Cancer Cell Mechanobiology: Spatiotemporal Mechanotransduction and Nucleocytoplasmic Transport

Mechanical cues in tumors, such as matrix stiffness, shear stress, stretch, and loss of cell–cell tension, shape cancer cell function by altering cell structure and mechanotransduction signaling. This Research Topic will feature mechanistic and quantitative studies on cancer cell mechanobiology, with emphasis on spatiotemporal signaling linking the membrane and cytoskeleton to nuclear responses, polarity, and directed migration. We particularly welcome work combining controlled mechanical perturbations, live-cell imaging, and computational/modeling approaches to connect physical inputs to defined cellular outcomes. Themes of interest include, but are not limited to, the following areas:• Mechanosensitive signaling and nuclear transport (e.g., YAP/TAZ, PTEN, importins)• Cytoskeletal remodeling, polarity, and collective/directed migration• Matrix mechanics and engineered microenvironments (e.g., stiffness, confinement, microtopography)• Quantitative imaging and mechanistic modeling of mechanotransduction dynamics Topic editors: Susumu Kudo, Shinji Deguchi, Cristina Bertocchi Source: https://www.frontiersin.org/research-topics/78334/cancer-cell-mechanobiology-spatiotemporal-mechanotransduction-and-nucleocytoplasmic-transport