Cellular players in the pathogenesis of allergic rhinitis: an immunological update

Allergic rhinitis is an allergic condition characterized by sneezing, rhinorrhea, and nasal obstruction that can markedly impair quality of life. Seasonal and perennial patterns are often observed, reflecting differences in predominant allergen exposures. Pharmacotherapy and allergen immunotherapy can alleviate symptoms, and allergen avoidance, along with lifestyle modifications, are usually recommended; however, disease control remains inadequate in many patients.The nasal mucosa harbors diverse immune cell populations that collectively contribute to complex local inflammatory responses. A deeper understanding of how immune cells contribute to the onset, progression, and chronicity of allergic rhinitis is therefore essential to further refine current disease concepts and to guide the development of novel therapeutic strategies.Recent advances in immunology increasingly show that immune cell populations exhibit functional diversity, context-dependent behavior, and dynamic interactions. Such features cannot be fully captured by fixed or simplified paradigms. Both well-characterized and previously underappreciated immune cells may play stage-specific or multifaceted roles during disease initiation, progression, and chronicity within the nasal mucosa.The goal of this Research Topic is to consolidate recent experimental and conceptual advances that deepen our understanding of immune cell behavior in allergic rhinitis from an updated perspective. By bringing together studies that revisit well-established immune cell functions alongside those uncovering novel or unconventional roles, this Topic aims to refine existing concepts of disease development. Ultimately, this collection aims to provide an immunological framework that better reflects the cellular diversity and complexity of allergic rhinitis.This Research Topic focuses on the roles of immune cells in the pathogenesis of allergic rhinitis, with particular emphasis on cellular function, interactions, and heterogeneity within the nasal mucosa.Original research articles and reviews examining both well-established and emerging immune cell populations involved in allergic inflammation are welcome without presupposing specific immunological frameworks or classifications. Studies addressing how immune cells contribute to disease initiation, amplification, and chronicity are particularly encouraged.Topics of interest include immune cell–cell communication, spatial organization within nasal tissues, temporal dynamics during disease progression, immune memory, and functional diversity among immune cell populations. Contributions that provide conceptual or mechanistic insights into immune cell behavior in allergic rhinitis, based on experimental or analytical approaches, are within the scope of this Research Topic. Topic editors: Daisuke NAGAKUBO, Davor Plavec Source: https://www.frontiersin.org/research-topics/76794/cellular-players-in-the-pathogenesis-of-allergic-rhinitis-an-immunological-update