Advances in Neural Repair after Stroke: Mechanisms and Clinical Translation

Neural repair after stroke is a vital field focused on addressing persistent disability, which remains common despite progress in acute care. While acute treatments have improved survival and initial outcomes, many stroke survivors face long-term functional deficits due to gaps in repair strategies. Ongoing research has revealed important mechanisms—such as neuroplasticity, axonal sprouting, remyelination, neurogenesis, angiogenesis, and involvement of glial cells, inflammation, and the extracellular matrix—that drive recovery. Although these insights have suggested new avenues for therapy, effective clinical translation and integration of evolving interventions remain major challenges.This Research Topic aims to advance the understanding and application of neural repair mechanisms in post-stroke patients. We seek to bridge basic mechanistic discoveries with clinical trials and practical interventions, accelerating recovery and improving patient outcomes. The focus is on clarifying key processes, identifying effective treatments, and fostering collaboration among neuroscientists, clinicians, and rehabilitation experts.To gather further insights into post-stroke neural repair, this research topic welcomes studies within defined mechanistic and translational frameworks, without extending to unrelated neurological disorders. We invite submissions of original research and review articles. Topics of interest include, but are not limited to:• Mechanistic Insights: Neuroplasticity (structural and functional), axonal sprouting, remyelination, neurogenesis, angiogenesis, and the roles of glial cells, inflammation, and the extracellular matrix.• Advanced Interventions: Novel pharmacological agents, cell-based therapies, biomaterial scaffolds, neuromodulation techniques (e.g., tDCS, TMS), and brain-computer interfaces.• Clinical Translation: Design and outcomes of clinical trials for recovery-promoting therapies, biomarkers for predicting repair potential, and advanced neuroimaging techniques to monitor repair processes.• Rehabilitation Paradigms: Mechanism-informed rehabilitation strategies and their integration with biological interventions.This collection aims to synthesize cutting-edge knowledge, fostering interdisciplinary dialogue to accelerate the development of effective repair strategies and improve the lives of stroke survivors. Topic editors: Anjing Zhang, Shan Jiang, Vikas H M, Peile Liu Source: https://www.frontiersin.org/research-topics/82456/advances-in-neural-repair-after-stroke-mechanisms-and-clinical-translation