Cellular and Physiological Responses to Stressors

This Research Topic focuses on how different stressors affect cells, tissues, and overall physiology. Stress can trigger oxidative damage, inflammation, metabolic changes, and impact tissue function. Understanding these responses is essential to improving health, resilience, and recovery. We welcome studies that explore how the body and cells respond to stress at the molecular, cellular, or systemic level, including responses to exercise as a controlled physiological stressor analyzed through Network Physiology approaches. Submissions may include experimental research, clinical studies, animal or cell models, and reviews. Work that sheds light on the mechanisms of stress responses or connects basic biology with practical applications is particularly encouraged.The goal of this Research Topic is to bring together studies that explore how various stressors impact cellular and systemic physiology from a Network Physiology approach. Stressors can trigger adaptive responses or, in some cases, cause tissue and cellular damage through oxidative stress, inflammation, or metabolic disruption. By examining these processes across different models and systems, researchers can gain a clearer understanding of the mechanisms that regulate resilience, tissue function, and overall health. Contributions that integrate molecular, cellular, and physiological data, or that investigate practical applications, are particularly encouraged. The aim is to highlight both fundamental mechanisms and translational insights, connecting basic research with potential strategies to improve health, prevent tissue damage, and enhance recovery in response to environmental or physiological challenges, including insights from exercise as a model of systemic stress using Network Physiology frameworks.Cells and tissues are constantly exposed to stress from environmental, metabolic, or physiological sources. These stressors can disrupt homeostasis, leading to oxidative stress, inflammation, and changes in metabolism. Understanding these responses is crucial for maintaining tissue function, health, and resilience. Biomarkers such as cytokines, reactive oxygen species, and metabolic intermediates provide valuable insights into cellular and systemic reactions to stress. Integrating molecular, cellular, and physiological measurements allows researchers to study how the body adapts or fails to adapt, informing strategies to prevent damage, support recovery, and improve overall health outcomes. Insights from such studies have broad relevance across physiology, toxicology, and clinical research, particularly when exercise is used as a controlled systemic stressor to probe network-level interactions.This Research Topic invites manuscripts that investigate cellular, molecular, and systemic responses to stressors. Topics of interest include:&#8226 Oxidative stress and antioxidant defenses&#8226 Immune responses and inflammation&#8226 Metabolic adaptations and tissue resilience&#8226 Cellular signaling pathways triggered by stress&#8226 Integration of molecular biomarkers with physiological or clinical dataWe welcome original research, reviews, perspectives, or methodological studies. Submissions from human, animal, or in vitro models are all suitable. Contributions providing mechanistic insights, comparative analyses, or translational applications are particularly encouraged. The goal is to connect fundamental research with practical outcomes in health, disease prevention, and clinical or applied physiology, with particular interest in studies using exercise as a physiological stressor analyzed through Network Physiology approaches. Topic editors: Martin Vojtek, Ana Reis-Mendes, Monika Majirska Source: https://www.frontiersin.org/research-topics/78864/cellular-and-physiological-responses-to-stressors