Review
Published
Fundamentals of dermatologic drug discovery
Ayman Grada
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1777138
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 354 articles
Hypothesis and Theory
Published
Neuroinflammation as a failure of allostatic integrity: a hierarchical-circular model of biological memory for pathogenesis in neurodegenerative and neuropsychiatric diseases
Samuel Ruesga Mundo
Frontiers in Systems Neuroscience
doi 10.3389/fnsys.2026.1888548
Original Research
Published
Smartphone-measured tremor and tacrolimus trough levels in kidney transplant recipients: an exploratory prospective study
Annudesh Liyanage · Caitlin Schneider · Julien Renard · Rohit Singla · Jorden Hetherington · Steven Tang · Ted Hoyda · James Lan · Cindy Luo · David Harriman · Christopher Nguan
Frontiers in Transplantation
doi 10.3389/frtra.2026.1870210
Original Article
Published
Multimodal risk profiles reveal shared and disease-specific risks of major non-communicable diseases: a prospective cohort study of 42,666 individuals
Qiaoyi Xu · Zhenqiu Liu · Renjia Zhao · Zixuan Cui · Xufei Xing · Xingdong Chen · Chen Suo
International Journal of Public Health
doi 10.3389/ijph.2026.1609591
Review
Published
Autophagy in thyroid cancer: stage-dependent switch, mutation-specific regulation, and therapeutic targeting
Lihua Fang · Chaowen Wu · Huimin Sun · Jie Ning
Oncology Reviews
doi 10.3389/or.2026.1873752
Original Research
Published
Prognostic value of baseline 18 F-FDG PET/CT metabolic parameters in EGFR-mutant lung adenocarcinoma patients treated with EGFR-TKIs
Lei Wang · Zhenpeng Wang · Wei Wu
Frontiers in Nuclear Medicine
doi 10.3389/fnume.2026.1864776
Original Research
Published
A whole-transcriptome analysis of differentially expressed genes, transcripts, and transcript usage in blood samples from Parkinson’s disease patients
Sulev Koks · Mari Muldmaa · Jack Price · Luke Whiley · Maili Jakobson · Lewis Singleton · Denise Howting · Abigail L. Pfaff · Abha Chopra · Mark Watson · Katrin Sikk · Pille Taba
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11099
Editorial
Published
Editorial: Engineered nanomaterials: understanding their toxicity and environmental impacts
Sarmistha Saha · Brigitta Buttari · Luciano Saso
Frontiers in Nanotechnology
doi 10.3389/fnano.2026.1899853
Original Research
Published
Transcriptomics-based identification of shared biomarkers across type 2 diabetes, mild cognitive impairment, and uric acid metabolism
Yan Liu · Dongmei Kang · Yuan Lei
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11060
Brief Research Report
Published
Reproducible candidate kinematic-electromyographic waveform markers of post-stroke gait from public multimodal waveform exports
Rocco Salvatore Calabrò · Andrea Calderone · Fabrizio Sottile · Carmela Casella · Antonino Naro · Gokhan Ozkocak · Angelo Quartarone
Frontiers in Medical Technology
doi 10.3389/fmedt.2026.1863908
Original Research
Published
Early identification of PRISm from chest CT: a multimodal for three-class stratification of normal, PRISm, and COPD
Yan Mou · Xueqing Bian · Na Tian · Zheng Xia · Jinbo Shi · Ming Li · Zhimin Shao · Lin Qi · Haiyan Ge · Miao Huang
Frontiers in Radiology
doi 10.3389/fradi.2026.1829853
Original Research
Published
Pemafibrate is associated with greater reductions in MDA-LDL and small dense LDL fractions with exploratory PBMC gene-expression changes: a prespecified subanalysis of the PARADISE in Kagoshima study
