Electrospinning, 3D Printing, and Advanced Fabrication Technologies for Biomedical Scaffolds and Tissue Constructs

Biofabrication has become a cornerstone of modern biomedical engineering, transforming how functional units—cells, biomaterials, and bioactive molecules—are assembled into three-dimensional constructs that mimic the architecture and function of native tissues. Among the available strategies, Electrospinning, 3D Printing, and Advanced Fabrication stand out for their ability to produce custom, patient-specific structures with controllable geometry, porosity, and mechanical properties. Recent progress in melt electrowriting, near-field electrospinning, multi-material printing, and 4D (shape-memory) fabrication has expanded the design space dramatically, yielding scaffolds with tailored surfaces, hierarchical organization, and responsive behavior. Equally, the controlled release of therapeutic agents—drugs, growth factors, and biologics—from fabricated constructs has opened new avenues for combining structural support with localized, sustained delivery at the site of tissue repair. As these fabrication technologies mature, the field’s key remaining bottlenecks are shifting toward integration, reproducibility, scalable manufacturing, and clinical translation — limited material libraries, reproducibility and standardized characterization, scalable manufacturing, integration of living cells, and the translation of laboratory constructs into validated clinical and industrial products.This Research Topic aims to connect the latest advances in fabrication strategy with their application in tissue engineering, regenerative medicine, drug delivery, and biomedical devices. We seek multidisciplinary contributions that draw on engineering, materials science, chemistry, and life sciences to design, fabricate, characterize, and validate functional constructs. Given that biofabrication and advanced manufacturing methods are now relatively well established, we particularly encourage contributions that integrate existing technologies into robust, standardized, and scalable workflows supporting clinical translation and medical device development — alongside work that improves control over scaffold architecture and material properties, integrates controlled release functionality, bridges fabrication with biological performance, and addresses the reproducibility and translational hurdles that currently limit real-world deployment.This Research Topic will encompass original research and reviews focusing on fabrication technologies and their role in biomedical construct development. The scope will not include studies on non-biomedical applications of these technologies, in accordance with the section’s guidelines. To gather further insights, we welcome articles addressing, but not limited to, the following themes:- Advanced and scalable methods for Electrospinning, 3D Printing, and Advanced Fabrication of biomedical constructs- Bio(material) ink and biopolymer development, characterization, and processing- Design and fabrication of scaffolds for tissue engineering and regenerative medicine- Fabricated constructs for controlled and localized delivery of drugs, growth factors, and biologics- Characterization and imaging of construct architecture and scaffold–cell interfaces- Smart and responsive (4D-printed) materials for biomedical devices- Novel hardware, instrumentation, and process modeling for biofabrication, and in vitro/in vivo validation, reproducibility, and translational considerations for clinical and industrial deployment Topic editors: Andrea Ehrmann, Lilia Sabantina, Nonsikelelo Sheron Mpofu Source: https://www.frontiersin.org/research-topics/83977/electrospinning-3d-printing-and-advanced-fabrication-technologies-for-biomedical-scaffolds-and-tissue-constructs