Articles

Showing 190 articles

• Study Protocol

  Published 30 July 2026

  Efficacy and safety of the traditional Chinese medicine formulation BL-1 for the treatment of low anterior resection syndrome: study protocol for a double-blind, randomized, placebo-controlled trial

  Jun Zhao · Jianxia Dong · Yu Zhang · Shi-Yu Tang · Qing Li · Qiangqi Cai · Xuemei Zhang · Lie Yang · Lin Zhu

  Frontiers in Gastroenterology

  doi 10.3389/fgstr.2026.1767318

• Review

  Published 29 July 2026

  Bioactive constituents of Hericium erinaceus: extraction strategies, health benefits and food applications

  Vibhuti Gurung · Narashans Alok Sagar · Nitu Rani

  Frontiers in Natural Products

  doi 10.3389/fntpr.2026.1872464

• Perspective

  Published 28 July 2026

  Redefining the geography of pharmaceutical innovation: Kelly Chibale as a harbinger for integrated drug discovery in Africa

  Fidele Ntie-Kang · Peter Mubanga Cheuka · Richard Kwamla Amewu · Elizabeth V. M. Kigondu · Collen Masimirembwa

  Frontiers in Drug Discovery

  doi 10.3389/fddsv.2026.1884834

• Review

  Published 23 July 2026

  The new era of MASH pharmacotherapy: a comprehensive review of FDA-approved and emerging agents

  Abeer Qasim · Rayan Alataa · Fnu Veena · Elona Shehi

  Frontiers in Gastroenterology

  doi 10.3389/fgstr.2026.1850915

• Clinical Trial

  Published 23 July 2026

  Comparing visual outcomes in matched patients receiving a low cylinder power toric IOL or a non-toric IOL

  Kjell G. Gundersen · Richard Potvin · Steffen A. Østenstad

  Frontiers in Ophthalmology

  doi 10.3389/fopht.2026.1755069

• Original Research

  Published 21 July 2026

  Assessment of compliance and satisfaction with a self-adjusting bimodal neuromodulation device and virtual follow-up visits used for tinnitus

  Grace Conchas · Yezihalem Mesfin · Yuan He · Abigail P. Heiller · Hubert H. Lim · Meredith E. Adams · Peggy Nelson

  Frontiers in Audiology and Otology

  doi 10.3389/fauot.2026.1789957

• Review

  Published 16 July 2026

  The molecular pathways of polyphenols in combating multidrug-resistant microbial superbugs: a comprehensive mechanistic review

  Michael T. Bayode · Shina Oguntuase · Joseph Chimezie · Ayomide Okiti · Esther Oyedeji · Isaac Ajayi · Jeremiah Adesanya

  Frontiers in Natural Products

  doi 10.3389/fntpr.2026.1879559

• Original Research

  Published 16 July 2026

  Extensive-stage small cell lung cancer in Hungary: a real-world analysis (2013–2022)

  Krisztina Bogos · András Bajcsay · Gabriella Gálffy · Lilla Tamási · Zsolt Pápai-Székely · Veronika Sárosi · Anikó Maráz · Regina Pálföldi · Lilla Horváth · Judit Hoffer · Szilvia Szécsényi · Kata Kirschner · Celia Blasszauer · Dániel Reibl · Ida Komka · Anna A. Ascsillán · Lajos V. Kemény · Gyula Ostoros

  Pathology and Oncology Research

  doi 10.3389/pore.2026.1612491

• Original Research

  Published 16 July 2026

  Transspinal stimulation preceding step training reorganizes spinal locomotor circuits in human spinal cord injury: a randomized sham-controlled clinical trial

  Timothy S. Pulverenti · Abdullah M. Sayed Ahmad · Noam Y. Harel · Maria Knikou

  Frontiers in Neural Circuits

  doi 10.3389/fncir.2026.1876368

• Review

  Published 15 July 2026

  PSMA-targeted radioligand therapy in advanced prostate cancer: a narrative review of ^177Lu-PSMA, emerging ^225Ac-PSMA strategies, and therapeutic sequencing

  Natalia Gierulska · Nina Jankowska · Adrianna Kwiatkowska · Piotr Kuchno · Kinga Łysak · Katarzyna Szklener · Kamil Kośmider · Magdalena Skórzewska

