Elucidating Molecular Mechanisms Responsible for Spinal Cord Injury (Sci)-induced Brain Neuroinflammation and Neurodegeneration

Spinal cord injury (SCI) has long been considered a localized condition, yet mounting evidence suggests that it exerts widespread effects on the central nervous system, including the brain. In particular, SCI has been shown to induce persistent neuroinflammation and neurodegenerative changes in brain regions involved in cognition, emotion, and sensorimotor processing. These secondary brain pathologies may underlie many of the long-term neurological and psychological complications observed in SCI patients.This Research Topic aims to bring together cutting-edge studies that explore the molecular and cellular mechanisms linking SCI to brain neuroinflammation and neurodegeneration. We welcome contributions employing diverse approaches including transcriptomic and proteomic profiling, single-cell and spatial analyses, in vivo and in vitro models, as well as neuroimaging and neuropathological studies in clinical populations.Topics of interest include, but are not limited to:• Crosstalk between the injured spinal cord and the brain: signaling pathways and immune mediators• Microglial and astrocyte activation in supraspinal regions post-SCI• Blood-brain barrier dysfunction following SCI• Neuroimmune axis dysregulation and systemic inflammation• Long-term effects of SCI on synaptic plasticity and neuronal survival in the brain• Therapeutic strategies targeting secondary brain inflammation and degeneration in SCIThrough this Research Topic, we aim to deepen the understanding of SCI as a whole-brain disorder and foster interdisciplinary insights that may lead to novel interventions to mitigate chronic complications in SCI survivors. Topic editors: Wu Zhou, Antje Kroner, Li Meihua Source: https://www.frontiersin.org/research-topics/73695/elucidating-molecular-mechanisms-responsible-for-spinal-cord-injury-sci-induced-brain-neuroinflammation-and-neurodegeneration