Toru Kubo · Takahisa Deguchi · Kaori Matsuzaki · Atsushi Shinnakasu · Shigeru Kawade · Aiko Arimura · Hiroshi Hashiguchi · Kazuma Ogiso · Tetsuro Kamada · Mihoko Kurano · Katsutaro Morino · Yoshihiko Nishio
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1850470
Original Research
Published
Comparison of SOFA score alone versus SOFA score with interleukin-6 for outcome prediction in ICU patients with sepsis: a prospective observational study
Lalit Gupta · Anuradha Dialani · Shashank N. P. · Kapil Chaudhary
Frontiers in Anesthesiology
doi 10.3389/fanes.2026.1861908
Original Research
Published
Plasma proteomics based on machine learning predict the early risk of kidney outcomes in patients with DKD: a prospective cohort study from UK Biobank
Li Jiang · Tingting Li · Haojun Zhang · Xiai Wu · Tingting Zhao
Frontiers in Nephrology
doi 10.3389/fneph.2026.1862772
Review
Published
The nano-neuro nexus: smart sensors at the frontier of detecting neurodegeneration
Arpit Mehrotra · Abhilasha Sood · Shraddha Yadav · Aditi D. Raval · S. Renuka Jyothi · Ashok Kumar Sah · Chandan Sharma · Laxmidhar Maharana
Frontiers in Nanotechnology
doi 10.3389/fnano.2026.1843615
Frontiers in Science Viewpoint
Published
Treg therapy needs better trials
Fadi Issa · Kathryn Wood
Frontiers in Science
doi 10.3389/fsci.2026.1874873
Hypothesis and Theory
Published
Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer’s disease and related dementias
Samuel Ruesga Mundo
Frontiers in Dementia
doi 10.3389/frdem.2026.1841647
Review
Published
Bidirectional regulatory mechanisms and therapeutic prospects of tumor hypercoagulable state and immunosuppressive tumor microenvironment
Yongli Lai · Ruyu Qin · Zhaidong Liu
Oncology Reviews
doi 10.3389/or.2026.1863533
Mini Review
Published
Medical and social challenges awaiting adolescents with congenital adrenal hyperplasia
M. Nixon · J. H. Davies
Frontiers in Adolescent Medicine
doi 10.3389/fradm.2026.1870467
Review
Published
B vitamins intake and cancer risk: a structured narrative review of evidence on riboflavin, pyridoxine, cobalamin and folate
Alexander Bertuccioli · Chiara Maria Palazzi · Irene Asia Massaro · Massimiliano Cazzaniga · Ilaria Cavecchia · Maria Rosaria Matera · Valentina Biagioli · Luca Imperatori · Francesco Di Pierro · Annalisa Belli
Pathology and Oncology Research
doi 10.3389/pore.2026.1612380
Systematic Review
Published
Leveraging artificial intelligence for analysis of the gut microbiome for dementia diagnosis: a scoping review and discussion
Laya Krishnan · Gaurie Gunasekaran · Tamanna Dhore · Alexa Lauinger · Vijaya Kolachalama · Suguna Pappu
Frontiers in Dementia
doi 10.3389/frdem.2026.1865441
Review
Published
Artificial intelligence–driven multimodal fusion for precision diagnosis and personalized management of breast cancer
Mingyu Zhang · Juhang Chu · Zixin Wang · Yaru Wang · Luyao Huang · Mingping Qian
Oncology Reviews
doi 10.3389/or.2026.1849152
Original Research
Published
Association of MMP-2 and hematological parameters with breast cancer metastasis: a cross-sectional study in Central Java, Indonesia
Alyssa Imani · Yan Wisnu Prajoko · Rudi Nirwantono · Fitya Syarifa Mozar · Bens Pardamean · Edward Kurnia Setiawan Limijadi
Oncology Reviews
doi 10.3389/or.2026.1818926
Original Research
Published
Glioma identification from microRNA biomarkers using machine learning
Rakesh Kanth Andugala · Alyson Cieslik · Maria Braoudaki · Iosif Mporas
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1771910
Perspective
Published
Predictive modeling for cervical cancer: existing AI approaches and the emerging role of vaginal microbiome
