Review
Published
Neuropeptide Y signaling in osteoarthritis pain: neuroimmune mechanisms, joint remodeling, and translational opportunities
Heng Qiu · Li Wang · Danni Luo · Yong Huang
Frontiers in Pain Research
doi 10.3389/fpain.2026.1884062
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Showing 328 articles
Perspective
Published
The importance of the life cycle perspective for safety assessment in the European Commission’s Safe and Sustainable by Design Framework
Irantzu Garmendia Aguirre · Irini Furxhi · Agnieszka Mech · Kirsten Rasmussen · Hubert Rauscher
Frontiers in Toxicology
doi 10.3389/ftox.2026.1909986
Review
Published
Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access
Patrick E. Sewell · Christopher Jensen
Frontiers in Drug Delivery
doi 10.3389/fddev.2026.1906950
Original Research
Published
Octopamine receptors in Drosophila larvae: expression, development, and behavior
Alexandra Großjohann · Vincent Richter · Franziska Reinhardt · Marvin Hahmann · Ronja Badelt · Juliane Kinnigkeit · Jana Breitfeld · Peter Kovacs · Peter F. Stadler · Irene Coin · Andreas S. Thum
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1876842
Review
Published
Activation of silent synapses driven by emerging technologies: mechanisms, disease associations, and prospects for clinical translation
Yongli Li · Yong Liao · Shouyao Zhang · Chenggui Xu · Ruhua Lan · Pengbin Zhao · Ruilu Liu · Yongli Song · Xinghe Zhang
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1923815
Review
Published
Beyond tobacco: understanding the growing burden of lung adenocarcinoma in women
Michael Christian A. Virata · Rizal Michael Ramos Abello · Edroico Mari Beltran Brillante · Jasmine Soco Interior · Patrick Reyes Relacion · Ryan Gabriel C. Molen · Eryll Paolo M. Alea · John Cedric P. Mojica
Oncology Reviews
doi 10.3389/or.2026.1813124
Mini Review
Published
Gut microbes and benign prostatic hyperplasia: the role of dysbiosis
Gordon Treacy · Katherine Dinan · Timothy G. Dinan
Frontiers in Urology
doi 10.3389/fruro.2026.1959570
Original Research
Published
Benchmarking protein-ligand co-folding across Nav, Cav and Kv-family channels
Yu Zhu · Taufiq Rahman
Frontiers in Biophysics
doi 10.3389/frbis.2026.1937302
Mini Review
Published
Toxicology of caffeine poisoning: molecular mechanisms, toxicokinetic profiles, and clinical implications
Antonia Socias · Rafael Blancas
Frontiers in Toxicology
doi 10.3389/ftox.2026.1933375
Review
Published
Decoding RAGE in diabetes: a pathogenic signaling hub modulated by decoy receptors in diabetic complications
Yupa Srithongchai · Ai Harashima · Seiichi Munesue · Kumi Kimura · Yu Oshima · Mariko Tanaka · Hiroya Takahashi · Pathitta Sakulsak · Chisato Uramoto · Nontaphat Leerach · Yasuhiko Yamamoto
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1854214
Perspective
Published
Cardiometabolic drugs after stroke: time to embrace SGLT2 inhibitors and incretin-based therapies?
