Enterohepatic Circulation in Gastrointestinal and Liver Diseases: Advances from Mechanistic Insights to Clinical Practice

Nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), has become one of the most prevalent chronic liver diseases worldwide. The gut–liver axis represents a critical bidirectional communication network linking intestinal homeostasis, microbial composition, and hepatic metabolic and immune function. Emerging evidence highlights that alterations in intestinal permeability, microbial dysbiosis, and bile acid metabolism play pivotal roles in the onset and progression of fatty liver disease.Disruption of the intestinal barrier leads to translocation of bacterial endotoxins and metabolites into the portal circulation, triggering hepatic inflammation, lipid accumulation, and fibrosis. Meanwhile, hepatic injury may in turn modulate gut microbiota and intestinal integrity through bile acid signaling and immune regulation, forming a vicious cycle that promotes disease progression. Understanding the complex interplay among gut microbiota, intestinal barrier, and hepatic metabolism is essential for identifying new diagnostic biomarkers and therapeutic strategies.This Research Topic aims to gather cutting-edge research exploring the pathophysiological mechanisms, experimental models, and clinical implications of the gut–liver axis in fatty liver disease. We welcome submissions that address, but are not limited to, the following areas:1. Role of gut microbiota and microbial metabolites in hepatic steatosis, inflammation, and fibrosis2. Mechanisms regulating intestinal barrier integrity and permeability in metabolic liver disease3. Crosstalk between bile acids, short-chain fatty acids, and liver immune or metabolic pathways4. Translational and clinical studies evaluating microbiota-targeted interventions (e.g., probiotics, prebiotics, antibiotics, or fecal microbiota transplantation)5. Novel diagnostic biomarkers and therapeutic targets derived from the gut–liver axis.By integrating evidence from basic, translational, and clinical research, this collection seeks to deepen our understanding of how the gut–liver axis contributes to fatty liver pathogenesis and to identify innovative therapeutic strategies that could transform clinical practice. Topic editors: Chenyu Sun Source: https://www.frontiersin.org/research-topics/75988/enterohepatic-circulation-in-gastrointestinal-and-liver-diseases-advances-from-mechanistic-insights-to-clinical-practice