Mini Review
Published
A proposed retinal venular immune gate: a mini review of perivascular macrophages and basement-membrane organization
Zhiqing Huang · Zijian Huang
Frontiers in Immunology
doi 10.3389/fimmu.2026.1970491
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 58 articles
Hypothesis and Theory
Published
A SynNotch-PiggyBac gene circuit for inflammation-responsive IL-10 delivery in Alzheimer’s disease: a hypothesis and design framework
Suhani Gupta · Ronav Gupta
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1866161
Original Research
Published
TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology
Zheng Liu · Yuchen Yu · Yu Wang · Shuohan Ning · Tongshuai Huang · Jingqi Li · Sihan Fan · Chaolong Lu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1920487
Hypothesis and Theory
Published
Immunometabolic synaptopathy: linking metabolic syndrome to epileptogenesis through trained immunity and parvalbumin interneuron vulnerability
Baihui Zhang · Wenjin Wang · Tao Li · Hua Huang
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1979155
Original Research
Published
Influenza A (H1N1)pdm infection exacerbates behavioral, cognitive, and synaptic impairments in 5xFAD mice
Anastasiya Rakovskaya · Alexey Lozhkov · Valeria Tverdokhlebova · Yana Zabrodskaya · Egor Vinokurov · Valeria Kirenskaya · Alexander Erofeev · Angelika Garshinina · Valeria Zryacheva · Anna Shtro · Ekaterina Pchitskaya · Olga Vlasova · Ekaterina Elpaeva · Pavel Dav · Ilya Bezprozvanny · Andrey Vasin
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1955816
Original Research
Published
Identification of microglia-associated hub genes and a CX3CR1/P2RY12 two-gene diagnostic model for cross-subtype epilepsy-associated cortical malformations: integrated transcriptomic analysis with external validation
Hongliang Zeng · Bin Li
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1954412
Review
Published
Microglia and immune signaling as architects of the brain
Anna Kim · Cynthia M. Solek · Edward S. Ruthazer
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1936860
Original Research
Published
Multi-cohort meta-analysis, single-cell and Mendelian randomization analyses with experimental validation identify RHBDF2 as a shared mediator of ulcerative colitis and blood–brain barrier disruption
Jiongjiong Cheng · Aman Xu
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1970578
Original Research
Published
Regional tau burden tracks with lower microglial HLA class II transcription in the human brain
Fan Li · Suqin Jin · Ping Wang · Hui Yang · Xianghua Zhuang · Feifei Feng · Peng Cheng
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1979981
Systematic Review
Published
Circulating and cerebrospinal fluid soluble TREM2 levels and risk of perioperative neurocognitive disorders in surgical patients: a systematic review and meta-analysis
Haotian Wu · Yujie Wang · Zhifeng Gao · Huan Zhang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1899745
Mini Review
Published
Astrocytes at the interface of peri-ictal breathing dysfunction and SUDEP
Isato Fukushi · Isamu Ozaki · Mieczyslaw Pokorski · Yasumasa Okada
Frontiers in Network Physiology
doi 10.3389/fnetp.2026.1955271
Mini Review
Published
The cochlear macrophage in presbycusis: inflammaging, neuroinflammation, and targets for therapeutic modulation
Reef K. Al-Asad · Judith S. Kempfle
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1930209
Original Research
Published
Electroacupuncture inhibits pyroptosis to improve motor function in an MPTP-induced mouse model of Parkinson’s disease
Yu-Chen Ying · Yi-Yue Dong · Guang-Yan Chen · Xi Wang · Qian Fan · Xi-Chen Wu · Yue-Lai Chen
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1968826
Original Research
Published
Coordinated cellular architecture reveals weakened cortical structure–behavior coupling in normal aging
Xiaoyi Zhan · Pengcheng Tan · Tirzah Tan · Chia-Chien Chen
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1932616
Original Research
Published
Transient synaptic refinement and glial adaptations after whisker denervation in adult mice
Sean Collier · Laxmi Iyer · Kimberly R. Byrnes · Emily Petrus
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1941129
Review
Published
MSC-derived extracellular vesicles for spinal cord injury: inflammatory microenvironment modulation, stage-dependent repair mechanisms, and translational challenges
Hang Yu · Yifan Liu · Shulong Yin · Haoyue Hu · Linquan Li · Taotao Zhu · Jie Liu · Sheng Liu · Chenxi Zhao · Shiqing Feng
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1960271
Correction
Published
Correction: Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations
