Bacterial extracellular vesicles in host immunity, infection, and disease

Bacterial extracellular vesicles, including outer membrane vesicles from Gram negative bacteria and membrane vesicles from Gram positive bacteria, carry proteins, lipids, nucleic acids, and other biologically active cargo. They provide a means of communication between bacteria and host cells and can shape immune recognition, inflammatory responses, barrier function, and antimicrobial defense.This Research Topic will examine how bacterial extracellular vesicles influence host immunity across infection and non infectious disease settings. We welcome mechanistic studies of vesicle formation and cargo, host uptake and recognition, and the resulting effects on innate and adaptive immunity. Relevant contexts include acute and chronic infection, chronic inflammation, inflammatory bowel disease, cancer immunity, and systemic immune responses. Studies of commensal and pathogenic bacteria are welcome when they show a direct role for bacterial vesicles in a defined host immune process.The Topic will also consider translational studies of bacterial vesicles as biomarkers, vaccine platforms, or therapeutic tools when they test or apply a defined vesicle mediated immune mechanism. By centering on bacterial extracellular vesicles while spanning multiple immune responses and disease settings, the Topic aims to offer a clear scientific focus without limiting contributions to a single disease or branch of immunity.We welcome Original Research, Reviews, Mini Reviews, Brief Research Reports, and Perspectives on:-Formation, release, composition, and cargo selection of bacterial extracellular vesicles-Host cell uptake and recognition of vesicles from commensal and pathogenic bacteria-Effects on innate and adaptive immune responses, including inflammatory signaling, antigen presentation, and immune cell function-Vesicle effects on epithelial barriers, antimicrobial defense, immune tolerance, and host pathogen interactions-Bacterial vesicle mediated immune activation, suppression, or evasion in infection and disease-Mechanistic roles in chronic inflammation, inflammatory bowel disease, cancer immunity, and systemic immune responses-Vesicle based biomarkers, vaccines, and therapeutic strategies supported by a defined immune mechanismSubmissions should establish a direct and mechanistic link between bacterial extracellular vesicles and a host immune outcome. Purely descriptive microbiome profiling, studies of microbial metabolites without a vesicle connection, host derived vesicles without a bacterial vesicle component, clinical characterization without an immune mechanism, body weight regulation, organ injury without immunological analysis, and viral immunology are outside the scope. The topic editors declare no conflict of interest Topic editors: Fernando Gil, Frank Stassen Source: https://www.frontiersin.org/research-topics/86529/bacterial-extracellular-vesicles-in-host-immunity-infection-and-disease