Original Research
Published
The impact of zeaxanthin and lycopene on fatty acid beta-oxidation in isolated peroxisomes from frozen livers of obese rats
Lina Baz · Mona Al-Thepyani
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1906904
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Showing 118 articles
Original Research
Published
Integrated bioinformatics and single-cell transcriptomics identify mitochondrial dysfunction-driven biomarkers for preeclampsia diagnosis
Lin Lin · Xiaowu Wang · Chengxiu Zhu · Kejun Ye · Dan Zhang · Ruohua Li · Mengjia Peng
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1922190
Original Research
Published
Symptom clusters and core symptoms in early postoperative esophageal cancer patients
Menglan Zhong · Changhong Wang · Xiaoqi Liu · Yan Wang · Xiaona Qi · Shaohua Xie
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1766306
Review
Published
GPCR signaling systems facilitate precision interventions for multi-oncology therapy
Ashley Del Pozo · Mia Pardo · Tabitha Boeringer · Carter J. Craig · Ramzia Sorathia · Madeline Millican · Stuart Maudsley
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1940022
Original Research
Published
Integrated microarray-based and single-cell transcriptomic analyses reveal cell adhesion-related fibrotic remodeling signatures in heart failure
Shun Zhang · Le Li · Zuohua Li · Xiaojun Wang · Juan Zhou · Qing Lyu
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1929610
Hypothesis and Theory
Published
The causal integration ladder: a multilevel evidence framework for therapeutic target evaluation in cervical cancer
Shishir Singh · Manyata Srivastava · Pragathi Uppada · Diksha Ameta · Aesha Singh · Monisha Banerjee · Atar Singh Kushwah
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1874355
Original Research
Published
Rational discovery of peptide inhibitors targeting Keap1: a focus on neurodegenerative diseases
Nandhini Senthilkumar · Shanthi Veerappapillai
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1929781
Original Research
Published
Electroacupuncture alleviates inflammatory pain by modulating the CXCL1/CXCR2 signaling axis in the spinal cord dorsal horn of rats
Xiazhen Xu · Ziyan Fang · Kaihua Song · Yang Shen · Chenxin Jiang · Mengchao Xu · Shouhai Hong
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1880288
Original Research
Published
Palmitoylation-related lncRNAs link molecular signaling, immune remodeling, and tumor progression in glioma: prognostic modeling and functional validation of LYRM4-AS1
Juan Xu · Chen Zhang · Lingling Pu · Xiaoyang Zhu · Xiaoan Sheng · Juanjuan Dong · Miaomiao Song · Chao Wang
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1901839
Original Research
Published
Causal effects of gut microbiota on functional gastrointestinal disorders: a bidirectional Mendelian randomization study
Yutong Cheng · Qiuai Shu · Ziwei Wang · Jian Wu · Yuxin Peng · Jiale Xie · Xiru Liang · Zhiwei Tao · Haitao Shi · Zhongcao Wei · Jinhai Wang · Ning Xie
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11023
Review
Published
Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder
Kazuhiko Yamamuro · Takahira Yamauchi · Manabu Makinodan
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1915506
Original Research
Published
In silico transcriptomic analysis nominates TSPAN32 as a central node of SCFA-driven immunometabolic reprogramming in intestinal epithelial cells
Zahra Masood · Iqra Sarwar · Ayesha Sanam · Amber Zaidi · Muhammad Zulfiqah Sadikan
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1847552
Original Research
Published
Revealing RELL1 signaling relying on the phosphoregulatory network analysis
Pathiyil Sajini Sekhar · Diya Sanjeev · Amal Fahma · Suhail Subair · Athira Perunally Gopalakrishnan · Prathik Basthikoppa Shivamurthy · Rajesh Raju · Sowmya Soman
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1939325
Review
Published
Sleep disturbances as an early indicator of psychotic disorders in adolescents and young adults
Julia Jaromirska · Dominik Strzelecki · Magdalena Kotlicka-Antczak · Piotr Białasiewicz · Agata Gabryelska
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1949833
Review
Published
KAT5: the epigenetic regulator of central nervous system diseases
Xiaoming Xin · Lingjuan Wu · Meichen Liu · Tian Liu · Zihan Yuan · Liang Zhang · Tongqing Duan · Lei Zhang · Xianmin Zhu
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1887674
Review
Published
Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential
Shuhan Yang · Siqian Wang · Ruiyi Yang · Ke Xu · Xiaofeng Yang · Yifeng Zhao
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1833678
Original Research
Published
