Review
Published
Microbial-derived metabolites in cancer: evidence boundaries, immune mechanisms and translational pathways
Xuefeng Shi · Shunjun Wang · Wenhao Ouyang
Frontiers in Immunology
doi 10.3389/fimmu.2026.1947330
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 568 articles
Original Research
Published
Low-frequency passive mechanical stimulation produces antidepressant-like effects in rats involving gut–brain axis modulation
Rong Gao · Wenjing Pu · Yifei Lv · Liqiong Liu · Yan Zhao · Hao Liu · Li Chen · Nan Guan · Hongen Li
Frontiers in Immunology
doi 10.3389/fimmu.2026.1928978
Original Research
Published
Donor–recipient Hepatitis B serological patterns and post-transplant HBV events in pediatric living donor liver transplantation: a single-center retrospective cohort with a nested case series
Ying Le · Haifeng Tang · Quanhai Zhang · Jiajun Weng · Lianbin Huang · Xiaoke Dai · Mingman Zhang
Frontiers in Immunology
doi 10.3389/fimmu.2026.1977829
Original Research
Published
Early dynamics of eosinophils and the neutrophil-to-lymphocyte ratio are associated with severe immune-related adverse events during nivolumab therapy for metastatic renal cell carcinoma
Ondřej Fiala · Jan Králíček · Jindřich Kopecký · Michal Vočka · Tomas Buchler · Hana Študentová · Jana Obertová · Beáta Rondzíková · Martin Matějů · Dominik Šafčák · Matej Hrnčár · Peter Priester · Martina Spisarová · Anežka Zemánková · Radka Lohynská · Michaela Tkadlecová · Lucie Grmelová · Petr Stránský · Bohuslav Melichar · Patrik Palacka · Alexandr Poprach
Frontiers in Immunology
doi 10.3389/fimmu.2026.1944728
Brief Research Report
Published
Distinct spatial immune architectures in tumor and tumor-adjacent tissues of early-stage non-small cell lung cancer
Isabella Polic · Claudio Arrechedera · Jared K. Slone · Amanda Montoya · Emily Bontekoe · Peixin Jiang · Anika Patel · Tatiana V. Karpinets · Xiaogang Wu · Xingzhi Song · Qianyun Luo · Heladio Ibarguen · Auriole Tamegnon · Mei Jiang · Cara Haymaker · Annikka Weissferdt · Ara A. Vaporciyan · Lydia E. Kavraki · Tina Cascone · Ignacio Wistuba · Luisa Maren Solis Soto · John V. Heymach · Jianjun Zhang · Don L. Gibbons · Alexandre Reuben
Frontiers in Immunology
doi 10.3389/fimmu.2026.1981839
Review
Published
Ulvan, carrageenan, and fucoidan: comparative immunomodulatory mechanisms and future directions in major algal sulfated polysaccharides
Shuang Zhao · Zhangyi Xia · Jinlin Liu · Meijing Zhang · Maozi Lin · Guangmao Ding · Longchen Tang · Fang Su · Jingyi Sun · Chao Zhao
Frontiers in Immunology
doi 10.3389/fimmu.2026.1949951
Review
Published
CAR-T-cell therapy for autoimmune neurologic diseases
Yunhan Zhao · Yunyu Ding · Congfeng Tang · Zhengrong Wei · Yuqing Fan · Xianhui Hu · Jilong Yi
Frontiers in Immunology
doi 10.3389/fimmu.2026.1942249
Mini Review
Published
A proposed retinal venular immune gate: a mini review of perivascular macrophages and basement-membrane organization
Zhiqing Huang · Zijian Huang
Frontiers in Immunology
doi 10.3389/fimmu.2026.1970491
Review
Published
Chimeric antigen receptor-engineered cell therapy for asthma: advances in targeting type 2 inflammation and translational challenges
Yifei Niu · Chenyang Jian · Peize Liu · Mengwei Wu · Haoyuan Li · Xu Li · Lili Zhi
Frontiers in Immunology
doi 10.3389/fimmu.2026.1979396
Review
Published
Epigenetic rewiring of immunological memory in cancer: heterogeneity, mechanisms, and therapeutic vulnerabilities
Wenna Liu · Xiaole Pan · Yujia Zhao · Zhimei Li · Dan Wu · Ying Liang
Frontiers in Immunology
doi 10.3389/fimmu.2026.1890189
Review
Published
Progress in research on gut microbiota regulation of tumorigenesis, progression, and therapeutic response via inflammatory cytokines
Yan Liu · Dan Zang · Jun Chen
Frontiers in Immunology
doi 10.3389/fimmu.2026.1922678
Review
Published
