Hypothesis and Theory
Published
Coherence, transformation, and breakdown in living systems: part I — the common higher-order regulatory architecture (CHORA) hypothesis
Andreas Nicolaides
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1910966
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 327 articles
Original Research
Published
A data-driven and interpretable hybrid quantum-classical model for male infertility risk assessment
T. Sarath · K. Brindha
Frontiers in Medical Technology
doi 10.3389/fmedt.2026.1853728
Hypothesis and Theory
Published
Algorithmic hyperindividualisation and the transformation of vulnerability in substance use prevention
Christoph Dockweiler · Carlotta Louisa Westfeld · Tessa Schulenkorf
Frontiers in Digital Health
doi 10.3389/fdgth.2026.1956219
Systematic Review
Published
Tophaceous gout-related carpal tunnel syndrome and flexor tendon involvement: a systematic review
Ali Can Günenç · Mehmet Şefik Oruç
Frontiers in Surgery
doi 10.3389/fsurg.2026.1948883
Original Research
Published
Clinical and genetic features, surgical management, and longitudinal follow-up in two children with progressive osseous heteroplasia
Yuehan Yin · Binshan Zhao · Liying Sun · Wenyao Zhong · Dan Chen · Xiuli Zhao · Wen Tian
Frontiers in Genetics
doi 10.3389/fgene.2026.1883125
Perspective
Published
Beyond heartbeats: re-thinking interoception in autism through virtual reality and computational modelling
Sarune Savickaite · Ruichen Li · Yukie Nagai
Frontiers in Neural Circuits
doi 10.3389/fncir.2026.1934104
Original Research
Published
Women's empowerment and intimate partner violence among pregnant women in Northern Ghana: evidence from coarsened exact matching and double-selection LASSO analyses
Joseph Lasong · Yula Salifu · Yaa Nyarko Adjeso
Frontiers in Global Women's Health
doi 10.3389/fgwh.2026.1905930
Original Research
Published
Health literacy and patient engagement among Korean immigrants in the U.S.: exploring the emotional, cognitive, and behavioral dimensions
Seulgi Park · Rukhsana Ahmed
Frontiers in Communication
doi 10.3389/fcomm.2026.1894952
Original Research
Published
Exploring the potential targets and possible mechanisms of Shenqi Fuzheng Injection in the treatment of cancer-associated muscle wasting based on network pharmacology
Chen Liu · Ling Cheng · Wenfeng Ye · Lina Zhang
Frontiers in Genetics
doi 10.3389/fgene.2026.1876819
Original Research
Published
Prediction of cognitive impairment in Parkinson’s disease using TabPFN: an integrative analysis of clinical data, longitudinal trajectories, and lipidomics
Zikai Zhou · Jie Liu · Lijuan Wang · Hong Lv · Wencan Jiang · Ling Huang · Guojun Zhang · Ruimin Ma
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1905374
Original Research
Published
1 H NMR-based profiling and candidate prioritization of interaction-associated metabolites from fungal co-cultures
Mustapha N. Abubakar · Vitor S. Mazucato · Paulo C. Vieira
Frontiers in Natural Products
doi 10.3389/fntpr.2026.1879578
Community Case Study
Published
A person-centered continuity pathway for pediatric contrast-enhanced imaging: sustaining one multisensory context across home, hospital, and scanner transitions
Tommaso Liuzzi · Carmela Napolitano · Fiammetta D’Arienzo · Martina Frascari Diotallevi · Donatella Lettori · Andrea Magistrelli · Aurelio Secinaro
Frontiers in Health Services
doi 10.3389/frhs.2026.1940926
Review
Published
Olfactory dysfunction and submicroscopic abnormalities: unveiling hidden pathologies
Katarzyna Bilińska · Magdalena Pasińska · Fernando de Castro