Michelle Gomes · Zonglun Li · Adeola Olaitan · Aleksandra Gentry-Maharaj
Frontiers in Network Physiology
doi 10.3389/fnetp.2026.1799486
Review
Published
Vector-amplified toxicity of microplastics and heavy metals in aquatic invertebrates: mechanistic insights and implications for sustainable aquaculture
Jaynos R. Cortes · John Lloyd F. Penionez · Jay D. Tering · Fabio C. Ruaza
Frontiers in Aquaculture
doi 10.3389/faquc.2026.1841755
Original Research
Published
Variability and longitudinal dynamics of donor-derived cell-free DNA in kidney and liver recipients: a comparison of absolute and relative quantities in plasma and urine
Fanny Sandberg · Nicholas Kueng · Vanessa Banz · Annalisa Berzigotti · Daniel Sidler · Carlo R. Largiadèr · Ursula Amstutz
Frontiers in Transplantation
doi 10.3389/frtra.2026.1790754
Original Research
Published
Decoding basal ganglia motor circuit dysfunction from handwriting: a physics-informed neural signal interpretation framework for Parkinson's disease screening
Krishnan Batri · S. Lakshmi · Salabat Khan · Zeshan Iqbal · Mohammad Alhefdi · Ghada Atteia · Sivaram Murugan
Frontiers in Neuroinformatics
doi 10.3389/fninf.2026.1814920
Brief Research Report
Published
The chronical outcome monitoring in dystonia with deep brain stimulation (COMEDD) study protocol: a longitudinal evaluation of chronic electrophysiological biomarkers in patients with dystonia and deep brain stimulation therapy
Lucia K. Feldmann · Jonathan Kaplan · Ana Luisa de Almeida Marcelino · Daniel Schulze · Andrea A. Kühn
Dystonia
doi 10.3389/dyst.2026.16304
Editorial
Published
Editorial: Pathophysiology of diabetic kidney disease
Oscar Lorenzo
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1872162
Original Research
Published
Detection of bacterial and viral pneumonia in pediatric chest radiographs using fusion of mediastinum and lung imaging biomarkers
Sukanta Kumar Tulo · Shilpi Ruchi Kerketta · O. Rahul Manohar · Pramod Martha
Frontiers in Signal Processing
doi 10.3389/frsip.2026.1831207
Systematic Review
Published
Environmental epigenetic modifiers in neurodegenerative diseases: a systematic review of epigenomic mechanisms and therapeutic targets
Pranay Wal · Sunita Mishra · Debashish Pradhan · Ankita Wal · Debashis Purohit · Lalit Mohan Nainwal · Vivek Dhir · Amin Gasmi
Frontiers in Epigenetics and Epigenomics
doi 10.3389/freae.2026.1833533
Review
Published
Research overview—2025: integrating scientific progress to accelerate global tuberculosis elimination
Patrick K. Moonan · Timothy H. Holtz
Frontiers in Tuberculosis
doi 10.3389/ftubr.2026.1805962
Original Research
Published
Blood biomarkers and atrial remodeling in patients at risk of atrial fibrillation
Filip Loncaric · Ilana Forado Benatar · Maria Mimbrero Guillamon · Loredana Nunno · Rafael Jimenez-Arjona · Laia Tirapu · Sílvia Montserrat · Laura Sanchis · Adelina Doltra · Bart Bijnens · Marta Sitges
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1801523
Original Research
Published
Structural brain lesions and action observation therapy outcomes in unilateral cerebral palsy: an exploratory study
Francy Cruz-Sanabria · Elena Beani · Valentina Menici · Silvia Filogna · Paolo Bosco · Simona Fiori · Laura Biagi · Giuseppina Sgandurra
Frontiers in Systems Neuroscience
doi 10.3389/fnsys.2026.1766684
Review
Published
Pathogenesis of diabetic cardiomyopathy and emerging therapeutic strategies: a network-based perspective
Haoqing Ren · Hengli Lai
