Editorial
Published
Editorial: Biosynthetic pathways and metabolic engineering of bioactive natural products from medicinal plants
Lihang Xie
Frontiers in Plant Science
doi 10.3389/fpls.2026.2003419
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Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 142 articles
Original Research
Published
Integrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
Jeany Söhnlein · Sascha Schäuble · Juan Prada Salcedo · Zahraa Abboud · Dalia Sheta · Kerstin Hünniger-Ast · Michelle Seif · Hermann Einsele · Thomas Dandekar · Gianni Panagiotou · Andreas Beilhack · Juergen Loeffler
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1922948
Original Research
Published
Natural polysaccharide-engineered POP@ZIF-67 nanoparticles coordinate antibacterial activity, macrophage polarization, and osteogenesis for chronic osteomyelitis therapy
Yunchang Zhao · Guangting Zhu · Mengxue Zhang · Yize Wu · Junwei Su · Jing Hu · Chao Jian · Ying Yuan
Frontiers in Bioengineering and Biotechnology
doi 10.3389/fbioe.2026.1935416
Original Research
Published
scTIME: single-cell-informed interpretable modeling of immunotherapy-associated immune states in non-small cell lung cancer
Guozhi Chen · Chenqiu You · Hong Gao · Chengjie Xu
Frontiers in Artificial Intelligence
doi 10.3389/frai.2026.1918104
Original Research
Published
Flow cytometric profiling of water buffalo milk EVs: how lactation stage drives phenotypic evolution and macrophage modulation
Barbara Canonico · Mariele Montanari · Ludovica Di Fabrizio · Giulia Franzoni · Giovanna De Matteis · Katia Cappelli · Francesco Grandoni · Maria Carmela Scatà · Daniele Lopez · Samanta Mecocci · Michela Battistelli · Tania Vanzolini · Giovanna Cappelli · Anna Donniacuo · Orlando Paciello · Caterina Ciacci · Stefano Papa · Michele Guescini · Paola Lanuti · Alessandra Martucciello
Frontiers in Veterinary Science
doi 10.3389/fvets.2026.1922591
Original Research
Published
LncRNA ZFPM2 silencing alleviates lung epithelial injury by inducing M2 macrophage polarization: possible implication in bronchopulmonary dysplasia
Hanzhou Guan · Huaiqing Yin
Frontiers in Pediatrics
doi 10.3389/fped.2026.1921479
Review
Published
Mesenchymal stromal cells in polytrauma: from immune dysregulation to therapeutic potential
Charles S. Black · Milen Kumar · Renato Miguel Reyes · J. Kent Leach · Mark A. Lee · Håvard Jostein Haugen · Thaqif El Khassawna · Maryam Rahmati · Augustine Mark Saiz
Frontiers in Bioengineering and Biotechnology
doi 10.3389/fbioe.2026.1892227
Original Research
Published
Integrating transcriptomic analysis to explore biomarkers and therapeutic targets for rheumatoid arthritis: a case-control and systems biology approach
S. Aswini · S. Mohamed Muzammil · N. Raja · S. Asha Devi
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1891543
Original Research
Published
FeNO may serve as a noninvasive screening tool for gastroesophageal reflux disease in children under 5 years: a retrospective study
Fang Wang · Ying Cheng · Xiaoqin Zhou · Junhua Shu · Lin Deng · Ruxin Zhang · Yi Gan · Zhongjian Wang
Frontiers in Pediatrics
doi 10.3389/fped.2026.1925154
Original Research
Published
Comparative nanotoxicity of polyethylene, silver, and copper oxide nanoparticles in African catfish (Clarias gariepinus): impacts on antioxidant defense, immunity, and tissue integrity
Mohammed Abdel-Wahab · Yousef A. Bin Jardan · Abdulaziz R. Alqahtani · Mohamed Abbas · Mohamed Hamed
Frontiers in Environmental Science
doi 10.3389/fenvs.2026.1855982
Original Research
Published
