Critical Complications In Pediatric Oncology and Hematopoietic Cell Transplant - Volume IV

Given the success of Volume I, Volume II, and Volume III of this Research Topic, and how rapid the subject area is evolving, we are pleased to announce the launch of Critical Complications In Pediatric Oncology and Hematopoietic Cell Transplant - Volume IV.In pediatric oncology, timely and sophisticated medical management is crucial, especially for those undergoing hematopoietic cell transplant (HCT), who face severe onco-critical complications. Approximately 25-33% of pediatric cancer patients will find themselves in the Pediatric Intensive Care Unit (PICU) at some phase during treatment. Collaboration among specialists is vital to address the uniquely severe presentations, diagnostics, and treatment tactics these young patients require. Notably, recent studies have highlighted alarming rates of conditions like sepsis, respiratory complications, and multi-organ failure in this cohort, showcasing an acute need for focused medical attention.This Research Topic strives to unveil new findings and foster debate within the nascent specialty of pediatric onco-critical care. The objective is to explore and disseminate knowledge regarding the pathophysiological nuances, diagnostic methods, therapeutic interventions, and prognostic outcomes involved in the management of HCT and oncology patients who develop critical illnesses. Engaging with Original Research and Review articles will provide a multifaceted viewpoint on the dynamic complexities these young patients encounter.The scope of Volume IV is defined by a commitment to investigating crucial patient health variables within pediatric onco-critical care. Contributors, including members of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network but not limited to, will examine areas such as:- The impact of endothelial dysfunction.- Management and outcomes of respiratory complications.- Implications of thrombotic disorders like thrombotic microangiopathy and veno-occlusive disease.- Effectiveness of CAR T-Cell therapy and its complications.- Challenges in managing organ failure, sepsis, and infectious diseases.- Additionally, the topic will delve into socioeconomic and healthcare disparities illustrated by resource-limited setting outcomes and the benefits of global healthcare partnerships.Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.Dr. Melissa Hines declares having served as a consultant for Novartis and SOBI, and having received research funding from Incyte.Dr. Kris Mahadeo declares having served as a consultant and speaker for SOBI, and having received investigator-initiated trial (IIT) funding from SOBI, Jazz Pharmaceuticals, and Novartis. He also declares having served on an advisory board for Gamida Cell.Dr. Dristhi Ragoonanan and Dr. Jennifer McArthur declare no conflicts of interest in relation to this Research Topic. Topic editors: Jennifer Ann McArthur, Kris Michael Mahadeo, Dristhi Ragoonanan, Melissa R Hines Source: https://www.frontiersin.org/research-topics/86103/critical-complications-in-pediatric-oncology-and-hematopoietic-cell-transplant---volume-iv