Review
Published
Fundamentals of dermatologic drug discovery
Ayman Grada
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1777138
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 495 articles
Hypothesis and Theory
Published
Neuroinflammation as a failure of allostatic integrity: a hierarchical-circular model of biological memory for pathogenesis in neurodegenerative and neuropsychiatric diseases
Samuel Ruesga Mundo
Frontiers in Systems Neuroscience
doi 10.3389/fnsys.2026.1888548
Review
Published
Targeting glucocorticoid receptor signaling in platinum-resistant ovarian cancer: translational rationale and clinical advances following the ROSELLA trial
Wenxiang Wang · Zhanghuan Li · Junjie Zhao · Mengyuan Chang · Yafang Zhang · Xiangyi Shen · Junming Yue · John Schorge · Wenjing Zhang
Oncology Reviews
doi 10.3389/or.2026.1861081
Original Research
Published
Smartphone-measured tremor and tacrolimus trough levels in kidney transplant recipients: an exploratory prospective study
Annudesh Liyanage · Caitlin Schneider · Julien Renard · Rohit Singla · Jorden Hetherington · Steven Tang · Ted Hoyda · James Lan · Cindy Luo · David Harriman · Christopher Nguan
Frontiers in Transplantation
doi 10.3389/frtra.2026.1870210
Original Research
Published
Empirically constrained order parameter dynamics in cardiovascular criticality: a synergetic Langevin framework for arrhythmic transitions with cross-cohort parameter estimation and Kramers escape-time validation
Hiroyuki Okabe
Frontiers in Network Physiology
doi 10.3389/fnetp.2026.1865256
Original Article
Published
Multimodal risk profiles reveal shared and disease-specific risks of major non-communicable diseases: a prospective cohort study of 42,666 individuals
Qiaoyi Xu · Zhenqiu Liu · Renjia Zhao · Zixuan Cui · Xufei Xing · Xingdong Chen · Chen Suo
International Journal of Public Health
doi 10.3389/ijph.2026.1609591
Review
Published
Autophagy in thyroid cancer: stage-dependent switch, mutation-specific regulation, and therapeutic targeting
Lihua Fang · Chaowen Wu · Huimin Sun · Jie Ning
Oncology Reviews
doi 10.3389/or.2026.1873752
Original Research
Published
Spatial modeling of HIV prevalence in Malawi using generalized additive models
Zacharie Tsala Dimbuene · Crispin Mabika Mabika · Blandine Bawawana Bavwidinsi · Emmanuel Juakaly Wayisovia · Hugues Sampasa-Kanyinga
Frontiers in Epidemiology
doi 10.3389/fepid.2026.1867778
Original Research
Published
Prognostic value of baseline 18 F-FDG PET/CT metabolic parameters in EGFR-mutant lung adenocarcinoma patients treated with EGFR-TKIs
Lei Wang · Zhenpeng Wang · Wei Wu
Frontiers in Nuclear Medicine
doi 10.3389/fnume.2026.1864776
Original Research
Published
A whole-transcriptome analysis of differentially expressed genes, transcripts, and transcript usage in blood samples from Parkinson’s disease patients
Sulev Koks · Mari Muldmaa · Jack Price · Luke Whiley · Maili Jakobson · Lewis Singleton · Denise Howting · Abigail L. Pfaff · Abha Chopra · Mark Watson · Katrin Sikk · Pille Taba
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11099
Review
Published
Post-transplant lymphoproliferative disorder after solid organ transplantation: a comprehensive review
Lina Patricia Vargas-Nieto · Nicolás David Santoyo-Sarmiento · Maria Ballesteros-García · Angie Tatiana Calderón-Vásquez · Álvaro Daniel Pinto-Rodriguez · Maria Gabriela Robayo-Romero · Valeria Cormane-Alfaro · Jorge Daza-Buitrago
Frontiers in Transplantation
doi 10.3389/frtra.2026.1869288
Editorial
Published
Editorial: Engineered nanomaterials: understanding their toxicity and environmental impacts
Sarmistha Saha · Brigitta Buttari · Luciano Saso
Frontiers in Nanotechnology