  Oncology Reviews

  doi 10.3389/or.2026.1834484

• Review

  Published 15 July 2026

  Recurrent retroperitoneal sarcoma: beyond resectability toward a biology-based therapeutic framework

  Dorian Yarih Garcia-Ortega · Montiel Jiménez Fuertes · Sergio Damian Quildrian · Nicolas A. Devaud · Javier Martin-Broto

  Oncology Reviews

  doi 10.3389/or.2026.1846525

• Original Research

  Published 15 July 2026

  Shotgun metagenomic analysis reveals taxonomic and functional alterations in the gut microbiome across prodromal and symptomatic Lewy body disease

  Xiaowei Zhao · Stuart J. McCarter · Vinod K. Gupta · Kiera M. Grant · Erik K. St. Louis · Kejal Kantarci · Rodolfo Savica · Max Hill · Helen E. Vuong · Christopher Staley · Bradley F. Boeve · Owen A. Ross · Levi M. Teigen · Jaeyun Sung

  Frontiers in Microbiomes

  doi 10.3389/frmbi.2026.1834726

• Case Report

  Published 15 July 2026

  Case Report: Alternative biopsy targets plus CEUS-guided omental puncture: enabling CLDN18.2 detection and precision therapy enrollment in pancreatic cancer

  Hang Yin · Xiaomeng Zhang · Bing Song · Hui Li · Kun Liu · Chengzheng Zhang

  Frontiers in Radiology

  doi 10.3389/fradi.2026.1800543

• Systematic Review

  Published 15 July 2026

  Global research landscape and trends of metabolomics in diabetic kidney disease: focus on immunometabolic interactions

  Yuting Li · Changlin Li · Jiamin Duan · Qingli Yang · Jing Zhang · Duo Yu · Yuwei Chen · Jianing Ni · Xiaomeng Lin · Xudong Cai

  Frontiers in Clinical Diabetes and Healthcare

  doi 10.3389/fcdhc.2026.1791774

• Systematic Review

  Published 10 July 2026

  Safety profile of small interfering RNA therapeutics: a systematic review and meta-analysis of randomized controlled trials

  Cheewon Ahn · Hyunsuk Jeong · Hyeon Woo Yim · Na Jin Kim · Sungpil Han · Ilhoan Oh

  Frontiers in Drug Safety and Regulation

  doi 10.3389/fdsfr.2026.1855572

• Review

  Published 9 July 2026

  Targeting glucocorticoid receptor signaling in platinum-resistant ovarian cancer: translational rationale and clinical advances following the ROSELLA trial

  Wenxiang Wang · Zhanghuan Li · Junjie Zhao · Mengyuan Chang · Yafang Zhang · Xiangyi Shen · Junming Yue · John Schorge · Wenjing Zhang

  Oncology Reviews

  doi 10.3389/or.2026.1861081

• Review

  Published 9 July 2026

  Navigating a new era in cardiovascular disease epidemiology: big data, artificial intelligence and the imperative of disability inclusion

  Theophilus I. Emeto

  Frontiers in Epidemiology

  doi 10.3389/fepid.2026.1871078

• Frontiers in Science Viewpoint

  Published 25 June 2026

  Treg therapy needs better trials

  Fadi Issa · Kathryn Wood

  Frontiers in Science

  doi 10.3389/fsci.2026.1874873

• Review

  Published 23 June 2026

  Impact of plant-based interventions on gynecological cancers: a narrative review of mechanistic interplays and clinical evidence

  Fidelis Batale Fabrael · John Sotunsa · Kehinde Samuel Olaniyi · Onome Bright Oghenetega · Oluwatobi Adewale · Blessing Monica Akindele · Faith Olanrewaju · Nekabari Lekpa Gbimadee · Seyi Olayemi · Abosede Oreoluwa Bolaji · Marvellous Osewe Iyobhebhe · Emmanuel Mololuwa Adegbotoluwa · Emmanuel Damilare Folahanmi · John Ahmadu Kaisar · Precious Adeoye Oyedokun

  Frontiers in Molecular Medicine

  doi 10.3389/fmmed.2026.1832188

• Case Report

  Published 23 June 2026

  Time-restricted eating in adults with type 2 diabetes mellitus on concomitant glucagon-like peptide-1 receptor agonists: case report

  Kyla L. Laing · Jordan L. Levy · Michael J. Wilkinson · Shweta Varshney · Satchidananda Panda · Pam R. Taub · Emily N. C. Manoogian