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1823872
Brief Research Report
Published
Prenatal environmental chemical exposures and child IQ: sex-specific effects in the MIREC cohort
Meaghan Hall · Jillian Ashley-Martin · Tye E. Arbuckle · Christine Till
Frontiers in Environmental Health
doi 10.3389/fenvh.2026.1788769
Original Research
Published
Reliability and diagnostic performance of an automated MRI-based classifier compared with radiologists in Alzheimer’s disease
Nurmakhan Zholshybek · Elnora Abdurakhmanova · Almas Bimakhan · Dinara Jumadilova · Zhanibek Baiturlin · Joseph Almazan · Srinivasa Rao Bolla
Frontiers in Neuroinformatics
doi 10.3389/fninf.2026.1821249
Original Research
Published
Peripheral immune cells and glycation indices as potential diagnostic biomarkers in amyotrophic lateral sclerosis
Xue Yang · Jing Yang · Rui Li · Hui Dong · Yaling Liu
Experimental Biology and Medicine
doi 10.3389/ebm.2026.10987
Original Research
Published
Identifying microbial biomarkers of neurodegeneration: a comparative study in Alzheimer’s and Parkinson’s disease
Simon De Jaegher · David Pinzauti · Maria D’Aguanno · Erika Parkinson · James Schofield · Fabio Strazzeri · Paul Skipp · Rebekah Penrice-Randal · Amy Kunicki · Beth McCausland · Christopher Kipps · Jay Amin · Manuele Biazzo
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1831956
Review
Published
Advancements in cancer biomarker discovery over fifteen years: diagnostics and prognostic approach in somatic cancer
Mohd Basheeruddin · Sana Qausain · Ashish Anjankar · Faez Iqbal Khan
Oncology Reviews
doi 10.3389/or.2026.1809836
Review
Published
Imaging research, diagnosis, and treatment advances of post-stroke cognitive impairment
Mengyi Huang · Qunbo Jia · Yushu Ouyang · Xiaoteng Feng · Ronghui Ju
Frontiers in Neuroimaging
doi 10.3389/fnimg.2026.1691870
Review
Published
Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions
Yuexin Wu · Cuiying Zhang · Yangyang Peng · Longlong Liu
Experimental Biology and Medicine
doi 10.3389/ebm.2026.10997
Original Research
Published
Elevated ApoC3 levels in cerebrospinal fluid predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage
Bin Tong · Junjie Wang · Jiarui Chen · Qia Zhang · Zhouhan Xu · Kaichuang Yang · Xiaomin Chen
Experimental Biology and Medicine
doi 10.3389/ebm.2026.10827
Review
Published
Neuro-regulatory drug discovery (NRGDD): a neural-circuit framework for systemic therapeutic modulation
Sarfaraz K. Niazi
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1782364
Original Research
Published
Immunometabolic reprogramming of Mycobacterium tuberculosis -responsive memory CD4 + T cell subsets is linked to long-term protective immunity
Vaishnavi Kaipilyawar · Samantha Leong · Arianne Lovey · Lorenzzo L. Stringari · Reynaldo Dietze · Jerrold J. Ellner · Rodrigo Ribeiro-Rodrigues · Padmini Salgame
Frontiers in Tuberculosis
doi 10.3389/ftubr.2026.1783887
Original Research
Published
Simultaneous measurement of 16S-rRNA and pre-16S-rRNA as a strategy to monitor clinical tuberculosis
Evelin Dombay · Wilber Sabiiti · Daniela Alferes de Lima Headley · M. Bonifác Légrády · Nina van Campen · Sanne Zweijpfennig · Martin J. Boeree · Derek J. Sloan · Stephen H. Gillespie
Frontiers in Antibiotics
doi 10.3389/frabi.2026.1760862
Review
Published
Quadrupedal training approaches in post-stroke rehabilitation: a scoping review of evidence, mechanisms, and clinical applications
Jan A. Kuipers · Frederick R. Carrick · Monèm Jemni
Frontiers in Systems Neuroscience
doi 10.3389/fnsys.2026.1773330