Advances in Electrochemical Sensors and Biosensors for Biomedical Applications

Electrochemical biosensors are entering their seventh decade since their inception. Despite this long evolution process, technological progress in their development is only evident in glucose biosensors – so-called glucometers, which have been on the market for around four decades, however still demanding improvements.At the same time, emergency and personalized medicine has a pressing need for reliable, portable devices that can monitor vital clinical parameters, the state of the microbiome across different parts of the human body, and even the effects of various drug delivery systems with controlled release of the active ingredient. In this context, electrochemical sensors and biosensors have the potential to address these tasks due to their ability to be miniaturized and portable, and to provide convenience in working with electrical signals that can be easily digitized and transmitted as data. This research topic focuses on key challenges in electrochemical sensors and biosensors, such as enhancing sensitivity and portability. It also explores the use of nanotechnology—like various 2D (graphene, carbon nitrides, etc.) and 3D nanomaterials (noble metals nanostructures), semiconducting materials (e.g. transition metals oxides, sulphides, selenides, telurides), nanozymes, and more—to detect biologically important analytes at very low concentrations. Developments in wearable devices for continuous monitoring; combining electrochemical sensors with microfluidic systems or optical sensors; point-of-care (POC) testing; and AI-supported data analysis for rapid disease diagnosis, along with sensors that utilize biomimetic components as recognition elements and multianalyte sensing platforms, will be central themes of this special collection. Analytical methods to be employed might be amperometric, voltammetric or impedance techniques, used alone or in combination between them, as well as with UV-Vis spectrometry, fluorescence, Raman scattering or other optical method. Additionally, different strategies for stabilizing biorecognition components—such as enzymes, proteins, aptamers, antibodies, or cellular components—to achieve improved operational stability in biosensors will be particularly important. This research topic invites submissions within a relatively broad scope. The focus areas include improvements in design, stability, portability, sensitivity, and selectivity of electrochemical sensing devices with prospective applications in emergency or personalized medicine, such as, but not limited to: • Electrochemical sensors and biosensors for disease diagnostics;• Nanomaterials and technologies for fabricating sensors/biosensors with very low limits of detection;• Sensors/Biosensors for monitoring of hormones, neurotransmitters, pharmaceuticals or their metabolites;• Current trends in wearable and ingestible sensors/biosensors;• Biomimetic or bioinspired materials for sensing applications;• Sensing platforms with combined electrochemical and optical detection (fluorescence and Raman scattering), spectroelectrochemical and multianalyte sensing platforms and more. Topic editors: Nina D. Dimcheva, Totka Dodevska, Stasyuk Nataliya Source: https://www.frontiersin.org/research-topics/80549/advances-in-electrochemical-sensors-and-biosensors-for-biomedical-applications