Mini Review
Published
DYRK1A – a gene dose paradox
Ante Plećaš · Gillian Gough · Sandra Kunštek · Mirna Babić · Aoife Murray · Dean Nižetić · Ivan Alić
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1963992
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Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 211 articles
Mini Review
Published
Pan-cancer biomarkers of immune therapy resistance: mechanisms and clinical translation
Chao Wang · Dong Yang
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1895670
Review
Published
The 19S proteasome as a therapeutic target in hematologic malignancies
Idaly M. Olivas · Mayra A. Gonzalez-Henry · Saeedeh Darvishi · Evelyn M. Esparza · Anna M. Eiring
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1918833
Brief Research Report
Published
Transcriptomic insights into loperamide-induced gastric dysmotility: RNA-seq analysis of a mouse model
Chunggeon Lee · Seung-Ju Hwang · Young-Su Yang · Bokyung Kim · Dong-Seon Kim · Daeui Park · Chang-Woo Song · Chang-Gue Son
Frontiers in Physiology
doi 10.3389/fphys.2026.1924065
Original Research
Published
Reference-signature projection framework for exercise transcriptomic directionality based on the IAV-DI reference axis
Anli Zhou · Min Zhang · Cheng Zhang · Jianjun Guo · Min Zhang · Yan Zhang
Frontiers in Physiology
doi 10.3389/fphys.2026.1943015
Review
Published
FOXF1 and alveolar–vascular dysregulation in bronchopulmonary dysplasia–associated pulmonary hypertension
Xinyu Wang · Jun Han · Su Yang · Minghui Xiu · Zekun Yu
Frontiers in Physiology
doi 10.3389/fphys.2026.1910923
Original Research
Published
Time-course profiling of behavioral phenotypes and Ywhah/ERK signaling expression within the vestibular region of the brainstem during motion sickness habituation
Xue Yue · Chenxi Jia · Lihong Zhai · Jie Deng · Dongjun Yang · Zhanguo Jin
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1955920
Original Research
Published
Regional tau burden tracks with lower microglial HLA class II transcription in the human brain
Fan Li · Suqin Jin · Ping Wang · Hui Yang · Xianghua Zhuang · Feifei Feng · Peng Cheng
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1979981
Original Research
Published
Nicotine and tobacco smoke reshape neuronal signaling networks from a single-nucleus transcriptomic perspective
Jian Jiang · Anfu Hu · Yixiao Jin · Xia Li · Guo-Jun Zhou · Yi Shen · Chengyun Xu · Xing Ji · Ximei Wu · Hong-Juan Wang
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1953804
Original Research
Published
Transcriptomic analysis identifies candidate molecular mechanisms underlying SCF+G-CSF-reduced neuropathology in aged APP/PS1 mice
Afua Addo · Bin Li · Sasidhar Murikinati · Robert Gardner · Li-Ru Zhao
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1705436
Review
Published
Context-dependent oxytocin receptor signaling: from molecular architecture to transcript-level receptor engineering
Benjamin Jurek · Julia J. Winter · Daniel S. Quintana
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1938379
Brief Research Report
Published
Development and validation of a reverse transcription-insulated isothermal PCR assay for detection of caprine kobuvirus and its epidemiological and molecular characterization in China
Yang Su · Wangqing Banma · Guangfu Zhao · Qibing Gu · Falong Yang · Shenglin Li · Erzi Qubi · Kebu Munai · Musha Jili · Yutao Shi · Mingjing Gu · Yaoxuan Li · Junwen Wang · Kehamo Abi
Frontiers in Veterinary Science
doi 10.3389/fvets.2026.1915957
Original Research
Published
Gut microbiota disturbance disrupts osteonal organization and mechanical competence during postnatal cortical bone maturation in rabbits with local metabolic and transcriptional remodeling
Xiaopei Yang · Ziming Geng · Hongji Wang · Gongzi Zhang · Shicheng Luo · Binbin Liu · Yansen Wang · Shuwei Zhang · Lihai Zhang
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1937899
Original Research
Published
Interpretable machine learning prioritizes transcriptomic features associated with ferroptosis-mitochondrial permeability transition net activity states in cervical cancer
Huiying Zhang · Yidong Zhu · Weijie Shao · Kai Xu
Frontiers in Genetics
doi 10.3389/fgene.2026.1930345
Original Research
Published
High-throughput screening to identify inhibitors of the MTB CARD•RNA polymerase protein-protein interaction
Glory M. Velazquez · Jonathan Z. Sexton · Scott G. Franzblau · Gauri S. Shetye · Akil Hossain · George A. Garcia
Frontiers in Tuberculosis
doi 10.3389/ftubr.2026.1937953
Original Research
Published
tRNA regulatory ecosystem states shape tissue and circulating small-RNA landscapes in gastric cancer