doi 10.3389/fnano.2026.1899853
Original Research
Published
Transcriptomics-based identification of shared biomarkers across type 2 diabetes, mild cognitive impairment, and uric acid metabolism
Yan Liu · Dongmei Kang · Yuan Lei
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11060
Brief Research Report
Published
Reproducible candidate kinematic-electromyographic waveform markers of post-stroke gait from public multimodal waveform exports
Rocco Salvatore Calabrò · Andrea Calderone · Fabrizio Sottile · Carmela Casella · Antonino Naro · Gokhan Ozkocak · Angelo Quartarone
Frontiers in Medical Technology
doi 10.3389/fmedt.2026.1863908
Original Research
Published
Early identification of PRISm from chest CT: a multimodal for three-class stratification of normal, PRISm, and COPD
Yan Mou · Xueqing Bian · Na Tian · Zheng Xia · Jinbo Shi · Ming Li · Zhimin Shao · Lin Qi · Haiyan Ge · Miao Huang
Frontiers in Radiology
doi 10.3389/fradi.2026.1829853
Original Research
Published
Pemafibrate is associated with greater reductions in MDA-LDL and small dense LDL fractions with exploratory PBMC gene-expression changes: a prespecified subanalysis of the PARADISE in Kagoshima study
Toru Kubo · Takahisa Deguchi · Kaori Matsuzaki · Atsushi Shinnakasu · Shigeru Kawade · Aiko Arimura · Hiroshi Hashiguchi · Kazuma Ogiso · Tetsuro Kamada · Mihoko Kurano · Katsutaro Morino · Yoshihiko Nishio
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1850470
Hypothesis and Theory
Published
Autonomic-salience stability as a candidate Gate for awake low-dose ketamine: a systems neuroscience framework with a clinical anchor
Kei Torii · Maho Jinno
Frontiers in Systems Neuroscience
doi 10.3389/fnsys.2026.1880737
Original Research
Published
Comparison of SOFA score alone versus SOFA score with interleukin-6 for outcome prediction in ICU patients with sepsis: a prospective observational study
Lalit Gupta · Anuradha Dialani · Shashank N. P. · Kapil Chaudhary
Frontiers in Anesthesiology
doi 10.3389/fanes.2026.1861908
Original Research
Published
Plasma proteomics based on machine learning predict the early risk of kidney outcomes in patients with DKD: a prospective cohort study from UK Biobank
Li Jiang · Tingting Li · Haojun Zhang · Xiai Wu · Tingting Zhao
Frontiers in Nephrology
doi 10.3389/fneph.2026.1862772
Review
Published
The nano-neuro nexus: smart sensors at the frontier of detecting neurodegeneration
Arpit Mehrotra · Abhilasha Sood · Shraddha Yadav · Aditi D. Raval · S. Renuka Jyothi · Ashok Kumar Sah · Chandan Sharma · Laxmidhar Maharana
Frontiers in Nanotechnology
doi 10.3389/fnano.2026.1843615
Systematic Review
Published
Changes in cortical plasticity induced by paired associative stimulation in people with mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis
Xiaying Fu · Xiaomin Niu · Xiaoying Lin · Wenqi He · Chunyang Liao · Tiantian Xin · Shuqin Li · Sharie Xiao Wang · Jae Q. J. Liu · Bin Li · Jianghua Cheng
Frontiers in Neural Circuits
doi 10.3389/fncir.2026.1853684
Original Research
Published
Arsenic induced Hippo pathway dysregulation linked to hTERT hypo-methylation in breast cancer patients
Archana Chaudhary · Manish Kumar · Lalit Mohan · Abhay Kumar · Rishikesh Kumar · Shailesh Kumar · Kumar Pranay · Nandani Kumari · Rizwanul Haque · Md. Margoob Ahmad
Frontiers in Epigenetics and Epigenomics
doi 10.3389/freae.2026.1853054
Frontiers in Science Viewpoint
Published
Treg therapy needs better trials
Fadi Issa · Kathryn Wood
Frontiers in Science
doi 10.3389/fsci.2026.1874873
Hypothesis and Theory
Published
Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer’s disease and related dementias
Samuel Ruesga Mundo
Frontiers in Dementia
doi 10.3389/frdem.2026.1841647
