Cell Cycle and Genome Instability: Implications for Cancer Evolution

Genome instability, from subtle mutations to extensive chromosomal rearrangements, is a defining hallmark of cancer and a driving force in tumor evolution. The dynamic landscape of chromatin structure directly impacts DNA repair processes, replication fidelity, and chromosomal segregation, key factors in the initiation and progression of many malignancies. Advances in chromosome and chromatin biology are revealing new mechanisms linking nuclear organization, genome maintenance, and cancer cell adaptability. Understanding these connections is essential for uncovering innovative therapeutic opportunities in oncology.This Research Topic seeks cutting-edge research, (mini)reviews, methods, perspective and more addressing molecular, structural, and functional aspects of genome instability relevant to chromatin and cancer biology. Submissions utilizing molecular, genomic, and imaging approaches are especially encouraged, as are interdisciplinary studies.Themes of interest might include, but are not limited to:o Chromatin architecture and its role in shaping genome stability and DNA repairo Replication stress and mechanisms fostering chromosomal instability in cancer cellso Epigenetic regulation of genome maintenance pathwayso Mitotic errors, aneuploidy, polyploidy, and large-scale chromosomal events in tumorigenesiso Cell cycle checkpoints, deregulation, and their contribution to genome instabilityo Therapeutic approaches targeting genome instability and chromatin-modifying factors Topic editors: Federica Scotto di Carlo, Fernando Gianfrancesco, Emenike K Onyido Source: https://www.frontiersin.org/research-topics/74673/cell-cycle-and-genome-instability-implications-for-cancer-evolution