Bridging Mechanisms and Practice: Translational and Clinical Research in Wound Healing and Fibrotic Skin Diseases

Wound healing is a tightly regulated process involving hemostasis, inflammation, proliferation, and remodeling. Disruptions in these phases can lead to chronic non-healing wounds or excessive scarring, both of which pose significant clinical and socioeconomic burdens worldwide.Advances in molecular biology, pharmacology, and tissue engineering have expanded our understanding of the mechanisms governing tissue repair. Emerging approaches such as stem cell therapies, biomaterial-based scaffolds, and targeted drug delivery systems have shown promise in enhancing healing outcomes.Despite significant advances in basic research, the translation of these findings into effective clinical therapies remains a major challenge, particularly in the management of chronic wounds and pathological scarring conditions such as keloids and fibrotic skin diseases.The primary goal of this Research Topic is to address the persistent gap between experimental discoveries and their clinical implementation in wound healing. While substantial progress has been made in understanding the molecular and cellular mechanisms underlying tissue repair, many promising findings fail to translate into effective therapies for patients, particularly those suffering from chronic wounds or pathological scarring.By bringing together basic scientists, clinicians, and bioengineers, the Topic aims to identify actionable therapeutic targets, validate novel treatment approaches, and improve the design of clinically relevant interventions. In addition, this collection seeks to highlight emerging insights into wound-healing–related disorders, including hypertrophic scars, keloids, and fibrotic skin diseases, with an emphasis on identifying novel molecular targets and therapeutic interventions.This Research Topic welcomes submissions covering a broad range of themes related to translational wound healing research. Topics of interest include, but are not limited to: molecular and cellular mechanisms of tissue repair; pharmacological modulation of wound healing; stem cell and regenerative medicine approaches; biomaterials and tissue-engineered constructs; advanced drug delivery systems; and clinical strategies for managing acute and chronic wounds. We also encourage studies focusing on wound-healing–related disorders, including keloids, hypertrophic scars, and fibrotic skin diseases, particularly those identifying novel therapeutic targets or interventions. We encourage submissions from diverse disciplines, including pharmacology, bioengineering, dermatology, molecular biology, and clinical medicine. By fostering collaboration across these fields, this Research Topic aims to accelerate the development of effective, evidence-based strategies to improve patient outcomes in both acute and chronic wound care. Authors are invited to submit Original Research articles, SHort Research Reports, Reviews, Mini-Reviews, Systematic Reviews, Methods Articles and Case Reports. Topic editors: Alessia Paganelli, Agata Janowska Source: https://www.frontiersin.org/research-topics/80012/bridging-mechanisms-and-practice-translational-and-clinical-research-in-wound-healing-and-fibrotic-skin-diseases