Review
Published
Impact of plant-based interventions on gynecological cancers: a narrative review of mechanistic interplays and clinical evidence
Fidelis Batale Fabrael · John Sotunsa · Kehinde Samuel Olaniyi · Onome Bright Oghenetega · Oluwatobi Adewale · Blessing Monica Akindele · Faith Olanrewaju · Nekabari Lekpa Gbimadee · Seyi Olayemi · Abosede Oreoluwa Bolaji · Marvellous Osewe Iyobhebhe · Emmanuel Mololuwa Adegbotoluwa · Emmanuel Damilare Folahanmi · John Ahmadu Kaisar · Precious Adeoye Oyedokun
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1832188
Review
Published
Bidirectional regulatory mechanisms and therapeutic prospects of tumor hypercoagulable state and immunosuppressive tumor microenvironment
Yongli Lai · Ruyu Qin · Zhaidong Liu
Oncology Reviews
doi 10.3389/or.2026.1863533
Mini Review
Published
Medical and social challenges awaiting adolescents with congenital adrenal hyperplasia
M. Nixon · J. H. Davies
Frontiers in Adolescent Medicine
doi 10.3389/fradm.2026.1870467
Review
Published
B vitamins intake and cancer risk: a structured narrative review of evidence on riboflavin, pyridoxine, cobalamin and folate
Alexander Bertuccioli · Chiara Maria Palazzi · Irene Asia Massaro · Massimiliano Cazzaniga · Ilaria Cavecchia · Maria Rosaria Matera · Valentina Biagioli · Luca Imperatori · Francesco Di Pierro · Annalisa Belli
Pathology and Oncology Research
doi 10.3389/pore.2026.1612380
Systematic Review
Published
Leveraging artificial intelligence for analysis of the gut microbiome for dementia diagnosis: a scoping review and discussion
Laya Krishnan · Gaurie Gunasekaran · Tamanna Dhore · Alexa Lauinger · Vijaya Kolachalama · Suguna Pappu
Frontiers in Dementia
doi 10.3389/frdem.2026.1865441
Review
Published
Artificial intelligence–driven multimodal fusion for precision diagnosis and personalized management of breast cancer
Mingyu Zhang · Juhang Chu · Zixin Wang · Yaru Wang · Luyao Huang · Mingping Qian
Oncology Reviews
doi 10.3389/or.2026.1849152
Original Research
Published
Comparison of antibody immobilization on renewable nanocrystals for paper-based detection
Ketzalzin Vazquez-Hernandez · Beatriz M. Herrera · Clara Dourado Fernandes · Eno-Jane Effanga · Houra Farkhondehnia · Reshma Panackal Shibu · Julia L. Shamshina · Christopher Turner · Noureddine Abidi · Diego Gomez-Maldonado
Frontiers in Biomaterials Science
doi 10.3389/fbiom.2026.1815047
Original Research
Published
Association of MMP-2 and hematological parameters with breast cancer metastasis: a cross-sectional study in Central Java, Indonesia
Alyssa Imani · Yan Wisnu Prajoko · Rudi Nirwantono · Fitya Syarifa Mozar · Bens Pardamean · Edward Kurnia Setiawan Limijadi
Oncology Reviews
doi 10.3389/or.2026.1818926
Original Research
Published
Glioma identification from microRNA biomarkers using machine learning
Rakesh Kanth Andugala · Alyson Cieslik · Maria Braoudaki · Iosif Mporas
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1771910
Perspective
Published
Predictive modeling for cervical cancer: existing AI approaches and the emerging role of vaginal microbiome
Michelle Gomes · Zonglun Li · Adeola Olaitan · Aleksandra Gentry-Maharaj
Frontiers in Network Physiology
doi 10.3389/fnetp.2026.1799486
Review
Published
Vector-amplified toxicity of microplastics and heavy metals in aquatic invertebrates: mechanistic insights and implications for sustainable aquaculture
Jaynos R. Cortes · John Lloyd F. Penionez · Jay D. Tering · Fabio C. Ruaza
Frontiers in Aquaculture
doi 10.3389/faquc.2026.1841755
Original Research
Published
Variability and longitudinal dynamics of donor-derived cell-free DNA in kidney and liver recipients: a comparison of absolute and relative quantities in plasma and urine
