Advanced nanoplatforms for diagnosis and precision therapy in human diseases

Efficient diagnosis and precision therapy remain core challenges in biomedical science, particularly for complex and chronic diseases such as cancer, skin disorders, renal diseases, and neurodegenerative conditions including Parkinson’s disease. As global prevalence of these conditions continues to surge, there is a pressing need to develop robust strategies for early detection, accurate disease monitoring, and personalized therapy, which conventional approaches can seldom provide. Recent research has emphasized multifunctional nanoplatforms—especially metal-organic frameworks (MOFs), covalent-organic frameworks (COFs), and related organic polymeric systems—owing to their outstanding tunable porosity, high specific surface area, chemical modifiability, and biocompatibility. Significant advances have demonstrated that these framework-based nanomaterials can be rationally designed for site-specific drug delivery, real-time biosensing, synergistic (multi-modal) therapy, and sensitive biomarker detection, addressing critical gaps in modern disease management. Nonetheless, key obstacles remain, including biocompatibility, in vivo stability, scalable synthesis, and regulatory standards for clinical translation.This Research Topic aims to explore emerging strategies for the rational design, functionalization, and integration of advanced nanoplatforms—particularly MOFs, COFs, and hybrid frameworks—for the diagnosis, monitoring, and therapy of human diseases. Of special interest are cross-disciplinary approaches that merge nanotechnology with artificial intelligence (AI) and data-driven methodologies to optimize material selection, structure-performance relationships, and therapeutic efficacy. We invite investigations that advance the mechanistic understanding of nanoplatform-biological interactions, enable multi-modal (e.g., chemo-, photo-, and immuno-) therapies, and establish new paradigms for early disease recognition and personalized treatment. Additionally, we encourage submissions that critically assess translational hurdles, including large-scale production, biosafety, immune compatibility, and regulatory evaluation, as these are essential for transforming laboratory progress into clinical reality.This Research Topic covers both innovative research and comprehensive reviews in the field of nanomaterial-enabled diagnosis and therapy. The scope is limited to biomedical applications of framework and polymer-based nanoplatforms with clear relevance to translational or mechanistic biomedical science. To gather further insights and catalyze new advances, we welcome articles addressing, but not limited to, the following themes:o Rational design and synthesis of MOFs, COFs, and related nanoplatforms for biomedical applicationso Smart biosensors and real-time bioimaging for disease detection and monitoringo Targeted and controlled drug delivery, including stimulus-responsive and cell-specific systemso Multi-modal and synergistic therapies: chemo-, photodynamic, chemodynamic, combination, and immunotherapieso Artificial intelligence-assisted prediction, optimization, and synthesis of biomedical nanomaterialso Biocompatibility, immune response, and toxicological evaluation of nanoplatformso Challenges and solutions in clinical translation: biosafety, large-scale manufacturing, and regulatory pathwayso Advanced applications in specific diseases (e.g., cancer, inflammation, diabetes, renal disease, skin disease, neurodegenerative disorders)o Integration of natural products with framework-based nanomaterials for health and therapeutic innovationAppendix: We welcome original research articles, reviews, mini reviews, methods, and perspectives manuscripts. Topic editors: Jianqiang Liu, Deyun Ma, Yiyan Yu Source: https://www.frontiersin.org/research-topics/78262/advanced-nanoplatforms-for-diagnosis-and-precision-therapy-in-human-diseases