  Frontiers in Clinical Diabetes and Healthcare

  doi 10.3389/fcdhc.2026.1725278

• Original Research

  Published 19 June 2026

  Efficacy assessment in trials of complex and rare diseases: a comparison between the meta-analytic global statistical test and co-primary analysis

  Samuel P. Dickson · Abe Durrant · Caleb W. Dayley · Joshua R. Christensen · Craig H. Mallinckrodt · Suzanne B. Hendrix

  Frontiers in Medical Technology

  doi 10.3389/fmedt.2026.1819463

• Original Research

  Published 17 June 2026

  Good nights sleep program: design and preliminary findings from a randomized clinical trial to improve child and parent sleep in low-income families

  Brian T. Gillis · Ben Hinnant · Olivia Martín-Piñón · Elise L. Neuhoff

  Frontiers in Sleep

  doi 10.3389/frsle.2026.1764378

• Methods

  Published 16 June 2026

  Improving access to therapeutic clinical trials: a randomized controlled trial of GUIDE navigation and reimbursement

  Kristine A. Karvonen · Jean A. McDougall · Elizabeth A. Carosso · Tina Burrows · Solange H. Mecham · Chongzhi Di · Sarah D. Hohl · Elizabeth Stohr · Anne Devine · Hannah Linden · Ajay K. Gopal · Evan Y. Yu · Andrew J. Cowan · Jason A. Mendoza

  Frontiers in Cancer Control and Society

  doi 10.3389/fcacs.2026.1794900

• Review

  Published 12 June 2026

  Cardio-oncology in multidisciplinary synergy: addressing the rising burden of cancer therapy-related cardiovascular toxicity (CTR-CVT) in advancing oncology practices

  Putri Dwi Astuti · Eko Adhi Pangarsa · Andreas Arie Setiawan · Daniel Rizky · Budi Setiawan · Charles Limantoro · Damai Santosa · Catharina Suharti

  Oncology Reviews

  doi 10.3389/or.2026.1852886

• Original Research

  Published 11 June 2026

  An exploration of markers of microvascular dysfunction in kidney transplant recipients randomized to belatacept: no clinical impact of CNIs on endothelial function

  Edwin O. W. Bredewold · Rudmer J. Postma · Joe Chan · My H. S. Svensson · Annette Bruchfeld · Johannes W. de Fijter · Hans Furuland · Anders Hartmann · Lars Mjornstedt · Karin Skov · Inga soveri · Soeren S. Sorensen · Bengt Fellstrom · Jacques M. Duijs · Roel Bijkerk · Joris I. Rotmans · Anton-Jan van Zonneveld

  Frontiers in Transplantation

  doi 10.3389/frtra.2026.1812847

• Review

  Published 8 June 2026

  Pancreatic tissue engineering: towards a vascularized bioengineered cure for diabetes

  Ji Ho Park · Khadijat A. Olawuyi · Neekita R. Jikaria · Jazzmyn S. Dawes · Ishak E. Dabsha · André A. Dick · Dino J. Ravnic

  Frontiers in Transplantation

  doi 10.3389/frtra.2026.1768497

• Original Research

  Published 8 June 2026

  Interplay between CARD9 genetic variants and fungal colonization patterns among patients with diabetes

  Aiah M. Khateb · Rahaf Ghazi Alharbi · Lujain Alsweed · Mohammed Doud · Khlood F. Almuzaini · Abdulwahab Alzahrani · Sultan Fallatah · Muhammad Yasir · Esam I. Azhar

  Frontiers in Fungal Biology

  doi 10.3389/ffunb.2026.1825667

• Review

  Published 5 June 2026

  Integrative perspectives on electroacupuncture modulation of vagal–cholinergic and neuro–immune–metabolic regulation in long COVID

  Liwen Wang · Xiaoyang Hu · Dongning Yan

  Frontiers in Integrative Neuroscience

  doi 10.3389/fnint.2026.1775007

• Original Research

  Published 4 June 2026

  Detection and characterization of functional (side-)effects of diphenhydramine in the central nervous system using a neuro-behavioral assay: proof of concept

