Computational Biomechanics of Bone: Modeling, Simulation, and Validation

Bone is a complex biomaterial that consists of a hierarchical structure with heterogeneous and anisotropic mechanical behavior. Its mechanical properties vary with anatomical location, tissue composition, microstructure, and loading direction, particularly in cortical bone. These variations influence how bone deforms, accumulates damage, and ultimately fails under different loading conditions. Computational biomechanics provides valuable tools to investigate these complex behavior through constitutive modelling, finite element analysis, multiscale approaches, and image-based simulations. However, accurately representing the spatial and directional variations of bone properties remains a major challenge. The reliability of computational predictions also depends on appropriate experimental validation. Integrating computational modelling with mechanical testing, imaging, and other experimental techniques can therefore provide a more realistic understanding of bone tissue mechanics and improve the predictive capability of computational models.Accurately predicting the mechanical behaviour of bone remains challenging due to its complex and heterogeneous structure, anisotropic nature, and dependence on anatomical location and loading direction. Variations in tissue composition and microstructure can lead to significant differences in mechanical properties and failure behaviour, which are often difficult to measure using simplified computational models. In addition, many existing computational studies lack sufficient experimental validation, limiting the reliability and applicability of their predictions. This Research Topic aims to address these challenges by promoting advanced computational approaches that can more realistically represent the mechanical behaviour of bone tissue. Particular emphasis will be placed on models that account for spatial and orientation-dependent properties, elastic, viscoelastic, and elastic-plastic behaviour, damage evolution, and fracture. Experimental validation through mechanical testing, imaging, or other appropriate evidence will be an essential component of the studies. The overall goal is to develop reliable and validated computational frameworks that improve the understanding and prediction of bone tissue behaviour under different anatomical and loading conditions.This Research Topic focuses on the computational modelling, simulation, and experimental validation of bone tissue mechanics, with particular emphasis on the heterogeneous and anisotropic behaviour of bone. Key themes include spatial and anatomical variations in bone properties; orientation-dependent mechanical behaviour; elastic, viscoelastic, and elastic-plastic responses; and the mechanisms of damage initiation, evolution, fracture, and failure. Contributions employing finite element analysis, multiscale modelling, image-based modelling, constitutive modelling, and data-driven approaches are encouraged. Computational models must be appropriately validated against experimental evidence, including mechanical testing, imaging, or other relevant measurements. Contributions that integrate computational predictions with experimental characterization and advance the understanding and prediction of bone tissue mechanics are particularly encouraged. Studies focused primarily on implants, fixation devices, prostheses, or implant-bone systems are outside the scope unless the primary emphasis is on the underlying mechanics and behavior of bone tissue. Topic editors: Sachin Kalsi, Gaurav Arora, Jagjit Singh Source: https://www.frontiersin.org/research-topics/84887/computational-biomechanics-of-bone-modeling-simulation-and-validation