Diet, Gut Microbiota, and Inflammaging in Age-Related Chronic-Degenerative Diseases

The interplay between nutrition, gut microbiota, and age-related chronic-degenerative diseases represents a rapidly evolving area within nutritional science. Recent research underscores the critical role of the intestinal microbiome in regulating inflammation, immune responses, and metabolic pathways linked to aging. While traditional studies have primarily focused on metabolic disorders like obesity and diabetes, there is growing interest in exploring how microbiota-driven processes contribute to other prevalent chronic-degenerative diseases associated with aging, including hyperuricemia, gout, sarcopenia, and osteoarthritis. Emerging evidence highlights how dietary patterns and specific nutrients can shape microbial communities and, in turn, affect inflammation and tissue degeneration. However, the precise mechanisms connecting diet, microbial metabolites, and the development or progression of these conditions remain insufficiently understood.This Research Topic aims to clarify the multifaceted relationships between diet, gut microbiota, and the chronic low-grade inflammation commonly seen with aging, known as “inflammaging.” Specifically, it seeks to elucidate how different dietary interventions modulate the gut microbiome, how these changes translate into metabolite profiles, and how such profiles influence immune and metabolic dysfunction in hyperuricemia, gout, sarcopenia, and osteoarthritis. Critical questions include which dietary strategies most effectively promote a beneficial microbiota, how gut-derived metabolites influence inflammatory pathways, and whether targeted nutritional interventions can mitigate or prevent the progression of these chronic conditions.The scope of this Research Topic is confined to human nutrition and its impact on the gut microbiome and inflammation in the context of age-related chronic-degenerative diseases, excluding studies focused on animal models, plant science, or non-nutrition-centric approaches. To gather further insights in these boundaries, we welcome articles addressing, but not limited to, the following themes:o Dietary patterns and their effect on gut microbiota composition in older adultso Microbiota-derived metabolites and their roles in inflammaging and tissue degenerationo Nutritional interventions for the prevention and management of hyperuricemia, gout, sarcopenia, and osteoarthritiso Interactions between diet, microbiota, and immune function in aging populationso Biomarkers linking dietary exposure, gut microbes, and clinical outcomes in chronic-degenerative diseaseso Precision nutrition and personalized dietary approaches targeting microbiota in the context of agingWe encourage the submission of original research articles, clinical trials, systematic or narrative reviews, mini-reviews, case studies or case series, perspectives, and opinion pieces that are relevant to the themes outlined above. Topic editors: Laura Edith Martínez-Gómez, Gabriela Angélica Martínez-Nava, Ivonne Ramírez-Silva, Jorge Maldonado-Hernández, Ana Isabel Burguete Source: https://www.frontiersin.org/research-topics/80478/diet-gut-microbiota-and-inflammaging-in-age-related-chronic-degenerative-diseases