activating the p62-KEAP1-NRF2 pathway

  Shouying Li · Dongxue Qi · Hanyang Yi · Lina Yang · Tonglei Xu · Wenkai Zhou · Weidong Xu · Ziheng Xu · Haodong Tang · Fangliang Xie · Chunfang Zhang · Xuyang Liang

  Frontiers in Immunology

  doi 10.3389/fimmu.2026.1938077

• Review

  Published 12 October 2026

  Flavonoids in cancer pharmacology: molecular mechanisms, tumor microenvironment regulation, and drug resistance

  Zhengyuan Yu · Zhanyi Zhou · Ni Yin · Hongcheng Ge

  Frontiers in Pharmacology

  doi 10.3389/fphar.2026.1969337

• Correction

  Published 12 October 2026

  Correction: Effect and mechanism of Emodin on mouse myeloid-derived suppressor cells

  Frontiers Production Office

  Frontiers in Pharmacology

  doi 10.3389/fphar.2026.2001607

• Original Research

  Published 9 October 2026

  TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology

  Zheng Liu · Yuchen Yu · Yu Wang · Shuohan Ning · Tongshuai Huang · Jingqi Li · Sihan Fan · Chaolong Lu

  Frontiers in Aging Neuroscience

  doi 10.3389/fnagi.2026.1920487

• Mini Review

  Published 9 October 2026

  Biomarker-guided immunotherapy in osteosarcoma: from immune microenvironment profiling to patient stratification and combination strategies

  Qingqing Li

  Frontiers in Medicine

  doi 10.3389/fmed.2026.1987146

• Original Research

  Published 9 October 2026

  The stiffness of three-dimensional biomimetic matrices regulates insulin secretion via the Piezo1 mechanosensitive ion channel

  Xi Chen · Zhen Wang · Jiahao Gu · Yan Xue · Yang Xu · Yan Huang · Dongzhi Wang

  Frontiers in Chemistry

  doi 10.3389/fchem.2026.1981529

• Original Research

  Published 9 October 2026

  Tumor-antigen-specific polyclonal antibodies suppress tumor growth and metastasis in heterogeneous solid tumors

  Carine Ciron · Ophélie Dauphouy · Pierre Morice · Pierre-Joseph Royer · Gwenaëlle Evanno · Juliette Rousse · Françoise Shneiker · Bernard Vanhove · Odile Duvaux · Firas Bassissi

  Frontiers in Oncology

  doi 10.3389/fonc.2026.1947593

• Review

  Published 9 October 2026

  Metabolic reprogramming and metabolic homeostasis in podocyte injury: novel mechanistic insights and natural product therapies

  Zhongjie Qu · Wenqing Ba · Meijing Tang · Wenze Jiang · Mengting Zhu · Keda Lu

  Frontiers in Cell and Developmental Biology

  doi 10.3389/fcell.2026.1978760

• Review

  Published 9 October 2026

  Unraveling hair graying: insights into melanocyte biology and the aging process

  Siang-Yu Chen · Hao-Jui Weng · Yu-Wen Yeh · Chung-Ping Liao

  Frontiers in Cell and Developmental Biology

  doi 10.3389/fcell.2026.1815236

• Original Research

  Published 9 October 2026

  A novel CAF-related gene signature for prognostic and immunotherapy response prediction in PDAC based on single-cell RNA-seq and bulk RNA-seq data

  Xuezhi Du · Zesheng Li · Yuwei Wang · Lei Han · Jinjin Sun · Weipeng Gong

  Frontiers in Pharmacology

  doi 10.3389/fphar.2026.1873756

• Original Research

  Published 9 October 2026

  Adverse reactions of immune checkpoint inhibitors combined with acetaminophen/non-steroidal anti-inflammatory drugs (NSAIDs): a pharmacovigilance analysis of drug–drug interactions

  Xiayang Ren · Lihui Xue · Yanfeng Wang · Jian Xiao

  Frontiers in Pharmacology

  doi 10.3389/fphar.2026.1833275

• Original Research

  Published 9 October 2026

  Histopathology-guided spatial transcriptomic analysis identifies an ECM-associated stromal pattern in lacrimal gland adenoid cystic carcinoma with complementary proteomic and functional analyses

  Rong Luan · Difei Zuo · Yeqing Wang · Meixia Jiang · Xun Liu · Limin Zhu · Tingting Lin

  Frontiers in Pharmacology

  doi 10.3389/fphar.2026.1949721

• Review

  Published 9 October 2026

  Metabolic-inflammatory heterogeneity in PCOS assisted reproduction: a compartmental susceptibility model

  Lin Yuying

  Frontiers in Endocrinology

  doi 10.3389/fendo.2026.1963493

• Original Research

  Published 8 October 2026

  Regulatory role and mechanism of sRNA24 targeting pqsH in Pseudomonas aeruginosa infection immunity

  Huanlan Liao · Qianying Liu · Yuyang Liu · Qiwei Li · Yujuan Xiong · Lan Wang · Yang Lu

  Frontiers in Cellular and Infection Microbiology

  doi 10.3389/fcimb.2026.1933779

• Mini Review

  Published 8 October 2026

  Metabolic rewiring at the obesity–estrogen–polyamine axis in endometrial cancer: emerging mechanisms and translational opportunities

  Daniel Simancas-Racines · Dolores Jima Gavilanes · Andri Matos · Gabriele Davide Bigoni-Ordóñez · Claudia Reytor-González

  Frontiers in Cell and Developmental Biology

  doi 10.3389/fcell.2026.1954981

• Systematic Review

  Published 8 October 2026

  Mapping the intellectual landscape of lactylation research: a bibliometric analysis of global trends and emerging frontiers

  Jieyan Wang · Zhou Li · Xiya Li · Xiyu Liu · Zhaohua Zhong · Yantong Wan · Hui Liang

  Frontiers in Pharmacology

  doi 10.3389/fphar.2026.1841236