Calcium-dependent conformational transitions and ligand binding regulation of C-reactive protein: a comprehensive review
Bin Cheng · Zhi-Xin Yao · Guo-Qiang Wu
Frontiers in Immunology
doi 10.3389/fimmu.2026.1963529
Mini Review
Published
T-cell metabolic reprogramming in systemic lupus erythematosus: linking intracellular metabolism to effector differentiation and senescent-like/exhausted-like states
Yi Zou · Zhichu Ren · Yuki Kudo · Michihito Kono
Frontiers in Immunology
doi 10.3389/fimmu.2026.1961063
Original Research
Published
Dried blood spot IP-10 as a biomarker of tuberculosis severity and treatment responses: results from a phase IIb trial of adjunctive acetylsalicylic acid and ibuprofen
Iselin Høgbakk Edlund · Noelia Alonso-Rodriguez · Chiara Sopegno · Judith Farrés · Nino Gogichadze · Lilibeth Arias · Kaori L Fonseca · Kennedy Otwombe · Ziyaad Waja · Tumelo Moloantoa · Natasha Pillay · Thabiso Seiphetlo · Neil Martinson · Cristina Vilaplana · Anne Ma Dyrhol-Riise
Frontiers in Immunology
doi 10.3389/fimmu.2026.1924239
Original Research
Published
Integrative single-cell and bulk transcriptomic analysis identifies monocyte/macrophage senescence-associated candidate genes in pulmonary arterial hypertension
Xiaojun Chen · Weibin Wu · Yilong Liu · Guili Lian · Qingquan Liu
Frontiers in Immunology
doi 10.3389/fimmu.2026.1938985
Original Research
Published
SCD1 inhibition promotes lipid peroxidation and enhances anti-PD-1 response in triple-negative breast cancer
Quentin Herrera Garfia · Aurélien Azam · Eric Bonneil · Laetitia Montero-Ruiz · Mohsen Momeni · Mohammad Farran · Robin Jehay · Nor Eddine Sounni
Frontiers in Immunology
doi 10.3389/fimmu.2026.1843935
Original Research
Published
Spatial analysis of placentae during congenital cytomegalovirus infection suggests distinct cellular profiles in immune and trophoblast cells: an exploratory study
Elise Sintim-Aboagye · Huy Quang Quach · Indrani Mukherjee · Will Sherman · Katelyn T. Nguyen · Neil Ferland · Sheila Farnan · Kamila Otrubova · Namisha Verma · Dawn Littlefield · Sohan Punia · Erica Johnson · Mark Blackstad · Mark R. Schleiss · Andrew P. Norgan · Clive M. Gray · Elizabeth Ann L. Enninga · Rana Chakraborty
Frontiers in Immunology
doi 10.3389/fimmu.2026.1885923
Review
Published
MicroRNA cargo of extracellular vesicles as mediators of immune dysregulation in pediatric immune thrombocytopenia: from pathogenetic drivers to biomarkers
Lucia Argenziano · Maria Maddalena Marrapodi · Giuseppe Di Feo · Oriana Di Domenico · Francesca Rossi · Alessandra Di Paola
Frontiers in Genetics
doi 10.3389/fgene.2026.1951187
Review
Published
Silencing without clearing: pharmacological modulation of the SASP in aging and disease
Lukas Fresser · Zofia Chrienova · Jan Gebrt · Patrik Oleksak · Kamil Kuca · Eugenie Nepovimova
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1911529
Review
Published
Flavonoids in cancer pharmacology: molecular mechanisms, tumor microenvironment regulation, and drug resistance
Zhengyuan Yu · Zhanyi Zhou · Ni Yin · Hongcheng Ge
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1969337
Review
Published
NEDD4-1: from molecular mechanisms to clinical translation in human diseases
Haifen Tian · Yongsheng Huang · Yun Liang · Chengjun Huang · Bingbing Wei · Chang-Neng Liao · Weijie Zhou
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1897001
Review
Published
Early life stress, lower urinary tract dysfunction, and respiratory disease: a proposed shared-mechanism framework
Tadanobu Chuyo Kamijo · Mayoko Tsuji
Frontiers in Physiology
doi 10.3389/fphys.2026.1929695
Review
Published
High-altitude gastric disorders: insights into maladaptation pathophysiological mechanisms, disease spectrum and prevention strategies
Huihui Shang · Rong Zhang · Youbang Xie · Airong Yang · Jing Wang
Frontiers in Physiology
