Diet, Nutritional Biomarkers and Functional Outcomes in the Management of Hematologic Malignancies

Malnutrition, cachexia and sarcopenia are common in patients with hematologic malignancies and are strongly associated with poor tolerance of treatment, delayed recovery and reduced survival. Increasing evidence indicates that nutritional status influences immune competence, inflammatory signaling and metabolic homeostasis, all of which affect the outcome of intensive treatments such as chemotherapy, hematopoietic stem cell transplantation and chimeric antigen receptor T cell therapy. Nutritional deficits are particularly pronounced during the peritransplant period and during immune reconstitution, when patients face prolonged catabolic stress, mucositis and reduced oral intake. Despite this evidence, nutrition in hematology has traditionally received less attention than in solid tumor oncology, leaving considerable room for translational and clinical research.This Research Topic aims to advance the understanding of how nutritional status, dietary interventions and specific nutrients influence treatment tolerance, immune recovery and long term outcomes in patients with hematologic malignancies. Recent advances in metabolomics, microbiome analysis and nutrigenomics offer new opportunities to identify biomarkers capable of predicting nutritional risk and stratifying patients before intensive treatments. At the same time, growing interest in immunonutrition and prehabilitation raises the question of whether structured nutritional protocols can improve engraftment, reduce infectious complications and support functional recovery after stem cell transplantation or cellular therapies. We aim to bring together mechanistic, translational and clinical evidence to clarify which nutritional strategies are most effective, for which patients and at which stage of treatment, moving toward more personalized supportive care in hematology.We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to.• Nutritional status, biomarkers and functional outcomes before and after hematopoietic stem cell transplantation• Cancer cachexia and sarcopenia in hematologic malignancies, mechanisms and management• Nutritional support and immunonutrition during chimeric antigen receptor T cell therapy and immune reconstitution• Diet, gut microbiota and inflammation in response to treatment for hematologic malignancies• Precision nutrition, metabolomics and multi omics biomarkers for patient stratification in hematologyPlease note. manuscripts consisting solely of bioinformatics or computational analysis of sole public databases which are not accompanied by validation, either an independent cohort or biological validation in vitro or in vivo, are out of scope for this section and will not be accepted as part of this Research Topic. Topic editors: Pasquale Perrone, Rita Polito Source: https://www.frontiersin.org/research-topics/85445/diet-nutritional-biomarkers-and-functional-outcomes-in-the-management-of-hematologic-malignancies