Advances in Medical and Surgical Treatment Strategies of Pancreatic Cancer

Pancreatic cancer remains one of the most challenging malignancies in modern oncology, characterized by aggressive tumor biology, frequent presentation at an advanced stage, and limited long-term survival. Pancreatic ductal adenocarcinoma represents the predominant histological subtype and requires a multidisciplinary approach integrating surgery, systemic therapy, radiotherapy, molecular profiling, and supportive care. Although surgical resection remains the cornerstone of potentially curative treatment, only a proportion of patients are candidates for upfront surgery, emphasizing the importance of improved strategies for both localized and advanced disease.Recent advances are rapidly reshaping the management of pancreatic cancer. Minimally invasive and robotic pancreatic surgery, refinements in vascular resection and reconstruction, and improved perioperative pathways have expanded the boundaries of surgical treatment. At the same time, modern neoadjuvant and adjuvant regimens, novel systemic therapies, and evolving approaches to borderline resectable and locally advanced disease have created new opportunities for patient selection and conversion to resectability. Increasing understanding of tumor biology, molecular heterogeneity, biomarkers, and the tumor microenvironment is also facilitating the development of precision and personalized treatment strategies. Together, these developments highlight the need for continued multidisciplinary research aimed at optimizing treatment selection, improving oncological and perioperative outcomes, and ultimately enhancing survival and quality of life for patients with pancreatic cancer.The goal of this Research Topic is to provide a comprehensive and contemporary overview of emerging medical and surgical strategies for the management of pancreatic cancer. Despite substantial advances in surgical techniques, perioperative care, systemic therapy, and molecular oncology, pancreatic cancer continues to be associated with poor prognosis, highlighting the need for more effective and individualized treatment approaches. This Research Topic aims to bring together high-quality clinical, translational, and evidence-based research addressing innovations across the entire pancreatic cancer treatment pathway. Particular emphasis will be placed on advances in minimally invasive and robotic surgery, neoadjuvant and adjuvant treatment, management of borderline resectable and locally advanced disease, precision oncology, novel therapeutic targets, and multidisciplinary patient selection. Ultimately, this collection seeks to identify current progress, remaining challenges, and future directions that may improve oncological outcomes and patient care.We welcome Original Research, Systematic Reviews, Meta-analyses, Reviews, and other relevant article types addressing contemporary and emerging strategies in pancreatic cancer. Topics of interest include, but are not limited to:• Advances in pancreatic cancer surgery, including minimally invasive and robotic approaches, vascular resection and reconstruction, extended resections, and strategies for improving perioperative and oncological outcomes.• Neoadjuvant, adjuvant, and systemic treatment strategies, including chemotherapy, radiotherapy, immunotherapy, and emerging combination regimens.• Management of borderline resectable, locally advanced, recurrent, and metastatic pancreatic cancer, including conversion therapy and multidisciplinary patient selection.• Precision oncology and novel therapeutic approaches, including molecular profiling, clinically validated biomarkers, targeted therapies, and tumor microenvironment-directed strategies.• Innovations across the multidisciplinary treatment pathway, including patient selection, treatment sequencing, perioperative optimization, surveillance, recurrence management, and approaches aimed at improving survival and quality of life.Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal. Topic editors: Christos Damaskos, Zilvinas Dambrauskas, Anisse Tidjane Source: https://www.frontiersin.org/research-topics/85549/advances-in-medical-and-surgical-treatment-strategies-of-pancreatic-cancer