doi 10.3389/fphys.2026.1944395
Original Research
Published
Whole-exome sequencing reveals cumulative rare variant burden associated with susceptibility to anti-tuberculosis drug-induced liver injury in a Han Chinese cohort
Yang Hao · Xiaoqing Zhang · Daiyun Huang · Shengyin Qin · Yunxiao Lin · Jianwen Ruan · Lu Shen · Na Zhang · Zhenting Wang · Cong Huai · Jianquan Zhang
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1952049
Correction
Published
Correction: Effect and mechanism of Emodin on mouse myeloid-derived suppressor cells
Frontiers Production Office
Frontiers in Pharmacology
doi 10.3389/fphar.2026.2001607
Mini Review
Published
From emergency myelopoiesis to trained immunity? Reframing post-stroke myeloid reprogramming along the brain-bone marrow axis
TongZhu Wei · YongJiu Wang
Frontiers in Neurology
doi 10.3389/fneur.2026.1976078
Review
Published
WRN helicase addiction in MSI-H colorectal cancer: biomarker-guided pharmacology, resistance evolution, and implications for other gastrointestinal cancers
Peng Zhang · Jiangsu Gan · Hongying Wang · Yali Xiong
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1962228
Original Research
Published
Perception of virus effects and vaccination among people with multiple sclerosis in Saudi Arabia
Hind Alnajashi · Khadijah Ibraheem Basheikh · Bushra Obaidallah A. Alqurayqiri · Fayzah Shaikh Albar · Shahad Ayed M. Algarni · Lana Saeed Allakhmi
Frontiers in Neurology
doi 10.3389/fneur.2026.1816182
Review
Published
Role of histone post-translational modifications in preeclampsia: from pathogenesis to diagnostic and therapeutic strategies
Yuanxuan Ma · Renwei Zhang · Mengting Yang · Jingli Wang · Bo Hou · Shiguo Liu
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1973542
Original Research
Published
Altered cytokine profiles and elevated lactate levels in children with autism spectrum disorder: indications of a dysregulated immune-metabolic network?
Nicole Beyer · Theresia Volk · Hella Luksch · Melanie Ring · Nora C. Vetter · Angela Roesen-Wolff · Min Ae Lee-Kirsch · Veit Roessner
Frontiers in Psychiatry
doi 10.3389/fpsyt.2026.1904470
Original Research
Published
TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology
Zheng Liu · Yuchen Yu · Yu Wang · Shuohan Ning · Tongshuai Huang · Jingqi Li · Sihan Fan · Chaolong Lu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1920487
Original Research
Published
Age-associated remodeling of NK cell subsets, B cell subsets, and T cell surface markers in peripheral blood of healthy Chinese adults: a prospective multicolor flow cytometry study
Liyuan Zheng · Wei Cao · Yixuan Wang · Tengda Xu · Fada Wang · Leidan Zhang · Xinchao Liu · Taisheng Li
Frontiers in Aging
doi 10.3389/fragi.2026.1847033
Hypothesis and Theory
Published
Immunometabolic synaptopathy: linking metabolic syndrome to epileptogenesis through trained immunity and parvalbumin interneuron vulnerability
Baihui Zhang · Wenjin Wang · Tao Li · Hua Huang
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1979155
Original Research
Published
Evaluation of large language models for ICI-related liver injury with an emerging microbiome focus
Man Sun · Dan Zang · Huan Zhou · Jun Chen
Frontiers in Cellular and Infection Microbiology
doi 10.3389/fcimb.2026.1955356
Review
Published
Strategies for the detection and prevention of human cytomegalovirus from pregnancy to the neonatal period
Pei Hu · Wenjie Chen · Ying Zhou · Mengyao Yu · Yuexinzi Jin · Xi Chen · Jiexin Zhang · Jin Zhou
Frontiers in Cellular and Infection Microbiology
doi 10.3389/fcimb.2026.1965954
Original Research
Published
Baseline SII and SIRI identify immune-inflammatory susceptibility and improve risk stratification of early subclinical cardiac dysfunction during non-steroidal aromatase inhibitor therapy
Cenyu Li · Zhengyu Tao · Yihan Wu · Chen Wu · Zi Wang · Xiaoning Wang · Huijuan Dai · Meng Jiang · Jun Pu