Conformational dynamics of fuzzy interfaces in disordered protein complexes: mapping key residues and binding modes beyond NMR models
María Laura Fernández · María Clara Bastien · Franco G. Tavolaro · Cristina Marino-Buslje
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1907936
Review
Published
The effects of abused drugs on ferroptosis pathways: potential therapeutic targets for substance use disorders
Tamara Bouchard · Brooke Russell · Liam Liyang Guo · Tina Nguyen · Yan Cheng · Yan Y. Sanders · Ming-Lei Guo
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1899553
Review
Published
Lipid metabolic reprogramming in clear cell renal cell carcinoma: focus on high-density lipoprotein-related pathways
Lize Wu · Huaying Xue · Yifei Wu · Ningning Shen · Zhiqing Yang · Lifang Gao · Wenxia Ma · Chen Wang
Oncology Reviews
doi 10.3389/or.2026.1887460
Original Research
Published
Altered serum interleukin-4 and monocyte chemoattractant protein-3 levels are associated with generalized anxiety disorder: a case-control study
Most. Humayra Binta Rashid · Mehedi Islam · Sardar Mohammad Ashraful Islam · Md. Rabiul Islam
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11144
Mini Review
Published
Update on sex-specific microglia contribution to early synaptic dysfunction in Alzheimer’s disease
Candice M. Roux · Slavica Krantic
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1905780
Review
Published
Exposome influences: a multi-omics perspective on the combined toxic effects of pharmaceuticals and personal care products in Alzheimer’s disease
İ. İpek Boşgelmez · Beyza Mertaş · Hayrunnisa Deliser
Frontiers in Toxicology
doi 10.3389/ftox.2026.1871830
Review
Published
Microglia-mediated neuroinflammation in Alzheimer’s disease: mechanisms and emerging therapeutic targets
Lianjing Xu · Ying Zhang · Li Jiang · Jin Feng Xing · Jing Hu · Tianye Lan · Guang Ta
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1902577
Review
Published
The ERK MAPK pathway in mesenchymal glioblastoma: tumorigenesis, microenvironmental reprogramming, and the therapeutic promise of RAS(ON) multi-selective inhibition
Uma M. Basole · Mary M. Fitzpatric · Joseph Donohoe · Shashank Obulasetti · William Snider · Emily Haugen · Damir Garcia · Ana Gonzalez-Manteiga · Mathieu Sertorio · Marc Oria
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1857885
Original Research
Published
InfoMedex: drug-drug interaction prediction via a multimodal CNN-transformer model
Andrew Disharoon · Shifi Pasupuleti · Clark Thurston · Matt Fiore · Sadie McKenzie · Alysia Smith · Aaron J. Masino
Frontiers in Drug Safety and Regulation
doi 10.3389/fdsfr.2026.1841035
Review
Published
FcεRII (CD23) in dermatological disorders: structure, function, and clinical implications
Natalia Zdanowska · Wiktoria Nowik-Zając · Joanna Czerwińska · Joanna Najbar · Agnieszka Owczarczyk-Saczonek
Frontiers in Allergy
doi 10.3389/falgy.2026.1849342
Original Research
Published
Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer
Apoorva K. A. Pai · Leona Dcunha · Athira Perunelly Gopalakrishnan · Samseera Ummar · Athira C. Rajeev · Rajesh Raju
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1788470
Review
Published
Secreted proteins of Mycobacterium tuberculosis as therapeutic targets for drug discovery
Anthony Musaazi Kaweesa · Divya Tiwari
Frontiers in Tuberculosis
doi 10.3389/ftubr.2026.1736139
Mini Review
Published
Sex differences in memory impairments after traumatic brain injury: mechanisms and models
Isabella K. Robson · Clement Hamani
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1874990
Review
Published
Advancing the frontiers of ovarian cancer therapy: a comprehensive synthesis of emerging cell death paradigms
Xi Ye · Weiping Zhu · Xiaojie Sun · Fangqiumei Yu · Qinhong Shen · Yingao Zheng · Xuanxuan Hong · Le Yu · Hanwen Zhang · Xiangfeng Zhang · Liehong Wang
Oncology Reviews
doi 10.3389/or.2026.1850292
Review
Published
Functional genetic signatures of the gut microbiome in cardiometabolic diseases: mechanisms and translational opportunities
Martin Nganga Muigano
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1847345
Review
Published
Autophagy in ischemic stroke: pathophysiology, therapeutics, and challenges ahead
Tshibambe N. Tshimbombu · Arsene Daniel Nyalundja · Gates Mulume Iragi · Josué Aganze Mwambali · Samira Braimah Shardow · Melissa Ewurakua Amoako · Kyle E. Thurmann · Daniel I. Gonzalez · Paige Banyas · Judea Wiggins · Supreet Kaur
Frontiers in Stroke
doi 10.3389/fstro.2026.1769395
Brief Research Report
Published
Spatial transcriptomic analysis of kidney biopsies identifies activation of complement and SPP1 networks in Staphylococcus infection-associated glomerulonephritis