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1861373
Case Report
Published
Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases
Scott Froum · Nathan Estrin · Gianna Pico · Mikhail Yakubov · Paras Ahmad · James LaValle
Frontiers in Oral Health
doi 10.3389/froh.2026.1907109
Original Research
Published
GWAS-based polygenic profiling across broad sport categories: shared and category-specific genetic associations with athlete status and polygenic differences from population controls
M. V. Terekhov · G. A. Abushinova · A. A. Mamchur · M. V. Bruttan · I. K. Dzhumaniiazova · M. V. Ivanov · A. V. Zholinsky · A. I. Kadykova · N. S. Gladyshev · R. V. Deev · L. R. Matkava · M. N. Pilipenko · S. I. Mitrofanov · A. A. Ivashechkin · E. D. Maralova · V. S. Yudin · V. V. Makarov · A. A. Keskinov · D. A. Kashtanova · S. M. Yudin · V. I. Skvortsova
Frontiers in Sports and Active Living
doi 10.3389/fspor.2026.1813231
Original Research
Published
Mapping DEHP-induced metabolic dysregulation through multi-omics and systems biology: an adverse outcome pathway network approach
Elisavet Renieri · Achilleas Karakoltzidis · Nafsika Papaioannou · Dayna R. Schultz · Thanasis Papageorgiou · Catherine Gabriel · Ilias S. Frydas · Kévin Bernal · Xavier Coumoul · Etienne B. Blanc · Normand Podechard · Hélène Le Mentec · Charbel Touma · Sophie Langouët · Talía Boronat-Belda · Hilda Ferrero · Paloma Alonso-Magdalena · Karine Audouze · Spyros Karakitsios · Dimosthenis A. Sarigiannis
Frontiers in Toxicology
doi 10.3389/ftox.2026.1930835
Perspective
Published
Women in Portuguese industrial microbiology: a fifty-year perspective on progress and persistent barriers
Teresa Semedo-Lemsaddek · Marta Laranjo · Maria José Saavedra
Frontiers in Industrial Microbiology
doi 10.3389/finmi.2026.1939832
Conceptual Analysis
Published
From eco-affective narrowing to agency: acceptance, externalization, and efficacy in climate-related cognition
Paolo Raile
Frontiers in Cognition
doi 10.3389/fcogn.2026.1927324
Hypothesis and Theory
Published
Operationalizing clinical artificial intelligence through secure FHIR pipelines: a zero-trust cloud reference architecture for EHR interoperability
Femi Oke
Frontiers in Digital Health
doi 10.3389/fdgth.2026.1953969
Original Research
Published
Circulating arginine–nitric oxide pathway metabolites and nitrated fatty acids in relation to pathological features of colorectal cancer
Jakub Klekowski · Paulina Fortuna · Łukasz Lewandowski · Gabriela Maciejewska · Wioleta Szewczak · Karolina Mosna · Marek Zawadzki · Mariusz Chabowski · Mariusz Fleszar
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1910147
Original Research
Published
Multimodal rehabilitation for hard flaccid syndrome in a retrospective case series
Christopher L. Mendias · Tariq M. Awan
Frontiers in Rehabilitation Sciences
doi 10.3389/fresc.2026.1970062
Hypothesis and Theory
Published
Periodontal Medicine 2.0: a framework for evidence-calibrated, integrated and patient-centred care
Marde Shraddha Kashinath · Geeta Mandavilli · Prathyusha Chava
Frontiers in Dental Medicine
doi 10.3389/fdmed.2026.1907427
Systematic Review
Published
Effects of exercise on cognitive function in older adults: a systematic review and meta-analysis of the mediating role of sleep
Wenhui Zheng · Mian Wu · Yuhe Chen · Shaolan Li · Liying Huang
Frontiers in Human Neuroscience
doi 10.3389/fnhum.2026.1949679
Hypothesis and Theory
Published
Trust your gut: the neuro-gastroenteric mechanics of prediction and expectation
Alessia Caccamo
Frontiers in Human Neuroscience
