Delivery Systems and Formulation Strategies for Chronic Dermatitis and Skin Aging

Chronic inflammatory skin disorders such as atopic dermatitis, psoriasis, and eczema, together with intrinsic and extrinsic skin aging, represent major clinical and societal challenges. These conditions are characterized by complex pathophysiological mechanisms including persistent inflammation, oxidative stress, immune dysregulation, and alterations of the skin barrier. Collectively, these processes contribute to impaired skin function, reduced quality of life, and increasing healthcare demands.Topical and dermal therapies remain the cornerstone of treatment for many dermatological conditions. However, their therapeutic effectiveness is frequently limited by the barrier properties of the skin, insufficient local drug availability, instability of active compounds, and challenges related to long-term treatment adherence. Consequently, improving our understanding of how formulation design influences drug penetration, distribution, and local activity within the skin remains a key objective in dermatological and pharmaceutical research.Recent advances in pharmaceutical technology, biomaterials, and formulation science have generated a wide range of innovative delivery systems and topical formulations. These include nanostructured carriers, advanced biomaterial-based systems, and multifunctional formulations designed to interact with the skin barrier in different ways. At the same time, there is increasing recognition of the importance of mechanistic studies that investigate drug permeation, skin–formulation interactions, and the influence of disease-related skin alterations on topical drug delivery.This Research Topic aims to bring together interdisciplinary research exploring innovative formulation and delivery strategies for chronic inflammatory skin diseases and skin aging. Rather than focusing on a single technological approach, the collection seeks to highlight diverse formulation concepts and experimental approaches that contribute to improved understanding of dermal drug delivery. Particular emphasis will be placed on studies that provide mechanistic insights into drug permeation, skin barrier interactions, and the relationship between formulation design and biological performance. Contributions integrating pharmaceutical sciences, dermatology, biomaterials, and skin biology are strongly encouraged.The Research Topic also welcomes work addressing emerging therapeutic concepts, including the delivery of natural bioactive compounds, biocompatible materials, and multifunctional formulations with potential anti-inflammatory, antioxidant, or regenerative effects. Studies employing relevant experimental models, translational approaches, or clinically meaningful evaluation strategies are especially encouraged. By integrating fundamental and applied research, this collection aims to support the development of improved topical therapeutic strategies and to advance current understanding of dermal drug delivery in inflammatory skin conditions and skin aging.We welcome articles addressing innovative approaches to topical and dermal drug delivery relevant to chronic inflammatory skin diseases and skin aging. Topics of interest include, but are not limited to:· Innovative formulation strategies for topical and dermal drug delivery· Nanostructured and advanced carrier systems (e.g., nanoparticles, liposomes, nanofibers, nano-emulsions, hybrid systems)· Mechanistic studies on skin permeation and skin–formulation interactions· Experimental models and methodologies for investigating dermal drug transport· Delivery of natural bioactive compounds, phytochemicals, and plant-derived actives· Formulation approaches targeting inflammation, oxidative stress, skin regeneration, or aging processes· Strategies aimed at improving local drug availability in the skin· Translational and clinically relevant studies in dermatological drug delivery· Safety, regulatory, and scalability considerations in topical formulation developmentStudies limited to basic physicochemical characterization of formulations or in vitro drug release without evaluation of skin permeation, skin interaction, or biological performance are generally outside the scope of this Research Topic. We particularly encourage interdisciplinary contributions spanning pharmaceutical technology, drug delivery, dermatology, biomaterials, and translational pharmaceutical sciences. Topic editors: Tünde Jurca, Ildikó Dr. Bácskay, Laura Grațiela Vicaș Source: https://www.frontiersin.org/research-topics/78897/delivery-systems-and-formulation-strategies-for-chronic-dermatitis-and-skin-aging