Autoimmune and immune-mediated forms of alopecia

The last decade has witnessed significant developments in the understanding of the pathogenesis of alopecia areata, as well as the emergence of drugs which have revolutionized its treatment. This has also led to a better understanding of risk factors and prognostic indicators.On the other hand, the etiology of virtually all types of primary cicatricial alopecia remains poorly understood. However, there have been a few advances (genetic and molecular) which have begun to shed light on their pathogenesis. Similarly, while treatments are still largely unsatisfactory, a broader range of agents are now available. Furthermore, the intersection between alopecia and systemic immune-mediated diseases is becoming increasingly recognized, revealing shared inflammatory pathways.A significant problem in current practice is the disparity in our understanding of different immune-mediated alopecias. While the elucidation of key inflammatory pathways in alopecia areata has led to targeted interventions, primary cicatricial alopecias remain an area with profound unmet clinical needs and a lack of specific, pathogenesis-driven therapies. Furthermore, the mechanisms driving alopecia in association with systemic immune-mediated diseases require further investigation. The goal of this Research Topic is to unite the latest research across this spectrum of autoimmune and immune-mediated hair loss. We aim to gather investigations into the cellular, genetic, and molecular landscapes of these disorders to better understand the immunological circuits driving follicular inflammation and fibrosis.Ultimately, this comprehensive understanding is essential for translating recent advances into clinical practice, identifying novel biomarkers, and establishing precise therapeutic targets.Themes suggested, but not limited to:- Pathobiology of autoimmune and immune-mediated types of alopecia- Alopecia in association with systemic immune-mediated diseases- Clinical and histopathological features, and associated co-morbidities- Treatments, including older and novel treatments targeting immunological featuresTypes of manuscripts considered:- Systematic reviews- Original articles- Narrative reviews- Mini reviews- Case reports and case seriesConflict of interest declared:No direct conflict related to the present Research Topic is identified.1. Dr. Maria Fernanda Gavazzoni Dias has received honoraria for lectures, advisory board participation, and/or consultancy from pharmaceutical and dermocosmetic companies (UnderSkin, Vichy, Pfizer, Ache pharmaceuticals). All activities are conducted in accordance with ethical and scientific standards. No direct conflict related to the present Research Topic is identified.2. MH has received speaker / consultancy fees from Abbvie, Pfizer, Eli Lilly, Legacy Healthcare and Sun Pharma; has received research grants from UCB and Pfizer; he is the CI/PI on clinical trials for Manentia, Abbvie, Sanofi, Priovant and Eli Lilly.3. Dr. Bevin Shareholder with Samson Clinical Advisory Board, L'Oreal Australia Topic editors: Bevin Bhoyrul, Maria Fernanda Reis Gavazzoni Dias, Poonkiat Suchonwanit, Matthew Harries Source: https://www.frontiersin.org/research-topics/80161/autoimmune-and-immune-mediated-forms-of-alopecia