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2026.1888328
Original Research
Published
Clinical reasoning in canine meningoencephalitis of unknown origin and glioma: the role of signalment, history and neurological examination
Franziska Spohn · Samira Abani · Peter J. Dickinson · Karen M. Vernau · Christine M. Toedebusch · Kevin D. Woolard · Andreas Beineke · Holger A. Volk · Jasmin N. Nessler
Frontiers in Veterinary Science
doi 10.3389/fvets.2026.1920683
Original Research
Published
Laboratory-derived inflammatory–nutritional exploratory phenogroups and their associations with functional limitation and 30-day same-center all-cause unplanned readmission in patients with heart failure
Yilian Zhang · Xu Zhang · Hongbin Song · Qiyu Hu · Jingzhu Nan
Frontiers in Nutrition
doi 10.3389/fnut.2026.1985953
Mini Review
Published
Biomarker-guided immunotherapy in osteosarcoma: from immune microenvironment profiling to patient stratification and combination strategies
Qingqing Li
Frontiers in Medicine
doi 10.3389/fmed.2026.1987146
Original Research
Published
Clinical challenges in vaccine and monoclonal antibody development against ESCAPE pathogens: insights from EMA scientific advice procedures
Igor Stojkov · Linda Marchioro · Isabelle Bekeredjian-Ding · Benjamin Hofner
Frontiers in Medicine
doi 10.3389/fmed.2026.1931144
Case Report
Published
Durable partial response with low-dose, intermittent nivolumab in combination with gemcitabine for high PD-L1 metastatic triple-negative breast cancer: a case report
Po Lin Ooi · Jamin Munchar Elias · Francis Yew Fu Tieng
Frontiers in Oncology
doi 10.3389/fonc.2026.1964934
Original Research
Published
EQD2-adjusted mean lung dose and symptomatic pneumonitis after thoracic radiotherapy following immune checkpoint inhibitors in lung cancer: a single-center retrospective cohort study
Xiqing Li · Libin Liu · Nuo Zheng · Nila Wang · Tingxiong Xiao · Xiaolong Lin · Haidun Chen · Qin Shi · Yuyin Le
Frontiers in Oncology
doi 10.3389/fonc.2026.1923622
Review
Published
Progress on therapeutic mRNA vaccines for cancer
Siyu Wu · Huarong Liao · Wei Zhang
Frontiers in Oncology
doi 10.3389/fonc.2026.1980190
Review
Published
Plant endophytic fungi against plant-parasitic nematodes: from direct antagonism to plant-mediated biocontrol
María Lorena Giachero · Nathalie Marquez · Stephane Declerck
Frontiers in Plant Science
doi 10.3389/fpls.2026.2002520
Original Research
Published
Diverse Staphylococcus aureus lineages in a tertiary hospital in North Central Nigeria: emergence of CC1-ST772-MRSA, CC8-ST789-MRSA, and ST152-MRSA
Rasaki Adewole Raheem · Charles Nwabuisi · Abayomi Fadeyi · Bashirat Ayobola Olanipekun · Ademola Ibraheem Hamzat · Tomiwa Olumide Adesoji · Taofiq Adewale Sulayman · Alexander Mellmann · Frieder Schaumburg · Adebayo Osagie Shittu
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1908867
Original Research
Published
Single cell RNA-seq analysis identifies junctional adhesion molecule two positive endothelial cells aggravate osteoarthritis by mediating vascular permeability and macrophage adhesion
Yang Xing · Chengxin Li · Chao Wang · Linli Zheng · Puyi Sheng
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1937741
Review
Published
Metabolic reprogramming and metabolic homeostasis in podocyte injury: novel mechanistic insights and natural product therapies
Zhongjie Qu · Wenqing Ba · Meijing Tang · Wenze Jiang · Mengting Zhu · Keda Lu
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1978760
Original Research
Published
A novel CAF-related gene signature for prognostic and immunotherapy response prediction in PDAC based on single-cell RNA-seq and bulk RNA-seq data
Xuezhi Du · Zesheng Li · Yuwei Wang · Lei Han · Jinjin Sun · Weipeng Gong
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1873756