Agnieszka Pawlak · Jakub Stefanowicz · Zofia Kotkowska · Agata Gabryelska · Marcin Sochal · Filip Napieraj · Magdalena Kotlicka-Antczak · Dominik Strzelecki
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.2007021
Perspective
Published
Neuroimmune phenotypes in brain aneurysms and neurodegenerative diseases
Francis J. Lauzier · David C. Lauzier
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1916561
Review
Published
New insight into Alzheimer’s disease: small molecule-Aβ in the brain transport and peripheral organ clearance
Tianci Ma · Yongyi Li · Yuting Ding · Shijie Liu · Chuanhao Gao · Xiang Li · Zhiqian Tong · Yan Lv
Frontiers in Aging
doi 10.3389/fragi.2026.1921485
Perspective
Published
Towards a nonlinear “neuroimmune gate-model”: beyond stellate ganglion block and vagus nerve stimulation
Lorenz Fischer · Hans-Georg Schaible
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1976225
Original Research
Published
Divergent cellular responses to sciatic nerve crush versus transection: bilateral MYCN induction and distinct DRG neuronal responses
Shilian Zhou · Ziyan Huang · Zhongyuan Lin · Jingwei Chen · Xinyu Zhang · Diya Wang · Haihua Shu · Fang Ye
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1922426
Original Research
Published
Refined protocol for quantifying hippocampal neurogenesis in organotypic slice cultures
Irem Akyel · Graham K. Sheridan
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11165
Review
Published
HSV-1 infections of the prefrontal cortex: regional vulnerability, cellular mechanisms, and neurocognitive consequences
Hannah Chau · Julia Schurr · Jonna M. Leyrer-Jackson · Erin S. Honsa
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1887935
Review
Published
Hyperbaric oxygen therapy in sepsis-associated encephalopathy: pathophysiological rationale, preclinical evidence, and translational challenges
Yikun Xie · Yihao Li · Yujing Li · Shuai Chen · Guanqi Song · Hongyu Wang
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1941147
Mini Review
Published
Time-resolved phenotyping of seizure evolution in developmental and epileptic encephalopathy: insights and gaps from the CYFIP2 Arg87Cys mouse model
Ruiying Ma · U Suk Kim · Yousun Chung · Kihoon Han
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1963161
Review
Published
Lysosomes as chemical and metabolic organizers of central nervous system injury and repair
Tengfei Zhao · Hanxu Huang · Yifan Wang · Yuliang Zhong · Zhiwei Zhong · Deting Xue · Wei Zhu · Kan Xu
Frontiers in Chemistry
doi 10.3389/fchem.2026.1891677
Original Research
Published
Protective effects of an aqueous extract from Pinctada fucata martensii mucus on ultraviolet A-induced skin photoaging: in vitro and in vivo evidence
Anqi Cao · Xiaohui Wang · Siwei Quan · Yingfa Qin · Wenjiang Cai · Junmin Quan
Frontiers in Natural Products
doi 10.3389/fntpr.2026.1961314
Review
Published
“Stand by me”: astrocyte–microglia crosstalk in central nervous system development, homeostasis, injury, and disease
Alberto Javier Ramos · Alejandro Villarreal
Frontiers in Network Physiology
doi 10.3389/fnetp.2026.1895622
Review
Published
Microglial handling of myelin debris and remyelination after ischaemic stroke: recognition, intracellular processing, lipid fate, and oligodendroglial repair
Mingrui Song · Nan Bu · Long Wei · Jing Chen
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1945478
Original Research
Published
ALDH1/2 deficiency modulates dieldrin-induced dopaminergic neurodegeneration and reactive glial morphometry in male mice
Omar A. Yanouri · Adam J. Schuller · Savannah M. Rocha · Aidan M. Briggs · Paul A. Martinez · Elizabeth Fernandez · Randy Strong · Xueshu Li · Hans-Joachim Lehmler · Jonathan A. Doorn · Ronald B. Tjalkens
Frontiers in Toxicology
doi 10.3389/ftox.2026.1888799
Review
Published
Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder
Kazuhiko Yamamuro · Takahira Yamauchi · Manabu Makinodan
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1915506
Review
Published
Periodontitis and Alzheimer's disease, common pathways in down syndrome
Fabio Arriola-Pacheco · Alicia Leonor Pinzón-Té · Rodrigo Serrano-Piña · Bertha Arelly Carrillo-Ávila · Jaime Díaz-Zúñiga · Samanta Melgar-Rodríguez · Víctor Manuel Martínez-Aguilar
Frontiers in Dental Medicine
doi 10.3389/fdmed.2026.1930049
Review
Published
Extracellular vesicle-integrated brain organoid-on-a-chip systems for neuroimmune communication and precision therapy in viral encephalitis
Md. M. N. Azim
Frontiers in Lab on a Chip Technologies
doi 10.3389/frlct.2026.1915723
Review
Published
The effects of abused drugs on ferroptosis pathways: potential therapeutic targets for substance use disorders