  Günther K. H. Zupanc · Hyeseo Hong

  Frontiers in Drug Discovery

  doi 10.3389/fddsv.2026.1833888

• Perspective

  Published 1 June 2026

  The fourth controlled release society workshop on oral peptide administration

  David J. Brayden · Stephen T. Buckley · Andrew L. Lewis

  Frontiers in Drug Delivery

  doi 10.3389/fddev.2026.1860678

• Community Case Study

  Published 29 May 2026

  Strengthening pharmacovigilance and regulatory capacity in Southern Africa (SPaRCS): achievements, experiences and lessons learned from a participatory action learning project

  Michelle Viljoen · Star Khoza · Mukesh Dheda · Libert Chirinda · Frieda Shigwedha · Anna Shimbulu · SipheSihle Nhlabatsi · Nomsa Shongwe · Albert Figueras · Raffaella Ravinetto · Hazel Bradley

  Frontiers in Drug Safety and Regulation

  doi 10.3389/fdsfr.2026.1765077

• Study Protocol

  Published 25 May 2026

  A multilevel CPAP support strategy implemented within a large stroke clinical trial (sleep SMART)

  Devin L. Brown · Jeffrey S. Durmer · Mark Aloia · Rebecca M. Hankla · Kayla Novitski · Joelle B. Sickler · Shannon Considine · Emerson Delacroix · Jason C. Ong · Alp Sinan Baran · Craig S. Anderson · Dawn M. Bravata · H. Klar Yaggi · Valerie Durkalski-Mauldin · Ronald D. Chervin

  Frontiers in Sleep

  doi 10.3389/frsle.2026.1832143

• Review

  Published 18 May 2026

  Pathogenesis of diabetic cardiomyopathy and emerging therapeutic strategies: a network-based perspective

  Haoqing Ren · Hengli Lai

  Frontiers in Clinical Diabetes and Healthcare

  doi 10.3389/fcdhc.2026.1823872

• Original Research

  Published 7 May 2026

  Global pharmacovigilance reporting: comparative analysis of adverse event obligations across five major regulatory authorities

  Carlos G. Bernaus · Maria Lilia Bournissen

  Frontiers in Drug Safety and Regulation

  doi 10.3389/fdsfr.2026.1821686

• Original Research

  Published 4 May 2026

  Optimisation of patient-reported outcome measurement for haematological cancer patients receiving novel immunotherapies: perspectives of multi-stakeholders

  Eilidh M Duncan · Jhulia Salviano · Charalampia Kyriakou · Samantha Nier · Simone Oerlemans · Sam Salek · Kate Morgan · Katie Joyner

  Frontiers in Hematology

  doi 10.3389/frhem.2026.1800304

• Case Report

  Published 4 May 2026

  Case Report: The molecular profile of granular cell astrocytoma predicts aggressive clinical behavior, independent of morphology

  Melanie Jensen · Pranoy Das · Oliver Wroe-Wright · Oscar MacCormac · Francesco Marchi · Ali Elhag · Yasir A. Chowdhury · Ross Laxton · Rebecca Ellmers · Omar Al-Salihi · Keyoumars Ashkan · Ranjeev Bhangoo · Francesco Vergani · Istvan Bodi · Zita Reisz · Jose Pedro Lavrador

  Pathology and Oncology Research

  doi 10.3389/pore.2026.1612388

• Review

  Published 1 May 2026

  Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions

  Yuexin Wu · Cuiying Zhang · Yangyang Peng · Longlong Liu

  Experimental Biology and Medicine

  doi 10.3389/ebm.2026.10997

• Systematic Review

  Published 29 April 2026

  Rebound regrowth phenomenon in patients with pediatric low-grade gliomas treated with MAPK inhibitors – a systematic review

  Malgorzata Styczewska · Weronika Lyzinska · Malgorzata A. Krawczyk · Ewa Bien

  Oncology Reviews

  doi 10.3389/or.2026.1815932

• Perspective

  Published 28 April 2026

  The role of nasal patency in obstructive sleep apnea: an expert consensus

  Andrew M. Vahabzadeh-Hagh · Patrick J. Strollo · Masayoshi Takashima · Kathleen Yaremchuk · Thomas Heineman · Ofer Jacobowitz · Yi Cai · Jolie Chang · Maria Suurna · Carol Yan · Atul Malhotra

  Frontiers in Sleep

  doi 10.3389/frsle.2026.1819496

• Review

  Published 20 April 2026

  Medicinal mushrooms and the hallmarks of cancer: mechanistic insights for complementary chemotherapy

