Clinical Diagnostics and Immunological Profiling of Post-Infectious Sequelae Beyond SARS-CoV-2

Post-infectious sequelae—such as Post-Treatment Lyme Disease Syndrome, chronic post-viral fatigue, and post-bacterial autoimmune syndromes—present significant clinical challenges. Diagnosing and managing these conditions remains difficult due to a lack of standardized diagnostic criteria, validated biomarkers, and clinical tracking tools.This Research Topic focuses on the development, validation, and clinical utility of novel diagnostics and immunological profiling techniques for post-infectious sequelae. We invite submissions that advance the detection, risk stratification, and monitoring of chronic post-acute infectious syndromes. Studies must address the underlying clinical microbiology or immunology of human diseases. We particularly welcome research on the diagnostic utility of serological testing, autoantibody detection, and clinical biomarkers. Purely epidemiological or basic mechanistic studies without clinical diagnostic translation are out of scope for this collection.We welcome articles addressing, but not limited to, the following themes:-Novel Diagnostic Assays: Development and validation of molecular, serological, and immunological tests to identify and monitor post-infectious conditions.-Biomarker Discovery: Identification and clinical utility of soluble inflammatory mediators, cytokines, and cellular markers to risk-stratify post-acute syndromes.-Autoantibody and Serological Profiling: Testing for autoantibodies, neuroautoantibodies, and host immune markers triggered by persistent or resolved viral, bacterial, or parasitic infections.-Persistent Antigen Detection: Advanced diagnostic methods for identifying low-level microbial persistence or chronic antigen reservoirs in post-acute phases.-Immunological Monitoring: Tracking patient immune responses and cellular profiles during therapeutic or immunomodulatory interventions.-Prophylactic Evaluation: Clinical utility of preventive measures, including vaccines, in reducing the risk or development of long-term post-infectious sequelae. Topic editors: Juan Sebastian Izquierdo-Condoy, Esteban Ortiz-Prado, Manuel Colomé-Hidalgo Source: https://www.frontiersin.org/research-topics/82341/clinical-diagnostics-and-immunological-profiling-of-post-infectious-sequelae-beyond-sars-cov-2