Engineering nanostructured antibacterials: Bioinspired surfaces and the future of mechano-bactericidal nanobiotechnology

Nanobiotechnology, situated at the dynamic interface between nanotechnology and life sciences, is revolutionizing approaches to biomedical challenges by manipulating biological systems at the nanoscale. One of the most pressing threats in medicine today—antimicrobial resistance (AMR)—demands new strategies beyond conventional antibiotics. Recent breakthroughs have shown that bioinspired nanostructured surfaces, modeled after naturally bactericidal systems such as cicada or dragonfly wings, can physically disrupt bacterial cells without relying on chemical agents. These nanoscale biomaterials offer promising routes for functional nanostructured surfaces that actively suppress bacterial colonization and biofilm development, with profound implications for regenerative medicine, medical device safety, and broad-spectrum antimicrobial strategies.This Research Topic aims to advance the understanding and application of bioinspired mechano-bactericidal nanostructured surfaces within the framework of nanobiotechnology. By exploring the controlled synthesis, precise characterization, and functional optimization of these surfaces, the collection seeks to uncover the design rules that govern their antimicrobial properties. The goal is to attract multidisciplinary research that not only elucidates the mechanistic bases of bacterial membrane penetration and rupture but also translates these discoveries into new biomedical platforms—such as nano-engineered implants, wound dressings, and diagnostic devices—aligned with Sustainable Development Goals in health and innovation.To gather further insights in this rapidly evolving field, the scope of this Research Topic includes innovative research and in-depth reviews focused on the development, engineering, and translational potential of mechano-bactericidal nanostructured surfaces. Only studies engaged with nanoscale biomaterial design, device integration, and molecular-level interactions will be considered, ensuring alignment with the core mission of the Nanobiotechnology section. We welcome articles addressing, but not limited to, the following themes:- Fabrication and advanced characterization of functional nanostructured and bioinspired surfaces- Structure–function relationships and quantitative analysis of bactericidal mechanisms- Synthesis and modification of nanoscale biomaterials for infection-resistant medical devices- Applications in organ-on-chip technologies, regenerative medicine, or nanobiosensing- Assessment of biocompatibility, nanotoxicology, and durability- Translational and regulatory perspectives in deploying nano-enabled antibacterials Topic editors: Neetu Talreja, Mohammad Ashfaq, Richard Bright Source: https://www.frontiersin.org/research-topics/78301/engineering-nanostructured-antibacterials-bioinspired-surfaces-and-the-future-of-mechano-bactericidal-nanobiotechnology