Drug Metabolism and Transport: The Frontier of Personalized Medicine, Volume III

This Research Topic is the third edition of the series, previous editions can be found here; Volume I and Volume II : https://www.frontiersin.org/research-topics/44712/drug-metabolism-and-transport-the-frontier-of-personalized-medicine.There are many unique challenges in personalizing drug therapy. Research on pharmacokinetics and pharmacodynamics of drugs is beneficial to ensure the safety and efficacy of clinical medication. There have been many advances in technology and drug model metrology in drug metabolism and transport studies, but our understanding of the factors that influence drug disposition and efficacy still needs to be refined.The purpose of this special issue is to report on factors influencing the pharmacokinetics of drugs, such as drug dosage forms, drug-drug interactions, metabolic enzymes, transporters, pharmacogenetic polymorphisms, pharmacomicrobiome, and specific environments, etc. It aims to standardize personalized medicine and promote clinical rational drug use.This Research Topic will include but is not limited, to reporting:&#8226 Effects of dosage form, dose, and route of administration on pharmacokinetics.&#8226 Pharmacokinetic alterations and mechanisms mediated by drug-drug interactions.&#8226 Mechanism of drug-metabolizing enzyme alterations mediated by external factors, such as high-altitude hypoxia.&#8226 Mechanism of drug transporter changes or gut microbiota mediated by external factors, such as high-altitude hypoxia or antibiotic.&#8226 Effects of gene polymorphisms of drug-metabolizing enzymes on drug action.&#8226 Research methods of intestinal drug transporters.&#8226 Effect of intestinal flora on drug metabolism.&#8226 Discovery of specific probes for drug-metabolizing enzymes.&#8226 Implications of drug interactions mediated by transporters or metabolizing enzymes for precision medicine.&#8226 The utilization of artificial intelligence (AI) and deep learning (DL) in drug metabolism and transport research Topic editors: Junmei Wang, Junmin Zhang, Rong Wang Source: https://www.frontiersin.org/research-topics/73876/drug-metabolism-and-transport-the-frontier-of-personalized-medicine-volume-iii