Håkon Ihle-Hansen · Hege Ihle-Hansen · Rolf A. Blauenfeldt · Jesse Dawson · Søren Z. Diederichsen · Guri Hagberg
Frontiers in Stroke
doi 10.3389/fstro.2026.1918465
Review
Published
Bionic vision technologies: progress and perspectives on retinal prostheses and optogenetics for the treatment of advanced retinal degeneration
Na Long · Meng Si · Yin Jiang · Fan Chen · Bei Chen · Fei Jiang · Shangang Pan · Xueqin Chu · Huarong Wu
Frontiers in Medical Technology
doi 10.3389/fmedt.2026.1898982
Hypothesis and Theory
Published
Relative Sertoli-cell FSH hyporesponsiveness as a potential contributor to sperm DNA fragmentation: a hypothesis-driven narrative review and proposal of the FERTILE framework
Hussein Kandil
Frontiers in Urology
doi 10.3389/fruro.2026.1915445
Mini Review
Published
T-cell exhaustion in leprosy: molecular mechanisms and therapeutic implications
Pragati Pandey · Sunil Dogra · Tarun Narang · Keshav Sharma · Seema Chhabra
Frontiers in Tropical Diseases
doi 10.3389/fitd.2026.1894675
Original Research
Published
A TRPA1-mediated substance P release assay as an in vitro screening tool for airway irritant potential
R. Bedford · R. Medhane · J. Lawrance · M. Hollings
Frontiers in Toxicology
doi 10.3389/ftox.2026.1870419
Mini Review
Published
Glucagon like peptide 1 receptor agonists in patients with inflammatory bowel disease: safety, clinical effectiveness and anti-inflammatory mechanisms
Shannon Fernando · Joy Zhao · Kevan Josloff · Nida Zubair · Aakash Desai · Raina Shivashankar · Patricia L. Kozuch · Cuckoo Choudhary · Gary Lichtenstein · Priya Sehgal
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1864456
Review
Published
Opioid receptor agonist–antagonists in pain management: receptor specific mechanisms, dose response relationships, and clinical combination strategies
Sining Zhao · Zhiqiang Xue · Shu Wang
Frontiers in Pain Research
doi 10.3389/fpain.2026.1903184
Original Research
Published
Rotenone-induced oxidative stress triggers peroxisomal alterations in BV-2 microglial cells
Alessio Valenza · Maurizio Muzzi · Francesca Rendina · Irene Montali · Daniele Pensabene · Anna Fracassi · Marco Segatto · Sandra Moreno
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1941513
Original Research
Published
Oxytocin specifically participates in social memory encoding by exciting stellate neurons in the lateral entorhinal cortex
Jinquan Wang · Feng Cai · Qi Zhu · Zijian Song · Hao Zhang · Haiyan Wang · Jiaxiang Duan · Hua Huang · Yi Xu
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1834610
Original Research
Published
A new high-accuracy QSAR model based on ultra-curated data for predicting thyroid receptor-related endocrine activity
Emel Ay-Albrecht · Zlatomir Todorov · Franklin J. Bauer · Marie Darracq-Ghitalla-Ciock · Carole Charmeau-Genevois · Satinder S. Sarang · Paul C. Thomas
Frontiers in Toxicology
doi 10.3389/ftox.2026.1852502
Hypothesis and Theory
Published
A minimal three-arm oral regimen for healthspan: mechanistic alignment with transcriptomic signals from a large parental-lifespan GWAS
Ngo Cheung
Frontiers in Aging
doi 10.3389/fragi.2026.1856979
Original Research
Published
Boldine treatment prevents chronic cognitive impairment and exaggerated fear learning in rats exposed to repetitive low-level blast injury
Georgina Perez Garcia · Gissel M. Perez · Rita De Gasperi · Miguel A. Gama Sosa · Serena Yeung · Carolyn W. Zhu · Patrick R. Hof · Jiangping Pan · Shahrukh Khalique · Alexey Kozlenkov · Wei Zhao · Carlos A. Toro · Gregory A. Elder · Christopher P. Cardozo
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1894226
Perspective
Published
Geranylgeranoic acid, toll-like receptor 4, and pyroptosis-related signaling in hepatocellular carcinoma: a hypothesis-generating perspective
Yuki Tabata
Oncology Reviews
doi 10.3389/or.2026.1882953
Review
Published