doi 10.3389/fnhum.2026.1956182
Hypothesis and Theory
Published
The food-system carbon data layer: integrating automated life-cycle-assessment digital twins into urban digital twins
Mohd Kamil Vakil · Mohamed Yusuf Alkoheji · Shahrukh Ahmad
Frontiers in Built Environment
doi 10.3389/fbuil.2026.1953330
Original Research
Published
High-precision universality? A matched-pair sawbone study on the learning curve, accuracy, and implant interchangeability of a novel open-platform robotic UKA system
Pengyu Zhan · Ziyue Liu · Boran Liang · Yugang Xing · Xingyu Liu · Yiling Zhang · Jing Chen
Frontiers in Robotics and AI
doi 10.3389/frobt.2026.1886514
Original Research
Published
Σ-Gravity: a coherence-motivated empirical response tested in galaxies and clusters
Leonard Speiser
Frontiers in Astronomy and Space Sciences
doi 10.3389/fspas.2026.1866133
Hypothesis and Theory
Published
A pragmatic workflow for integrating large language models into toxicological risk assessment
Arianna Bassan · Alexander Amberg · Maria Letizia Barreca · Paul M. Bradley · Frank Bringezu · Joyce De Paula Souza · Corinne Guicheney · Elena Lo Piparo · Simona Kovarich · Andrey Massarsky · Georgia Maundrill · Lance Molnar · Cristina Parenti · Patricia Parris · Manuela Pavan · John F. Reichard · Ron Steigerwalt · Olga Tcheremenskaia · Kenneth Unice · Christopher J. Waine · Geraldine Whelan · Angela White · Glenn J. Myatt
Frontiers in Toxicology
doi 10.3389/ftox.2026.1877128
Mini Review
Published
Generative models of living development: an interaction-centered proposal and its implications for artificial life research
Bin Yin · Xiao-Rui Wu
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1904510
Review
Published
HSV-1 infections of the prefrontal cortex: regional vulnerability, cellular mechanisms, and neurocognitive consequences
Hannah Chau · Julia Schurr · Jonna M. Leyrer-Jackson · Erin S. Honsa
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1887935
Original Research
Published
Combined effects of acoustics and indoor air quality on calculation performance: a laboratory experiment and a lab-dilemma investigation
Matteo Pellegatti · Chiara Visentin · Simone Torresin · Francesco Babich · Nicola Prodi
Frontiers in Built Environment
doi 10.3389/fbuil.2026.1869553
Hypothesis and Theory
Published
Heterochrony as temporal redistribution of developmental burden
Dong-Gyun Han
Frontiers in Ecology and Evolution
doi 10.3389/fevo.2026.1917585
Technology and Code
Published
singIST: an R/bioconductor library and quarto dashboard for automated single-cell comparative transcriptomics analysis of disease models and humans
Aitor Moruno-Cuenca · Sergio Picart-Armada · Alexandre Perera-Lluna · Francesc Fernández-Albert
Frontiers in Genetics
doi 10.3389/fgene.2026.1952333
Review
Published
Epigenetic, chromatin-associated, and epitranscriptomic regulation in chronic pain: mechanisms and translational prospects
Jianan You · Lei Li
Frontiers in Genetics
doi 10.3389/fgene.2026.1904744
Hypothesis and Theory
Published
Mentorship as metadata: clinical annotation and the limits of real-world data in oculoplastic surgery
Itay Nitzan · Tehila Shlomov · Zvi Gur
Frontiers in Ophthalmology
doi 10.3389/fopht.2026.1972892
Original Research
Published
Targeted modulation of thalamocortical and descending control networks in chronic shoulder pain: a longitudinal connectomics study
Li He · Wenjing Li · Lihang Gao · Xuan Du · Hongwei Ren · Qian Zhang · Yingchao Wu · Nicholas B. Dadario · Hongkai Chen · Michael E. Sughrue · Duanwei Wang · Hong Jin
