Dietary Antioxidants and Food-derived Bioactives in Adipogenesis and Anti-obesity Mechanisms

Obesity remains a global public health challenge, with escalating prevalence linked to metabolic dysfunction, chronic inflammation, and increased risk of cardiovascular disease, type 2 diabetes, and certain cancers. While lifestyle modification and pharmaceutical interventions are cornerstone therapies, growing evidence suggests that dietary bioactive compounds—including polyphenols, carotenoids, and other plant-derived antioxidants—may modulate key pathways involved in adipose tissue development and metabolic homeostasis.Recent studies demonstrate that food-derived bioactives can regulate adipogenesis (fat cell differentiation), enhance lipid metabolism, promote browning of white adipose tissue, and suppress pro-inflammatory signaling pathways. However, the molecular mechanisms underlying these effects, bioavailability challenges, and translational potential remain incompletely understood. A comprehensive examination of these mechanisms is essential to develop evidence-based dietary and nutraceutical strategies for obesity prevention and management.Scope & Key TopicsThis Research Topic welcomes original research, systematic reviews, and perspective articles covering:o Molecular and cellular mechanisms of food-derived bioactives in regulating adipogenesis and adipocyte functiono Anti-inflammatory and antioxidant pathways in adipose tissue and their metabolic consequenceso Effects of dietary polyphenols, carotenoids, flavonoids, and other bioactives on white and brown adipose tissueo Bioavailability, metabolism, and tissue-specific accumulation of dietary antioxidantso Pre-clinical and clinical studies investigating dietary interventions for obesity and metabolic dysfunctiono Gut microbiota-mediated mechanisms linking dietary bioactives to metabolic healtho Synergistic effects of multiple bioactive compounds and whole food matriceso Emerging technologies (omics, computational modeling) advancing bioactive-obesity researchTopic Editor Dr. Akiko Kojima-Yuasa received joint research funding annually rom FORDAYS Co., Ltd. in Japan. The other Topic Editors declare no competing interests with regard to the Research Topic subject Topic editors: Akiko Kojima-Yuasa, Toshio Norikura, Isao Matsui-Yuasa Source: https://www.frontiersin.org/research-topics/82763/dietary-antioxidants-and-food-derived-bioactives-in-adipogenesis-and-anti-obesity-mechanisms