Decoding Adult Primary Brain Tumors: New Frontiers in Neuro-Oncology

Primary brain tumors represent a formidable field within neuro-oncology, marked by profound challenges due to their biological complexity and devastating clinical consequences. These tumors exhibit substantial heterogeneity at the genetic, epigenetic, and cellular levels, which complicates diagnostic precision, prognostication, and treatment efficacy. Recent technological advances, such as multi-omics profiling, high-resolution imaging modalities, and artificial intelligence methods, have unraveled new dimensions of tumor biology, highlighting the intricacy of oncogenic pathways, immune-evasive strategies, and the dynamic tumor microenvironment. The identification of novel molecular subtypes and the shift toward integrated histo-molecular classifications have begun to inform more nuanced approaches to diagnosis and disease stratification, especially within the adult population. Nevertheless, translating these scientific discoveries into impactful clinical applications remains a major unmet challenge, underscoring the necessity for integrative, multidisciplinary strategies that close the gap between bench and bedside.This Research Topic aims to catalyze innovation in the understanding and management of primary brain tumors through the convergence of multidisciplinary expertise and state-of-the-art technologies. By uniting the efforts of molecular biologists, clinicians, neurosurgeons, radiologists, pathologists, and data scientists, the initiative seeks to accelerate the development of validated biomarkers, actionable molecular signatures, and precision-targeted therapies. Key objectives include the integration of artificial intelligence and advanced neuroimaging into day-to-day clinical practice, a deeper exploration of adult tumor subtypes, and the identification of novel predictive and prognostic indicators. Central questions addressed will concern the mechanisms behind therapy resistance and recurrence, strategies for disease stratification, innovative approaches to therapeutic delivery, and ultimately, interventions that tangibly improve patient outcomes.The scope of this Research Topic is firmly rooted in translational and clinical research, spanning the spectrum from discovery science to real-world application, with a strong emphasis on interdisciplinary perspectives and comparative analyses primarily focused on adult neuro-oncology. To gather further insights into the landscape of primary brain tumors, we welcome articles addressing, but not limited to, the following themes:- Multi-omics and single-cell analyses highlighting tumor evolution and heterogeneity.- Integration of molecular profiling into CNS tumor classification systems.- Comparative studies of molecular and clinical features in adult primary brain tumors.- Discovery and validation of diagnostic and prognostic biomarkers, including emerging liquid biopsy techniques.- Novel advances in neuroimaging, radiogenomics, and patient monitoring technologies.- Biological and molecular mechanisms underlying therapeutic resistance and disease recurrence.- Development and evaluation of immunotherapeutic and targeted approaches.- Investigation of the tumor microenvironment and immune modulation strategies.- Application of artificial intelligence and computational modeling in translational neuro-oncology research.- Innovation in therapeutic delivery, surgical techniques, and management paradigms.- Presentation of unique clinical or biological case studies with broader implications.Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope of this Research Topic. Topic editors: Antonio Meola, Alessia Pellerino Source: https://www.frontiersin.org/research-topics/77495/decoding-adult-primary-brain-tumors-new-frontiers-in-neuro-oncology