Design and optimization of mucoadhesive chitosan microspheres for oesophageal delivery of fluconazole
H. N. Shivakumar · Ayush Parmar · Rushikesh Shinde · Sanjana S. P
Frontiers in Drug Delivery
doi 10.3389/fddev.2026.1962873
Mini Review
Published
The cochlear macrophage in presbycusis: inflammaging, neuroinflammation, and targets for therapeutic modulation
Reef K. Al-Asad · Judith S. Kempfle
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1930209
Perspective
Published
Beyond the embryo: reframing recurrent implantation failure through immunopriming and endometrial immune dysregulation
Jayesh Amin
Frontiers in Reproductive Health
doi 10.3389/frph.2026.1892030
Review
Published
Cellular remodeling of lipedema affected subcutaneous adipose tissue
Sabrina Gohlke · Francisco Garcia-Carrizo · Robin Upmeyer · Tim J. Schulz
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1893552
Original Research
Published
Towards a holistic epidemiology of Streptococcus agalactiae using the BakRep repository
Linda Fenske · Oliver Schwengers · Alexander Goesmann
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1924154
Review
Published
MSC-derived extracellular vesicles for spinal cord injury: inflammatory microenvironment modulation, stage-dependent repair mechanisms, and translational challenges
Hang Yu · Yifan Liu · Shulong Yin · Haoyue Hu · Linquan Li · Taotao Zhu · Jie Liu · Sheng Liu · Chenxi Zhao · Shiqing Feng
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1960271
Original Research
Published
Integrated bulk and single-cell transcriptomic analyses with experimental validation identify PLOD1 as a diagnostic biomarker and TGF-β1-responsive profibrotic mediator in dupuytren’s disease
Xianjie Lin · Mingming Wang · Yutian Lin · Yinshen Zhu · Zhijiang Ye · Haoran Chen
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1924451
Perspective
Published
Neuroimmune phenotypes in brain aneurysms and neurodegenerative diseases
Francis J. Lauzier · David C. Lauzier
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1916561
Review
Published
Neu5Gc and beyond: sialylation at the innate immune and thromboinflammatory interface of xenotransplantation
Jae Young Kim
Frontiers in Transplantation
doi 10.3389/frtra.2026.1968710
Review
Published
Next-generation polymeric nanoparticles for regenerative endodontics: engineering the pulp microenvironment beyond antimicrobial therapy
Rosana Farjaminejad · Neeki Jabbari · Alexander Garcia-Godoy · Franklin Garcia-Godoy · Elnaz Tavazozadeh
Frontiers in Dental Medicine
doi 10.3389/fdmed.2026.1972546
Original Research
Published
Integrative bioinformatics screening of a M2 macrophage-associated gene signature for osimertinib resistance
Yajie Huang · Yaozhong Zhang · Jian Shi
Frontiers in Genetics
doi 10.3389/fgene.2026.1928986
Review
Published
CLDN18 and FGFR2 splicing variants are emerging tumor-associated antigens for cancer therapy
Masuko Katoh · Masaru Katoh
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1927389
Review
Published
Targeting gut dysbiosis: a new frontier in MASLD management
Shweta Sharma · Arun Pachauri · Harshal Nagar · Vishwa Thakkar · Kajal Patel
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1937809
Review
Published
Decellularized dental pulp extracellular matrix for pulp-dentin regeneration: a narrative review of processing, bioactivity, delivery, preclinical evidence, and translational challenges
Xinli Zhang · Mengjie Dong
Frontiers in Dental Medicine
doi 10.3389/fdmed.2026.1962311
Review
Published
