Deciphering host-virus interactions and advancing therapeutics for chronic viral infection: Volume II

Chronic viral infections like HIV and HBV pose significant threats to human health, leading to substantial mortality and ongoing new infections each year. Despite advancements, our understanding of virus-host immune interactions, inflammatory pathogenic mechanisms, and disease progression remain incomplete.This research topic extensively investigates the intricate interactions between chronic viral infections and the host immune system and aims to uncover how abnormal immune activation-induced inflammation or immune exhaustion impairs effective antiviral responses and seeks to elucidate the underlying mechanisms of chronic viral infections by exploring the causal relationships between pathogenesis and disease progression. Specifically, it focuses on clarifying the roles of specific immune cells and pathways involved in these processes. Emphasis is placed on understanding the viral infection route, immune metabolic mechanisms, pro-inflammatory pathways, cell death processes, and the complex responses of T and B cells, particularly virus-specific T and B cell responses. Ultimately, this research aims to pioneer innovative therapeutic strategies for the effective management and potential cure of chronic viral diseases like AIDS and chronic HBV. Through this exploration, the goal is to deepen our understanding of the host immune response to chronic viral infections, particularly AIDS and CHB, paving the way for new interventions that could mitigate the profound global health impact of these infections.1. Regulatory Mechanisms of Cellular Immune Metabolism during Viral Infection (e.g., HIV, HBV, etc.): how immune cell metabolism, including processes like glycolysis and mitochondrial metabolism, is regulated and how these mechanisms contribute to the immune system's antiviral defenses. It focuses on understanding the metabolic pathways and signals that influence immune cell functionality in combating viral infections.2. Pathogenic Mechanisms of Viral-Induced Inflammation: explore how viral infections, particularly HIV and HBV, induce tissue inflammation and pathological damage. It aims to identify the molecular and cellular pathways that trigger the inflammatory response, elucidating their roles in tissue injury and disease progression.3. Innovative Therapeutic Strategies for AIDS and CHB: new therapeutic approaches geared towards achieving functional cures for AIDS and Chronic Hepatitis B (CHB). It includes investigating novel treatments such as immunotherapies (e.g., anti-PD-1, anti-PD-L1 therapies), personalized vaccine strategies, gene and cell therapies, and combination therapies.This Research Topic is the second volume of the Deciphering host-virus interactions and advancing therapeutics for chronic viral infection. Please see the first volume here. Topic editors: Qian Li, Jean-Pierre Routy Source: https://www.frontiersin.org/research-topics/82944/deciphering-host-virus-interactions-and-advancing-therapeutics-for-chronic-viral-infection-volume-ii