Frontiers in Pain Research
doi 10.3389/fpain.2026.1794217
Hypothesis and Theory
Published
Infrared photons generated by voltage-gated sodium channel dynamics: a hypothesis for cooperative electrodynamic interactions at the axon initial segment
Daya Shankar Gupta
Frontiers in Human Neuroscience
doi 10.3389/fnhum.2026.1772352
Case Report
Published
Subjective experience of listening to favorite songs and Murottal Al-Qur’an in young adult women: a quantitative EEG case series
Kana Khairunnisa · Yusuf Alam Romadhon
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1903142
Hypothesis and Theory
Published
Cryptographically verifiable authorization for autonomous AI agents: a falsifiable hypothesis and proof of concept
Mar Llambí-Morillas · Daniel Fernández-Fernández
Frontiers in Computer Science
doi 10.3389/fcomp.2026.1966725
Original Research
Published
Contrasting groundwater flow systems in comparable African Mountains-role of permeability structure
Seifu Kebede · Sascha Roopa · Thapelo Mongala · Dereje Ayalew
Frontiers in Water
doi 10.3389/frwa.2026.1925623
Original Research
Published
Integrative multi-omics characterization of KLRB1/CD161 in diffuse large B-cell lymphoma: associations with immune context, subtype biology, and therapeutic response
Erwei Li · Yingying Tang · Yuanyuan Wanyan · Yu Liang
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1903725
Systematic Review
Published
Incidence, risk factors, and outcomes of contrast-associated acute kidney injury following interventional radiology procedures: a systematic review and meta-analysis
Saad Alhumaid · Mohammed Yousef Almulhim · Hessah Abdulaziz Al Hussaini · Qasem M. Alalwan · Hani Almohammed Ali · Sarah A. Al Ruzaihan · Fatima A. Aborshaid · Abdulrhman Khaled Al Abdulqader · Nourah Al Dossary · Muneera Alabdulqader · Shaden Saleh AlMousa · Khalid Suliman Aljoqiman
Frontiers in Radiology
doi 10.3389/fradi.2026.1947256
Original Research
Published
Neuro-psycho MMSig: multimodal mechanism enrichment platform for neuropsychiatric disorders
Vinay Srinivas Bharadhwaj · Karim S. Shalaby · Sathvik Guru Rao · Bruce Schultz · Jiayuan Zhang · Daniel Domingo-Fernández · Martin Hofmann-Apitius · Alpha Tom Kodamullil
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1898607
Hypothesis and Theory
Published
Designing a human-in-the-loop AI iterative process for research writing: a framework for preserving productive struggle
Sarah A. Chauncey
Frontiers in Computer Science
doi 10.3389/fcomp.2026.1947835
Opinion
Published
Beyond fixed beats: adaptive musical entrainment for precision neurorehabilitation in neurodegenerative disorders
Benoît G. Bardy
Frontiers in Rehabilitation Sciences
doi 10.3389/fresc.2026.1909811
Hypothesis and Theory
Published
Accessory–vagal crosstalk at the jugular foramen: a hypothesis for reflex dry cough during posterior cervical extracorporeal shockwave therapy
Xuewen Jia
Frontiers in Rehabilitation Sciences
doi 10.3389/fresc.2026.1915218
Original Research
Published
Multivariate statistical analysis of chemical components, origin, variety, and sensory quality of domestic cigar tobacco leaves
Cai Wen · An Hongyue · Liu Jie · Zhang Qianying · Huang Mingyue · Chai Zhishun · Zhu Beibei · Huo Danqun · Li Dongliang
Frontiers in Chemistry
doi 10.3389/fchem.2026.1910376
Review
Published
How does thermal stratification restructure zooplankton ecological functions in reservoirs: a hypothesis based on self-organised criticality theory
Wangwei Cai · Xiaoran Gao · Si Chen
Frontiers in Ecology and Evolution
doi 10.3389/fevo.2026.1877227