The ERK MAPK pathway in mesenchymal glioblastoma: tumorigenesis, microenvironmental reprogramming, and the therapeutic promise of RAS(ON) multi-selective inhibition
Uma M. Basole · Mary M. Fitzpatric · Joseph Donohoe · Shashank Obulasetti · William Snider · Emily Haugen · Damir Garcia · Ana Gonzalez-Manteiga · Mathieu Sertorio · Marc Oria
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1857885
Original Research
Published
Molecular dynamics simulation of the truncated NMDA receptor in a partially restrained active-like state
Xing Liu · Wenjun Zheng
Frontiers in Chemical Biology
doi 10.3389/fchbi.2026.1894245
Original Research
Published
Comparative transcriptomic analysis of functional and metabolic changes in mass-reared and wild Anastrepha ludens Loew (Diptera: Tephritidae)
Carlos Eduardo Aguilar-Castillo · Obdulia Lourdes Segura-León · Juan Cibrián-Tovar · Héctor González-Hernández · Juan Núñez-Farfán · Brenda Torres-Huerta
Frontiers in Insect Science
doi 10.3389/finsc.2026.1913379
Original Research
Published
Gap junction protein connexin 36 proteostatic mechanisms in photoreceptor cells subjected to excitotoxic stress
Monika Katan · Klaudia Mróz · Joanna Lewin-Kowalik · Adrian Smędowski
Acta Biochimica Polonica
doi 10.3389/abp.2026.16091
4,342 views
Review
Published
The menopause-obesity axis in MASH progression: from estrogen decline to liver fibrosis
Anastasia Ntikoudi · Eugenia Vlachou
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1889458
Review
Published
Functional genomics–guided design of CAR-T and CAR-NK therapies in hematological malignancies: aligning cellular engineering with immune escape and microenvironmental resistance
Shiqi Cai · Yang Tan · Qian Yang · Juan Huang
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1878460
Brief Research Report
Published
Bone morphogenetic protein 4-associated mitochondrial dysfunction in diabetic nephropathy involves Parkin downregulation
Masanori Tamaki · Tatsuya Tominaga · Kazuhiro Hasegawa · Takahiro Kida · Shinji Miyakami · Ikuko Shimizu · Sumiyo Yamaguchi · Masanori Minato · Kojiro Nagai · Shu Wakino
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1860424
Original Research
Published
Investigating angiotensin II concentration in modulating Plasmodium falciparum infection and angiotensin receptor activation
Auley De · Aparna Tiwari · Medha Agarwal · Veena Pande · Abhinav Sinha
Frontiers in Parasitology
doi 10.3389/fpara.2026.1852476
Review
Published
FcεRII (CD23) in dermatological disorders: structure, function, and clinical implications
Natalia Zdanowska · Wiktoria Nowik-Zając · Joanna Czerwińska · Joanna Najbar · Agnieszka Owczarczyk-Saczonek
Frontiers in Allergy
doi 10.3389/falgy.2026.1849342
Original Research
Published
Glucagon-like peptide-1 receptor agonist versus other anti-diabetic agents on patients with prostate cancer undergoing androgen-deprivation therapy
Sheng-Chi Huang · Wan-Yu Cheng · Cheng-You Hou · Jheng-Yan Wu · Chih-Cheng Lai · Wen-Hsin Tseng
Frontiers in Urology
doi 10.3389/fruro.2026.1855180
Original Research
Published
Spectral analysis and AI/ML-based data-driven approaches for enhanced protein conformation selection and prediction in drug discovery
Shivangi Gupta · Vineetha Menon · Jerome Baudry
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1805731
Original Research
Published
α5-containing nicotinic acetylcholine receptors regulate state transitions in cortical networks and modulate susceptibility to epileptiform discharges
Ani Kaplanian · Michael Vinos · Uwe Maskos · Irini Skaliora
Frontiers in Neural Circuits
doi 10.3389/fncir.2026.1858893
Case Report
Published
Case Report: Recurrent hypoglycemia due to graft-derived insulinoma in a patient with type 1 diabetes following pancreas-kidney transplantation
Carme Figueredo · Maria Iraola · Marta Aymerich · Neus Villamor · Ivan Archilla · Joana Ferrer-Fàbrega · Antonio J. Amor · Pedro Ventura-Aguiar