  Eshed Haklai

  Frontiers in Cancer Control and Society

  doi 10.3389/fcacs.2026.1774081

• Mini Review

  Published 15 April 2026

  CAR T cell engineering approaches to minimise toxicities

  Elizabeth Hogben · Anna Schurich · Charlotte Graham

  Experimental Biology and Medicine

  doi 10.3389/ebm.2026.11021

• Clinical Trial

  Published 13 April 2026

  Comparison of primary and secondary stroke outcomes between government and private healthcare institutions: insights from the SPRINT India trial

  Shweta Jain Verma · Bhavya Nanda · Paramdeep Kaur · Arya Devi K. S. · Deepti Arora · Aneesh Dhasan · P. N. Sylaja · Dheeraj Khurana · Vijaya Pamidimukkala · Biman Kanti Ray · Vivek Nambiar · Sanjith Aaron · Gaurav Mittal · Aparna R. Pai · Sankar Prasad Gorthi · Somasundaram Kumaravelu · Yerasu Muralidhar Reddy · Sunil Narayan · Nomal Chandra Borah · Rupjyoti Das · Girish Baburao Kulkarni · Vikram Huded · Thomas Mathew · Rohit Bhatia · Pawan Kumar Ojha · Jayanta Roy · Anand Girish Vaishnav · Arvind Sharma · Abhishek Pathak · Sanjeev Kumar Bhoi · Sudhir Sharma · Sulena Sulena · Aralikatte Onkarappa Saroja · Neetu Ramrakhiani · Madhusudhan Byadarahalli Kempegowda · Mahesh Kate · Tina George · Ivy Sebastian · Meenakshi Sharma · Rupinder Dhaliwal · Jeyaraj D. Pandian

  Frontiers in Stroke

  doi 10.3389/fstro.2026.1805422

• Original Research

  Published 8 April 2026

  Simultaneous measurement of 16S-rRNA and pre-16S-rRNA as a strategy to monitor clinical tuberculosis

  Evelin Dombay · Wilber Sabiiti · Daniela Alferes de Lima Headley · M. Bonifác Légrády · Nina van Campen · Sanne Zweijpfennig · Martin J. Boeree · Derek J. Sloan · Stephen H. Gillespie

  Frontiers in Antibiotics

  doi 10.3389/frabi.2026.1760862

• Original Research

  Published 8 April 2026

  Synergistic efficacy of combined neurolysis and methylcobalamin in peripheral nerve injury: a randomized clinical trial

  Xuwei Hu · Zuoshi Li

  Frontiers in Integrative Neuroscience

  doi 10.3389/fnint.2026.1747898

• Review

  Published 6 April 2026

  Traditional medicine and natural product based therapeutics in gingivitis management and microbial interactions

  Pranita Rath · Sudipta Kumar Patra · Manisha Dash · Sandeep Kumar Behera · Shibani Mohapatra · Kabir Suman Dash · Alok Kumar Panda

  Frontiers in Antibiotics

  doi 10.3389/frabi.2026.1764314

• Review

  Published 1 April 2026

  A registry-based systematic review of lifestyle and non-pharmaceutical oncology interventions in Africa

  Monica Wangari · Eunice Njoroge · Grace Mburu · Brenda Mogeni · Luke Ouma

  Frontiers in Cancer Control and Society

  doi 10.3389/fcacs.2026.1571038

• Systematic Review

  Published 1 April 2026

  Nanoparticle-mediated mRNA delivery for cancer, autoimmunity, and genetic diseases: a rapid review

  Okechukwu Paul-Chima Ugwu · Fabian C. Ogenyi · Mariam Basajja · Chinyere N. Ugwu · Mundu M. Mustafa · Michael Ben Okon

  Frontiers in Drug Delivery

  doi 10.3389/fddev.2026.1793322

• Study Protocol

  Published 31 March 2026

  Study protocol for the Vivistim GRASP registry: capturing real-world outcomes of paired vagus nerve stimulation in the chronic stroke population

  Shannon J. Doherty · Cecília N. Prudente · Reema Adham Hinds · David Pierce · Navzer D. Engineer · John Carrithers · Diana Hansen · W. Brent Tarver

  Frontiers in Stroke

  doi 10.3389/fstro.2026.1751659