Biopolymer Biomaterials for Tissue Engineering and Regenerative Medicine

Biopolymer-based biomaterials are central to tissue engineering and regenerative medicine, where material composition, crosslinking strategy, processing history, and fabrication route strongly influence biological and regenerative performance. Recent advances in hydrogels, porous matrices, nanofibrous systems, meshes, and composite biopolymer constructs have expanded the development of biomimetic platforms with controlled mechanics, porosity, swelling, transport, degradation, and interfacial properties. At the same time, reproducibility, sterilisation, storage stability, and ageing-related property drift remain important challenges for the robust use and pre-clinical translation of these systems. A clearer understanding of how biomaterial design and structure–property relationships affect cell behaviour, host–material interactions, matrix remodelling, and tissue-relevant outcomes is therefore essential. This Research Topic focuses on biopolymer biomaterials for tissue engineering and regenerative medicine that combine rigorous physicochemical characterization with mechanistically informed biological validation in relevant in vitro, ex vivo, and in vivo models.This Research Topic aims to bring together original and review-based contributions that advance crosslinked biopolymer biomaterials as experimentally rigorous platforms for regenerative applications. We welcome studies that connect material design, processing, and structure–property relationships, including chemistry, crosslink density, morphology, porosity, mechanics, swelling, transport, degradation, surface properties, and biointerface behaviour, to biological and functional outcomes. Particular interest is given to natural and semi-synthetic biopolymers, including collagen-, gelatin-, hyaluronic-acid-, and silk-based matrices, as well as biopolymer-based composite materials and bioactive hybrid systems. We also encourage submissions on fabrication approaches, including 3D printing, electrospinning, controlled-porosity methods, and textile- or mesh-like biopolymer constructs, particularly where these improve reproducibility, manufacturability, architecture, or cell–material interactions. By linking biomaterial design, processing, sterilisation, stability, and degradation to mechanistically informed biological validation, this Research Topic seeks to support rigorous pre-clinical research on material-guided cellular responses, tissue formation, matrix remodelling, and regenerative function.Suitable submissions include Original Research Articles, Reviews, Mini-Reviews, and Methodological Articles. Topics in scope include crosslinked hydrogels, porous biopolymer matrices, nanofibrous meshes, surface-modified biomaterials, biopolymer-based composites, processing–structure control, sterilisation and storage effects, ageing-related property drift, and degradation kinetics linked to microstructure and performance. Studies should include appropriate in vitro, ex vivo, and/or in vivo validation, such as cytocompatibility, cell adhesion, viability, proliferation, migration, morphology, immune-relevant screening, host–material interaction, and mechanistically informed evaluation linking biological outcomes to defined material properties and regenerative objectives. This Research Topic is strictly non-clinical: clinical studies, patient data, case reports, and clinical trials are out of scope. Purely computational or data-mining studies must include appropriate experimental validation. Topic editors: István Hornyák, Srinivas Madduri, Mariana Cid, Dóra Tátraaljai Source: https://www.frontiersin.org/research-topics/79160/biopolymer-biomaterials-for-tissue-engineering-and-regenerative-medicine