Endocrinology, Reproduction and Endometriosis

Endometriosis research has evolved substantially in recent years, shedding light on its complex role in female reproductive health, particularly regarding infertility. Endometriosis is characterized by the ectopic presence of endometrial-like tissue, leading to chronic inflammation, pelvic pain, and reduced fertility among women of reproductive age. Epidemiological studies, including those in Indian populations, have identified a considerable prevalence of this disorder and emphasized its significant reproductive implications. While older models primarily linked infertility in endometriosis to anatomical distortions such as pelvic adhesions and fibrosis, recent evidence suggests a more intricate etiology, highlighting the interplay between inflammatory, endocrine, genetic, and epigenetic mechanisms. Despite advancements, the precise contributions of these pathways to reproductive dysfunction are still not fully delineated.Currently, growing attention is being paid to the genetic and endocrine components underlying endometriosis-associated infertility. Genome-wide association studies have identified several susceptibility genes, indicating heritable risk factors that may impact disease presence and fertility outcomes. Likewise, hormonal imbalances, increasingly recognized in both endometriosis and related disorders such as polycystic ovary syndrome (PCOS), further complicate the reproductive landscape. Population-based research has underscored significant endocrine variability, supporting the need for population-specific reference data. However, the heterogeneity in reproductive outcomes among women with endometriosis suggests that multifaceted molecular interactions—rather than single-factor explanations—are at play, justifying integrative investigations of both genetic and hormonal axes.This Research Topic aims to advance understanding of the molecular determinants of infertility in endometriosis by examining the intersecting roles of genetic susceptibility and endocrine dysregulation. Specifically, it seeks to identify genetic and epigenetic factors that modulate endometrial receptivity and reproductive success, evaluate the impact of hormonal profiles on fertility potential, and explore gene-endocrine interactions that may influence disease severity and outcomes. By addressing these multidimensional aspects, the Research Topic strives to inform risk stratification, support personalized medicine approaches, and ultimately improve clinical management and reproductive prognosis for affected women.The scope of this Research Topic encompasses the integrated study of genetic, epigenetic, and endocrine contributions to infertility in women with endometriosis, with particular emphasis on population-relevant findings and translational implications. Studies focusing exclusively on clinical interventions or anatomical factors without exploring molecular etiology may fall outside the primary intent. To gather further insights into these complex interactions, we welcome articles addressing, but not limited to, the following themes:- Genetic association studies and susceptibility loci in endometriosis-related infertility- Epigenetic modifications influencing endometrial receptivity and implantation- Endocrine profiling and hormonal parameters affecting reproductive outcomes- Molecular crosstalk between inflammation, genetics, and endocrine factors- Population-based reference ranges and implications for precision medicine in infertility- Clinical and translational approaches to risk stratification based on genetic and endocrine biomarkers Topic editors: Roya Rozati, Radhey Shyam Sharma, Aleem Ahmed Khan, Dr Chinthamadaka Sairam Source: https://www.frontiersin.org/research-topics/79548/endocrinology-reproduction-and-endometriosis