Fanny Sandberg · Nicholas Kueng · Vanessa Banz · Annalisa Berzigotti · Daniel Sidler · Carlo R. Largiadèr · Ursula Amstutz
Frontiers in Transplantation
doi 10.3389/frtra.2026.1790754
Original Research
Published
Decoding basal ganglia motor circuit dysfunction from handwriting: a physics-informed neural signal interpretation framework for Parkinson's disease screening
Krishnan Batri · S. Lakshmi · Salabat Khan · Zeshan Iqbal · Mohammad Alhefdi · Ghada Atteia · Sivaram Murugan
Frontiers in Neuroinformatics
doi 10.3389/fninf.2026.1814920
Brief Research Report
Published
The chronical outcome monitoring in dystonia with deep brain stimulation (COMEDD) study protocol: a longitudinal evaluation of chronic electrophysiological biomarkers in patients with dystonia and deep brain stimulation therapy
Lucia K. Feldmann · Jonathan Kaplan · Ana Luisa de Almeida Marcelino · Daniel Schulze · Andrea A. Kühn
Dystonia
doi 10.3389/dyst.2026.16304
Mini Review
Published
Fatigue relief is possible
M. De Ventura · G. Mattioni · T. L’Abbate · M. Bertoli · J. Grifoni · G. Persichilli · A. Canelli · A. D’Onofrio · L. Paulon · F. Tecchio
Frontiers in Integrative Neuroscience
doi 10.3389/fnint.2026.1822424
Editorial
Published
Editorial: Pathophysiology of diabetic kidney disease
Oscar Lorenzo
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1872162
Original Research
Published
Detection of bacterial and viral pneumonia in pediatric chest radiographs using fusion of mediastinum and lung imaging biomarkers
Sukanta Kumar Tulo · Shilpi Ruchi Kerketta · O. Rahul Manohar · Pramod Martha
Frontiers in Signal Processing
doi 10.3389/frsip.2026.1831207
Review
Published
ECM-targeted cancer interventions: nanobiotechnological paradigms for imaging and therapy
Trinayan Deka · Nayan Moni Choudhury · Nilay Kapinjal
Frontiers in Nanotechnology
doi 10.3389/fnano.2026.1742127
Systematic Review
Published
Environmental epigenetic modifiers in neurodegenerative diseases: a systematic review of epigenomic mechanisms and therapeutic targets
Pranay Wal · Sunita Mishra · Debashish Pradhan · Ankita Wal · Debashis Purohit · Lalit Mohan Nainwal · Vivek Dhir · Amin Gasmi
Frontiers in Epigenetics and Epigenomics
doi 10.3389/freae.2026.1833533
Review
Published
The interplay between bile acid metabolism and gut microbiome in biliary tract cancers
Ifeoma Ike · Farzad Teymouri · Christiana Crook · Sofia Guzman · Max Hazeltine · Dani Castillo · Daneng Li · Gagandeep Brar
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1774429
Review
Published
Research overview—2025: integrating scientific progress to accelerate global tuberculosis elimination
Patrick K. Moonan · Timothy H. Holtz
Frontiers in Tuberculosis
doi 10.3389/ftubr.2026.1805962
Original Research
Published
Blood biomarkers and atrial remodeling in patients at risk of atrial fibrillation
Filip Loncaric · Ilana Forado Benatar · Maria Mimbrero Guillamon · Loredana Nunno · Rafael Jimenez-Arjona · Laia Tirapu · Sílvia Montserrat · Laura Sanchis · Adelina Doltra · Bart Bijnens · Marta Sitges
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1801523
Original Research
Published
Structural brain lesions and action observation therapy outcomes in unilateral cerebral palsy: an exploratory study
Francy Cruz-Sanabria · Elena Beani · Valentina Menici · Silvia Filogna · Paolo Bosco · Simona Fiori · Laura Biagi · Giuseppina Sgandurra
Frontiers in Systems Neuroscience
doi 10.3389/fnsys.2026.1766684
Review
Published
Pathogenesis of diabetic cardiomyopathy and emerging therapeutic strategies: a network-based perspective
Haoqing Ren · Hengli Lai
Frontiers in Clinical Diabetes and Healthcare
doi 10.3389/fcdhc.2026.1823872