Case Reports in Tumor Genomics and ctDNA in Precision Medicine - Volume II

This Research Topic is the second volume of the Research Topic Case Reports in Tumor Genomics and ctDNA in Precision MedicineThe study of tumor genomics and circulating tumor DNA (ctDNA) has revolutionized the field of cancer research, diagnosis, and treatment. A significant challenge within this domain is the identification and interpretation of genetic variations known as variants of unknown significance (VUS). These variants, often encountered in tumor samples or ctDNA, present a conundrum as their clinical implications remain uncertain, complicating patient care. VUS may manifest as single-nucleotide changes, insertions, deletions, or complex genetic rearrangements, and their understanding is crucial for determining appropriate treatment strategies. Recent studies have highlighted the potential impact of these variants on disease prognosis, therapy response, and hereditary cancer risk assessment. Despite ongoing large-scale collaborations and functional studies aimed at deciphering these mutations, a comprehensive understanding remains elusive. Researchers are increasingly integrating multi-omics data, such as gene expression profiles, to enhance the interpretation of VUS and their potential impact on tumor biology. However, there remains a pressing need for more precise and personalized management strategies for patients with these genetic profiles.This Research Topic aims to explore the clinical significance of variants of unknown significance in tumor genomics and ctDNA, with the ultimate goal of optimizing patient care and advancing precision oncology. By focusing on case reports, the research seeks to unravel the complexities of these genetic alterations and their implications for disease prognosis, therapy response, and hereditary cancer risk. The objective is to provide insights that will facilitate the development of personalized treatment strategies and improve outcomes for cancer patients.To gather further insights in the realm of tumor genomics and ctDNA, we welcome Case Report submissions addressing, but not limited to, the following themes:• Interpretation and classification of variants of unknown significance (VUS).• Impact of VUS on disease prognosis and therapy response.• Integration of multi-omics data for enhanced VUS interpretation.• Case studies highlighting personalized treatment strategies based on VUS.• Genetic counseling and risk assessment for patients with VUS.• Advances in genomic analyses and functional studies for VUS interpretation.• Collaborative efforts and large-scale studies in tumor genomics and ctDNA. Topic editors: Alice Chen, Li Chen Source: https://www.frontiersin.org/research-topics/75315/case-reports-in-tumor-genomics-and-ctdna-in-precision-medicine---volume-ii