Advancements and Challenges in Xenotransplantation: Genetically Modified Pig Organs for Human Transplant

Xenotransplantation, involving organ transplants between species, offers a potential solution to the shortage of human donor organs. Advances in genetic engineering, particularly with genetically modified pigs, have brought the field closer to clinical use. However, challenges such as immunological rejection, ethical issues, and zoonotic infection risks persist. Landmark studies show promise, with successful trials in non-human primates and initial human cases. Ongoing debates focus on optimal genetic modifications, immunosuppressive regimens, and patient selection. Comprehensive ethical and regulatory frameworks are crucial for safe clinical translation. This research topic explores xenotransplantation's efficacy, safety, and ethical considerations, aiming to revolutionize transplantation medicine. Topic editors: Hirofumi Hirao, Shinichi Matsumoto Source: https://www.frontiersin.org/research-topics/76070/advancements-and-challenges-in-xenotransplantation-genetically-modified-pig-organs-for-human-transplant