Spyros Karaiskos · Luis Santana-Quintero · Cherri Bott · Rahul Paul · Sergey V. Brodsky · Isabelle Ayoub · Samir V. Parikh · Brad H. Rovin · Tibor Nadasdy · Hira L. Nakhasi · Sreenivas Gannavaram · Anjali A. Satoskar
Frontiers in Nephrology
doi 10.3389/fneph.2026.1863912
Review
Published
Targeting glucocorticoid receptor signaling in platinum-resistant ovarian cancer: translational rationale and clinical advances following the ROSELLA trial
Wenxiang Wang · Zhanghuan Li · Junjie Zhao · Mengyuan Chang · Yafang Zhang · Xiangyi Shen · Junming Yue · John Schorge · Wenjing Zhang
Oncology Reviews
doi 10.3389/or.2026.1861081
Review
Published
Autophagy in thyroid cancer: stage-dependent switch, mutation-specific regulation, and therapeutic targeting
Lihua Fang · Chaowen Wu · Huimin Sun · Jie Ning
Oncology Reviews
doi 10.3389/or.2026.1873752
Original Research
Published
Transcriptomics-based identification of shared biomarkers across type 2 diabetes, mild cognitive impairment, and uric acid metabolism
Yan Liu · Dongmei Kang · Yuan Lei
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11060
Mini Review
Published
How do pro-inflammatory cytokines alter miRNA profiles in brain endothelial cells? Mechanisms, consequences, and therapeutic strategies for blood-brain barrier protection
Nahla Galal Metwally · Sara Mohamad · Iris Bruchhaus
Frontiers in Malaria
doi 10.3389/fmala.2026.1849845
Original Research
Published
Effectiveness and safety of dupilumab in moderate-to-severe atopic dermatitis: a 24- and 48-week cohort from Colombia
Jhon Bolaños-López · Carlos Bello · Luz. E. Pérez · Farley González · Sergio Londoño · Yuri Torres · Alejandra Toro
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1838972
Brief Research Report
Published
Echocardiography-guided assessment of mouse cardiac transplant rejection improves model reproducibility
Angela Clemens · Sara Alibrandi · Paolo Molinari · Johan Noble · Barbara Franchin · Miguel Fribourg · Paolo Cravedi · Nicholas Chun
Frontiers in Transplantation
doi 10.3389/frtra.2026.1840060
Review
Published
Nicotinamide adenine dinucleotide phosphate oxidase 4 in lung disease: a review of its biology and therapeutic potential
Yilin Wang · Tianru Ben · Jianjiang Fang · Zengpan Li · Jinhua Ding · Liyan Xu · Kai Lin · Li Jiang
Experimental Biology and Medicine
doi 10.3389/ebm.2026.10941
Review
Published
Role of angiotensin-converting enzyme in cognitive aging: evidence from preclinical and clinical studies
Joshua Smith · Prakashkumar Dobariya · Tanvi R. Kadam · Swati S. More
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1855021
Perspective
Published
Neuropathy predicts early renal impairment in diabetes mellitus—the almost forgotten historical evidence. In memoriam Professor Göran Sundkvist
Peter Kempler · Dóra Marietta Balogh · Viktor J. Horváth · Adrienn Menyhárt · Manfredi Rizzo · Solomon Tesfaye · Vincenza Spallone
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1875311
Original Research
Published
Acute myocardial infarction induces sex-specific, time-dependent remodeling of the gut microbiome and intestinal immune compartment in retired breeder C57BL/6N mice
Eszter Pal · Neda Omidi Arjenaki · Yao Lu · Jianguo Xia · Lorraine Chalifour
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1818652
Original Research
Published
Connexin 43 enhances liver metastatic ability of GIST cells in vivo
Takako Kihara · Jiayin Yuan · Takashi Yamasaki · Makoto Yoshida · Mizuka Ohkouchi · Yuka Nakaya-Hashikura · Neinei Kimura · Kanae Hyodo · Chisato Ohe · Seiichi Hirota
Pathology and Oncology Research
doi 10.3389/pore.2026.1612383
Opinion
Published
Suicidality as a potential risk and therapeutic target during widespread GLP-1 receptor agonists use: implications of inflammation
Milica M. Borovcanin · Ivica Petrovic
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1869086
Systematic Review
Published
Environmental epigenetic modifiers in neurodegenerative diseases: a systematic review of epigenomic mechanisms and therapeutic targets
Pranay Wal · Sunita Mishra · Debashish Pradhan · Ankita Wal · Debashis Purohit · Lalit Mohan Nainwal · Vivek Dhir · Amin Gasmi
Frontiers in Epigenetics and Epigenomics
doi 10.3389/freae.2026.1833533
Review
Published
GLP-1 and GLP-2 as intestinal reparative therapies in inflammatory bowel disease: mechanisms, translation, and clinical opportunity
Joseph J. Lee · Pratikiran Bajgain · Amy L. Lightner
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1790420
Mini Review
Published
Computational and multi-omics systems biology for precision microbiome therapeutics
Ahmed Dewan · Maria Teresa Mascellino
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1842701