Chronic Kidney Allograft Diseases: New insight into pathogenesis and novel therapeutic targets

Kidney transplantation represents a significant advancement for managing end-stage renal disease (ESRD), offering improved recipient quality of life and financial benefits over sustained dialysis treatments. Key developments have been made in understanding transplantation immunity and enhancing surgical techniques, leading to standard immunosuppressive therapies. Despite these advancements, long-term allograft survival remains a challenge, with over 50% of recipients experiencing function loss after ten years. Chronic antibody-mediated rejection (CAMR) is a major factor in late allograft failure, exacerbated by multiple immunological and non-immunological factors, including high HLA sensitization, under-immunosuppression, and comorbid conditions like hypertension and post-transplant diabetes.This Research Topic aims to assess and synthesize comprehensive insights related to kidney transplant outcomes, addressing critical gaps in the management of chronic allograft dysfunction. It seeks to explore various aspects such as the efficacy of current treatments for CAMR, the development of novel diagnostic tools, and the effectiveness of personalized medicine approaches in improving long-term transplant survival.To gather further insights within the confines of kidney allograft longevity and complications, we welcome articles addressing, but not limited to, the following themes:The role of biomarkers in detecting early signs of chronic allograft damage.Impact of "omics" technologies and artificial intelligence on transplant outcomes.Strategies for improving treatment adherence and reducing immunosuppression-related side effects.Development and validation of non-invasive diagnostic methods.Interdisciplinary approaches for integrating novel research findings into clinical practice.Through these contributions, we aim to foster a deeper understanding of the pathophysiological complexities and advance clinical practices to enhance kidney transplant longevity. Topic editors: Francesca Leone, Michele Provenzano, Cristina Silvestre Source: https://www.frontiersin.org/research-topics/68607/chronic-kidney-allograft-diseases-new-insight-into-pathogenesis-and-novel-therapeutic-targets