Frontiers in Transplantation
doi 10.3389/frtra.2026.1889705
Original Research
Published
Expression and RNAi characterization of neuropeptides underlying developmental regulation in the Colorado potato beetle
Emma E. Terris · Sophie M. Verkoulen · Russell L. Groves · Steven Moen · Sean D. Schoville · Morgan Weissner · Umut Toprak
Frontiers in Insect Science
doi 10.3389/finsc.2026.1862257
Case Report
Published
Eosinophilic cystitis refractory to multiple treatments with good response to benralizumab: case report
Marina Ruiz de Galarreta Beristain · María Teresa Audicana Berasategui · Nagore Bernedo Belar · Cristina Mena Ruiz · Virginia Moreno Nieto · Olga Uriel Villate
Frontiers in Allergy
doi 10.3389/falgy.2026.1890965
Review
Published
Circulating tumour DNA in mCRPC: bridging tumour biology and real-time treatment monitoring
Chimbabantu Kaoma · Mike Sathekge · Joseph Chalwe · Kgomotso Mokoala · Mankgopo Kgatle
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1852641
Case Report
Published
Case Report: Non-invasive [ 89 Zr]Zr-DFO-trastuzumab positron emission tomography in the multimodal characterisation of platinum-resistant high-grade serous ovarian cancer
Joana do Mar Ferreira Machado · Robert Winzer · Rudi Apolle · Almuth Forberger · Kristof Zarschler · Torsten Knieß · Martin Kreller · Klaus Kopka · Oliver C. Kiß · Jan Dominik Kuhlmann · Pauline Wimberger · Matthias Miederer · Theresa Link
Frontiers in Nuclear Medicine
doi 10.3389/fnume.2026.1832138
Mini Review
Published
Glioblastoma as a neuro-immune network disorder: rethinking the tumor microenvironment, neural circuit integration, and therapeutic resistance
Tyler Lo · Armando Bunjaj · Jeffrey P. Turnbull · Shivum Desai · Ammar Alsalahi · Heather Heitkotter · Daniel W. Griepp · Boyd F. Richards
Oncology Reviews
doi 10.3389/or.2026.1906725
Original Research
Published
Perinatal antibiotics in a db/db mouse model impact obesity and hyperglycemia in a microbiome-dependent manner
Noelle Curtis-Joseph · Audra Laubi · Melanie Ortiz-Alvarez de la Campa · Peter Belenky
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1750320
Review
Published
Light-sensing toolkit of cyanobacteria: photoreceptors, signaling and photomorphogenesis
Deepa Pandey · Sapna Tiwari · Priyul Pandey · Rinkesh Gupta · Anjali Gupta · Shailendra Pratap Singh
Frontiers in Plant Physiology
doi 10.3389/fphgy.2026.1834392
Original Research
Published
The role of gut microbiome disruption in the development of metabolic dysfunction-associated kidney disease
Michał Witkowski · Jarosław Przybyciński · Bartosz Wojciuk · Wiktor Czaja · Natalia Gołembiewska · Edyta Gołembiewska
Acta Biochimica Polonica
doi 10.3389/abp.2026.16436
1,289 views
Original Research
Published
Senecioylcholine in Heterometrus spinifer scorpion venom activates vertebrate nicotinic acetylcholine receptors
Rosa E. Prahl · Pratik Neupane · Angela A. Salim · Richard J. Lewis · Irina Vetter · Robert J. Capon · Glenn F. King · Volker Herzig
Frontiers in Arachnid Science
doi 10.3389/frchs.2026.1888189
Original Research
Published
SR9009 regulates macrophage polarization via the NR1D1/NF-κB axis to ameliorate obesity-associated ulcerative colitis
Zhixue Zheng · Xuan Cai · Yaqi Liu · Jingtao Bi
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1762028
Review
Published
A hierarchical integration model of effort perception: peripheral, central, cognitive, temporal, and applied mechanisms revealed through blood flow restriction
Yudai Takarada
Frontiers in Neuroergonomics
doi 10.3389/fnrgo.2026.1811504
Original Research
Published
Heterosynaptic NMDA receptor plasticity in hippocampal dentate granule cells
Kaoutsar Nasrallah · Maryann Castillo · Stefano Lutzu · Pablo E. Castillo · Alma Rodenas-Ruano
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1825949