Immunosuppressive cell populations as potential drivers of extrinsic immune checkpoint inhibition resistance in clear cell renal cell carcinoma
Usman Humayun Temuri
Oncology Reviews
doi 10.3389/or.2026.1953850
Original Research
Published
Effect of silymarin on Helicobacter pylori growth and adhesion: in vitro and in silico evaluation
Vitor Zorzal Majeski · Milena Lopes Francisco Bittencourt · Pedro Henrique Tregnago · Dalila Nickel Loose · Leonardo Bruno Federico · Rodrigo Rezende Kitagawa · Rita de Cássia Ribeiro Gonçalves
Frontiers in Natural Products
doi 10.3389/fntpr.2026.1890760
Original Research
Published
Symptom clusters and core symptoms in early postoperative esophageal cancer patients
Menglan Zhong · Changhong Wang · Xiaoqi Liu · Yan Wang · Xiaona Qi · Shaohua Xie
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1766306
Original Research
Published
A single-cell atlas and Shiny-based framework for murine lung injury and remodeling
Qiuming Wang · Jixian Li · Philip J. Moos · Alessandro Venosa
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1886929
Original Research
Published
Integrated AUF-UPLC-MS and fraction-activity correlation to identify COX-2-targeted constituents of Shaoyao Gancao decoction
Liping Li · Jun Chi · Hejia Wan · Yadi Hou · Bingjie Ren · Yixiao Li · Liping Dai
Frontiers in Chemistry
doi 10.3389/fchem.2026.1912431
Review
Published
Non-neoplastic histiocytic proliferations in bone marrow: a case series of uncommon morphologic findings
Melissa Ha · Shafagh Parsazad · Luke T. Dang · Elham Vali Betts · Denis M. Dwyre · Ananya Datta Mitra
Frontiers in Hematology
doi 10.3389/frhem.2026.1939019
Case Report
Published
Case Report: Multisystem response to dupilumab in a child with atopic dermatitis, asthma, eosinophilic esophagitis, and other gastrointestinal manifestations
Hua-Jie Yan · Wei Dong · Yu-Nan Yang · Chun-Yun Zeng
Frontiers in Allergy
doi 10.3389/falgy.2026.1929466
Systematic Review
Published
Research hotspots and emerging trends of macrophages in peripheral nerve injury: a bibliometric and visualization analysis
Guohua Jiang · Renkun Huang · Kewen Wang · Yuchang Gui · Yun Tang · Guiyang Jiang · Yijun Liu · Jianwen Xu
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1893849
Original Research
Published
Phytochemical characterization and evaluation of antimicrobial activity of Eugenia sp.: antibacterial, antibiofilm and ampicillin-potentiating activities against resistant Staphylococcus aureus and Staphylococcus epidermidis
Patryne Luana da Silva Dantas · Leticia Bachmann · Alysson Camilla Blaese Gramkov · Thaynara Reichert · Nicole Prada Zibell · Maressa Danielli Dolzan · Matheus Santos Lourenço · Saulo Relison Tintino · Tatiani Karini Rensi Botelho · Diogo Alexandre Siebert · Luciano Vitali · Cícera Datiane de Morais Oliveira-Tintino · Isabel Daufenback Machado · Michele Debiasi Alberton
Frontiers in Natural Products
doi 10.3389/fntpr.2026.1920078
Review
Published
Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder
Kazuhiko Yamamuro · Takahira Yamauchi · Manabu Makinodan
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1915506
Review
Published
Neuropeptide Y signaling in osteoarthritis pain: neuroimmune mechanisms, joint remodeling, and translational opportunities
Heng Qiu · Li Wang · Danni Luo · Yong Huang
Frontiers in Pain Research
doi 10.3389/fpain.2026.1884062
Review
Published
Multi-homosubunit dsRNA/dsDNA virus genome packaging nanomotors with sequential revolving mechanisms for potent drug development
Margaret Bohmer · Justin Gnarra · Daniel W. Binzel · Tao Weitao · Peixuan Guo
Frontiers in RNA Research
doi 10.3389/frnar.2026.1870177