Jie Liu · Yangyang Chen · Jiaqing Hu · Xujin Wei · Xiaoling Zheng
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1960697
Original Research
Published
Methylglyoxal hampers the angiogenic capacity of human retinal endothelial cells modifying cell transcriptome with the contribution of NRSF/REST
Marianna Aprile · Cecilia Nigro · Caterina Perfetto · Alessia Leone · Simona Cataldi · Antonella Nicolò · Mariagiovanna Tramontano · Antonella Desiderio · Francesco Beguinot · Valerio Costa · Claudia Miele · Alfredo Ciccodicola
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1762167
Original Research
Published
Stage-specific transcriptional atlas of goose satellite cells uncovers sex-biased molecular dynamics associated with embryonic skeletal muscle development
Cui Wang · Kai Shi · Yi Liu · Yongping Yang · Guitao Jiang · Chuang Li · Shufang Chen · Huiying Wang · Daqian He
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1957937
Original Research
Published
Longitudinal single-cell analysis identifies a chemotherapy-suppressed proliferative program associated with adverse prognosis in neuroblastoma
Aiguo Zhu · Jian Wang
Frontiers in Genetics
doi 10.3389/fgene.2026.1878093
Mini Review
Published
The cochlear macrophage in presbycusis: inflammaging, neuroinflammation, and targets for therapeutic modulation
Reef K. Al-Asad · Judith S. Kempfle
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1930209
Original Research
Published
Actin disruption is associated with altered YAP/TAZ-responsive transcription and reduced migration during palatal shelf elevation
Yang Bai · Jiarong Liu · Siqi Tang · Yuxin Zhang · Chang Liu · Fangchun Chen · Xiaoming Wang · Xiaoxiao Pang
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1962374
Brief Research Report
Published
Dynamic increases in p53 expression suppress human myoblast differentiation
Ingrid R. Aragon · Neha Patole · Ajay Vachanaram · Avram Liban · Colin Hogendorn · Ulas Ozkurede · Feng Feng · Darko Bosnakovski · Eric Batchelor · Julia C. Liu
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1844660
Review
Published
Engrailed-1 in eccrine sweat gland development and regeneration: from evolutionary innovation to therapeutic perspectives
Lei Zhang · Zizhen Zhang · Jiaqi Cheng · Junhong Zhao · Yanyi Xing · Xiang Liu · Lihong Peng · Sixun Wu · Haihong Li
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1917336
Original Research
Published
Dynamic phosphorylation of DGCR8 regulates embryonic stem cell differentiation and microprocessor function
Ka Weng Leong · Lawrence Mok · Karen Gu · Jonathan S. Oakhill · Mark M. W. Chong
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1918038
Brief Research Report
Published
Activating transcription factor 6 is involved in the beneficial effects of growth hormone-releasing hormone antagonists in the corneal endothelium
Md Matiur Rahman Sarker · Saikat Fakir · Madan Sigdel · Nektarios Barabutis
Frontiers in Ophthalmology
doi 10.3389/fopht.2026.1946815
Review
Published
Lipid droplet organized metabolic vulnerabilities in melanoma: from the MITF low state to ferroptosis sensitization
Mengzhen Chen · Yi Wu · Muxin Zhao
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1948743
Original Research
Published
Bioinformatic prediction, qCLASH, and AlphaFold3 reveal non-overlapping layers of the miR-214-3p–mRNA interactome
Jia Yao · Bingqiao Huang · Chenyu Chang · Ziqi Lin · Jinyue Lei · Weifeng Zhu · Mo Lisha · Tielong Xu
Frontiers in Genetics
doi 10.3389/fgene.2026.1924314
Original Research
Published
Cellular, chromatin-accessibility, and spatial contextualization of bulk transcriptional patterns linked to positive peritoneal cytology in endometrial cancer
Jiangang Huang · Binglai Luo · Zhiqing Hu · Shuping Lin · Jinyong Wang · Meiyan Lin
Frontiers in Genetics
doi 10.3389/fgene.2026.1924936
Review
Published
High-order chromatin structures mediated by phase separation in cell senescence
Wenjing Sun · Boxian Li · Zhaoyong Xu · Jing Wang · Jing Cao · Yangzhong Wang · Jiale Wang · Wenbo Gu · Pengjun Xu · Liang Wang · Wenyan Xie
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1896884
Review
Published
From chromatin to proteostasis: multilevel gene regulation in Mendelian diseases
Himanshu Goel · Gunjan Garg
Frontiers in Epigenetics and Epigenomics
doi 10.3389/freae.2026.1944086
Review
Published
CLDN18 and FGFR2 splicing variants are emerging tumor-associated antigens for cancer therapy
Masuko Katoh · Masaru Katoh
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1927389
Original Research
Published
Single-cell transcriptomic analysis identifies vascular smooth muscle cell transcriptional programs associated with human carotid plaque remodeling