Tamara Bouchard · Brooke Russell · Liam Liyang Guo · Tina Nguyen · Yan Cheng · Yan Y. Sanders · Ming-Lei Guo
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1899553
Review
Published
Neuroinflammation in postoperative cognitive dysfunction: the multi-target potential of esketamine in modulating microglial responses and synaptic integrity
Hao-Tian Li · Guang-Yong Lin · Wen-Tao Xing · Yu Liu · Chuan-Xiang Zhang
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1868647
Mini Review
Published
Update on sex-specific microglia contribution to early synaptic dysfunction in Alzheimer’s disease
Candice M. Roux · Slavica Krantic
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1905780
Original Research
Published
Rotenone-induced oxidative stress triggers peroxisomal alterations in BV-2 microglial cells
Alessio Valenza · Maurizio Muzzi · Francesca Rendina · Irene Montali · Daniele Pensabene · Anna Fracassi · Marco Segatto · Sandra Moreno
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1941513
Review
Published
From metabolism to neurodegeneration: how microglial functional reprogramming drives neurodegenerative diseases
Qiaoqiao Cui · Ke Zheng · Qiyun Liu · Lizhen Wang · Yixin Liu · Ruifang Bai · Wei Zhang · Junhong Guo · Xueli Chang · Juan Wang
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1921079
Review
Published
Microglia-mediated neuroinflammation in Alzheimer’s disease: mechanisms and emerging therapeutic targets
Lianjing Xu · Ying Zhang · Li Jiang · Jin Feng Xing · Jing Hu · Tianye Lan · Guang Ta
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1902577
Hypothesis and Theory
Published
A minimal three-arm oral regimen for healthspan: mechanistic alignment with transcriptomic signals from a large parental-lifespan GWAS
Ngo Cheung
Frontiers in Aging
doi 10.3389/fragi.2026.1856979
Original Research
Published
Boldine treatment prevents chronic cognitive impairment and exaggerated fear learning in rats exposed to repetitive low-level blast injury
Georgina Perez Garcia · Gissel M. Perez · Rita De Gasperi · Miguel A. Gama Sosa · Serena Yeung · Carolyn W. Zhu · Patrick R. Hof · Jiangping Pan · Shahrukh Khalique · Alexey Kozlenkov · Wei Zhao · Carlos A. Toro · Gregory A. Elder · Christopher P. Cardozo
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1894226
Review
Published
The ERK MAPK pathway in mesenchymal glioblastoma: tumorigenesis, microenvironmental reprogramming, and the therapeutic promise of RAS(ON) multi-selective inhibition
Uma M. Basole · Mary M. Fitzpatric · Joseph Donohoe · Shashank Obulasetti · William Snider · Emily Haugen · Damir Garcia · Ana Gonzalez-Manteiga · Mathieu Sertorio · Marc Oria
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1857885
Mini Review
Published
Volume electron microscopy in axon regeneration research: insights into mitochondria, endoplasmic reticulum, and membrane contacts
Hiromi Tamada
Frontiers in Neural Circuits
doi 10.3389/fncir.2026.1870424
Review
Published
Advances in research on pharmacological mechanisms of anatabine: from nicotinic modulation to multitarget therapeutic potential
Xiaonan Li · Xiaomin Liu · Huaquan Sheng · Jianfeng Guo · Leihao Zhang · Ting Fei · Yihan Gao
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11069
Review
Published
Mechanistic insights into the synaptic damage-repair and regeneration processes in neurodegenerative Alzheimer’s disease: phytochemicals as neuroprotective agents
Bharti Yadav · Prabhakar Gangwar · Kirti Kumari · Anuradha Yadav · Rashmi Rao · Keshav Kumar · Harkomal Verma · Monisha Dhiman · Anil Kumar Mantha
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1835778
Original Research
Published
Selective enrichment of TCF4 in GABAergic neurons during postnatal primate development
Alain C. Burette · Rebecca I. Hipp · Sarah Salvador · Chavely Gonzalez Ramirez · Ridthi K. R. Patel · Naomi R. Salvador · Katherine A. Dasher · Jeff Bennett · David G. Amaral · Benjamin D. Philpot
Frontiers in Neuroanatomy
doi 10.3389/fnana.2026.1720211
Original Research
Published
Folic acid modulates the Notch1/NF-κB pathway in a rat model of lipopolysaccharide-activated hippocampal microglia
Marwa Abd El-kader · Eman A. E. Farrag · Randa El-Gamal · Eman Mohamed El Nashar · Areej M. Alshehri · Rashid A. Aldahhan · Khulood M. Al-khater · Sara El-Desouky · M. W. El-Sherbeni · Neven A. Ebrahim
Frontiers in Neuroanatomy
doi 10.3389/fnana.2026.1748518
Original Research
Published
A Physics Informed Neural Network (PINN) framework for fractional order modeling of Alzheimer's disease
Adnan Mehmood · Muhammad Farman · Farkhanda Afzal · Kottakkaran Sooppy Nisar · Mohammed Altaf Ahmed · Mohamed Hafez
Frontiers in Neuroinformatics
doi 10.3389/fninf.2026.1748481