Review
Published
Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential
Shuhan Yang · Siqian Wang · Ruiyi Yang · Ke Xu · Xiaofeng Yang · Yifeng Zhao
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1833678
Original Research
Published
Peripheral adaptive immune remodeling associated with severe hearing loss in older adults: a single-center flow-cytometry study with mouse cochlear transcriptomic context
Qunhui Zhang · Wei Liu · Meijun Shao · Jinyu Wang · Qianyi Zhong · Linlan Jiang
Frontiers in Aging
doi 10.3389/fragi.2026.1925166
Original Research
Published
Primary cell and tissue cultures of human choroid plexus epithelial cells
Ronja Bihlmaier · Melanie Scharr · Peter H. Neckel · Bernhard Hirt · Andreas F. Mack
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1827493
Mini Review
Published
Microgravity- induced organ and system-level deconditioning: a network physiology perspective
Rashmi Neginhal · Rebecca Rejo George
Frontiers in Network Physiology
doi 10.3389/fnetp.2026.1931834
Original Research
Published
Readiness of the in vitro alveolar macrophage assay: an interlaboratory comparison using 12 blinded particles
Emanoela Thá · Antje Vennemann · Vanessa Marani · Oliver Gräb · Andreas Verlohner · Lan Ma-Hock · Inka Marie Spyridonov · Pamina Weber · Aline Chary · Tommaso Serchi · Robert Landsiedel · Martin Wiemann
Frontiers in Toxicology
doi 10.3389/ftox.2026.1844090
Review
Published
Extracellular vesicles for abdominal aortic aneurysm: mechanisms, therapeutic potential, and translational challenges
Huibo Ma · Zongyou Xie · Yihang Cai · Fangda Li · Jianqiang Wu · Yuehong Zheng
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11246
Original Research
Published
Biodiversity and structure of livestock-associated bacteriophage communities in Brazil and Spain
Rafael Dorighello Cadamuro · Tatiany Aparecida Teixeira Soratto · Álvaro Cañete-Reyes · Glauber Wagner · Björn Andersson · Aline Viancelli · William Michelon · Paula Rogovski · David Rodríguez-Lázaro · Gislaine Fongaro
Frontiers in Water
doi 10.3389/frwa.2026.1881672
Review
Published
Echocardiography-guided fluid resuscitation in critical illness: from fluid responsiveness to fluid tolerance
Rachid Attou · Ayoub Jaafari · Sohaïb Mansour · Mohamed El Mallouli · Sébastien Redant · Andrea Gallerani · Hafid Khelifa
Frontiers in Anesthesiology
doi 10.3389/fanes.2026.1894770
Original Research
Published
Harnessing liposomal delivery to boost polyphenols’ potential in chronic wound therapy
Lisa Myrseth Hemmingsen · Marte Kristensen · Cecilie Thanh Loan Dang · Mari Salamonsen · Elizabeth G. Aarag Fredheim · Nataša Škalko-Basnet
Frontiers in Drug Delivery
doi 10.3389/fddev.2026.1839747
Case Report
Published
Spontaneous ventilation as rescue after failed one-lung ventilation in a patient with a destroyed lung and a TEF: a case report
Qiaomei Zhou · Haoxin Wang · Jianyan Chen
Frontiers in Anesthesiology
doi 10.3389/fanes.2026.1914653
Editorial
Published
Editorial: Targeting cancer metabolic reprogramming for cancer therapy
Werner J. Geldenhuys · Haitao M. Ji · Hoang V. Le
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1916506
Review
Published
The ERK MAPK pathway in mesenchymal glioblastoma: tumorigenesis, microenvironmental reprogramming, and the therapeutic promise of RAS(ON) multi-selective inhibition
Uma M. Basole · Mary M. Fitzpatric · Joseph Donohoe · Shashank Obulasetti · William Snider · Emily Haugen · Damir Garcia · Ana Gonzalez-Manteiga · Mathieu Sertorio · Marc Oria
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1857885