Yi-Jie Lu · Xue-Guang Lin · Ting Wang · Fan-Xuan Huang · Ying Deng · Shuai Jiang · Jing Dong Tang · Bo Yu
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1950061
Review
Published
Epigenetic, chromatin-associated, and epitranscriptomic regulation in chronic pain: mechanisms and translational prospects
Jianan You · Lei Li
Frontiers in Genetics
doi 10.3389/fgene.2026.1904744
Review
Published
Lysosomes as chemical and metabolic organizers of central nervous system injury and repair
Tengfei Zhao · Hanxu Huang · Yifan Wang · Yuliang Zhong · Zhiwei Zhong · Deting Xue · Wei Zhu · Kan Xu
Frontiers in Chemistry
doi 10.3389/fchem.2026.1891677
Review
Published
GPCR signaling systems facilitate precision interventions for multi-oncology therapy
Ashley Del Pozo · Mia Pardo · Tabitha Boeringer · Carter J. Craig · Ramzia Sorathia · Madeline Millican · Stuart Maudsley
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1940022
Perspective
Published
Development of an application for colorectal cancer prediction using SDC2 and TFPI2 methylation: an opportunity for early and noninvasive diagnosis in Latin-America
Fernando Hernandez-Medina · Alejandro Cornejo · Andrea Orue
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1922606
Review
Published
Precision engineering of upstream open reading frames for translational regulation and crop improvement
Linjie Xu · Jiaojiao Ren · Jinjie Zhu
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1818972
Review
Published
Molecular strategies to enhance induced pluripotent stem cell reprogramming in buffalo (Bubalus bubalis)
Eduardo Baia de Souza · Kaiana Recchia · Naira Caroline Godoy Pieri · Nathalia Nogueira da Costa de Almeida · Moysés dos Santos Miranda · Fabiana Fernandes Bressan
Frontiers in Animal Science
doi 10.3389/fanim.2026.1886584
Original Research
Published
Cross-species gene expression analysis identifies a type I interferon-associated transcriptional signature in Tregs from atopic dermatitis
Naoya Kase · Hina Nakamura · Chizuru Nakakomi · Manami Shimakata · Mai Banno · Ryotaro Kanari · Yohsuke Harada
Journal of Cutaneous Immunology and Allergy
doi 10.3389/jcia.2026.17310
Review
Published
Circular RNAs: from transcriptional noise to engineered therapeutics
Aaron C. Chack · Chad V. Pecot
Frontiers in Epigenetics and Epigenomics
doi 10.3389/freae.2026.1894220
Original Research
Published
Protective effects of an aqueous extract from Pinctada fucata martensii mucus on ultraviolet A-induced skin photoaging: in vitro and in vivo evidence
Anqi Cao · Xiaohui Wang · Siwei Quan · Yingfa Qin · Wenjiang Cai · Junmin Quan
Frontiers in Natural Products
doi 10.3389/fntpr.2026.1961314
Original Research
Published
Sex-associated circadian signaling signatures in the lateral hypothalamus
Sara K. Pintwala · Patrick M. Fuller
Frontiers in Sleep
doi 10.3389/frsle.2026.1895831
Original Research
Published
The role of goat FTO/IGF2BP1-mediated BCL11A m6A modification in intramuscular adipocyte differentiation
Wuqie QuBi · Yong Wang · Xin Li · Kehan Liu · Fangjun Lin · Yanyan Li · Jiani Xing · Youli Wang · Haitao Shi · Jiangjiang Zhu · Yaqiu Lin
Frontiers in Animal Science
doi 10.3389/fanim.2026.1875964
Brief Research Report
Published
SST interneuron maturation extends beyond the second postnatal week and is driven by coordinated transcriptional and functional remodeling
Ourania Christodoulou · Konstantinos Diskos · Angeliki Velli · Panagiotis Moulos · Kyriaki Sidiropoulou · Myrto Denaxa
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1892850
Brief Research Report
Published
R2Tg retrotransposon mediated targeted integration of exogenous genes into the 28S rDNA locus in mammalian cell lines for PKU gene therapy
Xiuyuan Wang · Ziqi Wen · Rongjun Xu · Wenjing Shi · Yiling Long · Xingri Zhan · Rui Su · Jia Fei · Yumin Li
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1893815
Original Research
Published
A multi-residue electrostatic clamp in HIV-1 CRF01_AE Tat underlies high-affinity engagement with NMDA and hDAT receptors
Shaughn Dominic M. Padon · Ana Joy P. Lozano
Frontiers in Tropical Diseases
doi 10.3389/fitd.2026.1923721
Original Research
Published
Deciphering the impact of genetic variants on vulnerability to Opioid Use Disorder
Rajashree Chakraborty · Chittibabu Guda · Avinash Veerappa
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1814602
Original Research
Published
Rapid subtype-specific detection of respiratory syncytial virus A and B using an RNase HII-dependent RT-LAMP lateral flow assay
Woong Sik Jang · Eunji Lee · Sun-Young Ko · Chae Seung Lim
Frontiers in Chemistry
doi 10.3389/fchem.2026.1942908