Bridging Metabolic Dysfunction: Unified Mechanisms and Interventions Across Cardiovascular, Cancer, and Gastrointestinal Diseases

Cardiometabolic research has increasingly recognized the centrality of metabolic dysregulation and dietary imbalances in the development and progression of multiple chronic diseases. Evidence now highlights that excessive caloric intake, poor dietary patterns, and metabolic syndrome are interconnected risk factors not only for cardiovascular diseases, but also for cancer and gastrointestinal disorders. Shared mechanisms, particularly chronic inflammation and immune dysfunction along the nutrition–metabolism–immune axis, fuel these interconnected conditions. While targeted therapies for one disease domain may inadvertently disrupt metabolic homeostasis or trigger complications in another, studies indicate that addressing these common metabolic pathways can offer broad preventative and therapeutic benefits. However, there remain critical knowledge gaps in understanding the precise molecular interrelations, the translational impact of new therapies on clinical outcomes, and the safest ways to integrate nutrition-focused strategies across disease domains.This Research Topic aims to elucidate the pathophysiological intersections and therapeutic opportunities at the interface of nutrition, metabolism, and cardiovascular health, particularly as they relate to concurrent cancer and gastrointestinal diseases. We seek to explore how shared metabolic risk factors such as central obesity, dyslipidemia, and hyperglycemia drive overlapping pathogenic processes, and to clarify the outcomes of targeting metabolism—via pharmacological or dietary interventions—across these disease states. Key objectives include identifying common biomarkers, understanding the dual impacts of therapies (such as SGLT-2 inhibitors), and advancing integrated, cross-disciplinary treatment models. In particular, we encourage exploration into how cardiovascular metabolic pathways both influence, and are influenced by, cancer and gastrointestinal conditions, and how this knowledge can minimize adverse effects and maximize patient benefit.The scope of this Research Topic is focused on mechanistic and translational studies situated at the crossroads of cardiovascular metabolism, cancer, and gastrointestinal diseases. Submissions must explicitly address cardiovascular involvement as a central component. We invite Original Research and comprehensive Review articles that investigate shared or intersecting pathogenic mechanisms, preventive or therapeutic interventions, and biomarkers relevant to at least two of these disease categories.To gather further insights in this area, we welcome articles addressing, but not limited to, the following themes:• Metabolic crosstalk and inflammatory pathways in cardiovascular, cancer, and gastrointestinal diseases• Shared nutritional risk factors and preventive dietary strategies• Common metabolic or inflammatory biomarkers across disease domains• Pharmacological and dietary interventions that modulate cardiometabolic pathways relevant to multiple diseases• Management of cardiovascular complications from cancer therapies in the context of metabolic dysfunction• Role of gut microbiota and prebiotics in modulating systemic metabolism and cardiovascular health• Translation of emerging cardio-oncology metabolic therapies to clinical practice• Mechanistic studies on the progression from metabolic dysfunction to multisystem diseaseAppendix: We consider both Original Research articles and Reviews, including preclinical, translational, or clinical investigations that fulfill these objectives. Topic editors: Yichuan Jiang, Yan Li, Gobinath Shanmugam Source: https://www.frontiersin.org/research-topics/78115/bridging-metabolic-dysfunction-unified-mechanisms-and-interventions-across-cardiovascular-cancer-and-gastrointestinal-diseases